Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review

Wang, Dong; Wan, Xin

doi:10.1016/j.biopha.2022.113923

Cited by 7 publications

(4 citation statements)

References 165 publications

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“…The metabolic reprogramming strategy affects the metabolism of tumor cells and the metabolic behavior of immune cells. [102,232] Not only does it affect the antigen presentation and recognition of immune cells, but also the metabolic processes will affect their immune functions. To bring into full play the therapeutic potential of tumor metabolic reprogramming, on the one hand, we must strive to comprehend sufficiently the metabolic mechanism of tumor immune evasion and the metabolic needs of immune cells.…”

Section: Discussionmentioning

confidence: 99%

“…[99] The "Warburg effect" is currently the most concerned model of cellular metabolic remodeling, which plays an essential role in rapid cancer occurrence and development. [102,103] In addition to the unique, abnormal aerobic glycolysis, tumor cells also use other metabolic pathways, such as mitochondrial oxidative phosphorylation (OX-PHOS), amino acid metabolism, and lipid metabolism, which are crucial for cancer cells to obtain energy and nutrients. [104] Recently, metabolic drugs have been utilized as therapeutic adjuvants to improve the tumor microenvironment through metabolic reprogramming, providing optimized solutions for enhancing PDT efficacy.…”

Section: Intervention Of Tumor Cell Metabolismmentioning

confidence: 99%

“…Otto Warburg observed for the first time in 1924 that cancer cells tend to undergo intense oxygen-consuming glycolysis and produce lactic acid even in the case of sufficient oxygen, a phenomenon known as the "Warburg effect"/"aerobic glycolysis." [32,102,108,112,113] Aerobic glycolysis is a critical link in the occurrence and development of cancer. [114] High-throughput glycolysis can fast supply energy for cancer cells and produce a variety of critical intermediate metabolites, laying a foundation Intervention in Aerobic Glycolysis (Glucose and Lactic Acid)…”

Section: Intervention In Aerobic Glycolysismentioning

confidence: 99%

“…Glutamine (Gln) is an essential nutrient in tumor cells, second only to glucose, and is closely correlated to the progression of many cancers. [102,124] Glutamine is a carbon source for the synthesis of lipids and metabolites via the citric acid (CTA) cycle, as well as a nitrogen source for the synthesis of amino acids and nucleotides. [113,125,126] Therefore, Gln addiction is one of the most crucial amino acid metabolic abnormalities in cancer cells, manifested by the specific uptake of glutamine by tumor cells, which is used to generate energy and as carbon and nitrogen sources for biosynthesis.…”

Section: Intervention In Glutamine Metabolismmentioning

confidence: 99%

See 3 more Smart Citations

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Yu,

Li,

Wang

et al. 2023

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Photodynamic therapy (PDT) has recently been considered a potential tumor therapy due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill tumor cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response by causing immunogenic cell death of tumor cells. Although it exhibits a promising prospect in treating tumors, there are still many problems to be solved in its practical application. Tumor hypoxia and immunosuppressive microenvironment seriously affect the efficacy of PDT. The hypoxic and immunosuppressive microenvironment is mainly due to the abnormal vascular matrix around the tumor, its abnormal metabolism, and the influence of various immunosuppressive‐related cells and their expressed molecules. Thus, reprogramming the tumor microenvironment (TME) is of great significance for rejuvenating PDT. This article reviews the latest strategies for rejuvenating PDT, from regulating tumor vascular matrix, interfering with tumor cell metabolism, and reprogramming immunosuppressive related cells and factors to reverse tumor hypoxia and immunosuppressive microenvironment. These strategies provide valuable information for a better understanding of the significance of TME in PDT and also guide the development of the next‐generation multifunctional nanoplatforms for PDT.

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Section: Discussionmentioning

confidence: 99%

Section: Intervention Of Tumor Cell Metabolismmentioning

confidence: 99%

Section: Intervention In Aerobic Glycolysismentioning

confidence: 99%

Section: Intervention In Glutamine Metabolismmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Yu,

Li,

Wang

et al. 2023

Small

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The Influence of the Amino Acid Transporter LAT1 on Patient Prognosis and the Relationships between Tumor Immunometabolic and Proliferative Features Depend on Menopausal Status in Breast Cancer

Ramshankar,

Liu,

Perry

2023

Preprint

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L-type Amino Acid Transporter 1 (LAT1) facilitates the uptake of specific essential amino acids, and due to this quality, it has been correlated to worse patient outcomes in various cancer types. However, the relationship between LAT1 and various clinical factors, including menopausal status, in mediating LAT1's prognostic effects remains incompletely understood. This is particularly true in the unique subset of tumors that are both obesity-associated and responsive to immunotherapy, including breast cancer. To close this gap, we employed 6 sets of transcriptomic data using the Kaplan-Meier model in the Xena Functional Genomics Explorer, demonstrating that higher LAT1 expression diminishes breast cancer patients' survival probability. Additionally, we analyzed 3'-Deoxy-3'-18F-Fluorothymidine positron emission tomography-computed tomography (18F-FLT PET-CT) images found on The Cancer Imaging Archive (TCIA). After separating all patients based on menopausal status, we correlated the measured 18F-FLT uptake with various clinical parameters quantifying body composition, tumor proliferation, and immune cell infiltration. By analyzing a wealth of deidentified, open-access data, the current study investigates the impact of LAT1 expression on breast cancer prognosis, along with the menopausal status-dependent associations between tumor proliferation, immunometabolism, and systemic metabolism.

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The Mechanism Study of Single Nucleotide Polymorphism rs3094165 Regulating the Progression of Hepatocellular Carcinoma via Modulating NADH Dehydrogenase Ubiquinone Fe–S Protein-1

Sun,

Cui,

et al. 2023

j biomater tissue eng

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Hepatocellular carcinoma (HCC) is a major contributor to global cancer-related mortality, under-scoring the urgent need to identify effective prognostic markers. Single nucleotide polymorphisms (SNPs) play an increasingly important role in predicting the prognosis of patients with HCC. In this study, a cohort of 637 HCC patients was enrolled, and various online databases were comprehensively surveyed to identify SNPs that potentially impact HCC patient survival. The results of the Cox regression analysis demonstrated a significant association between rs3094165 and poor prognosis among patients with HCC. Further PSM analysis was also employed to control potential biases, and the results remained consistent. These findings suggest that SNPs can serve as reliable prognostic markers for HCC patients. Then, we conducted functional experiments to explore the molecular mechanism and confirmed that rs3094165 potentially regulates the progression of HCC by modulating the expression of the NDUFS1. Taken together, our study provides a comprehensive analysis of SNPs associated with HCC prognosis, and highlights the importance of rs3094165 as potential biomarkers for predicting poor prognosis of HCC patients. Our findings also shed light on the influence of rs3094165 on HCC progression by regulating NDUFS1 expression.

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Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review

Cited by 7 publications

References 165 publications

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

The Influence of the Amino Acid Transporter LAT1 on Patient Prognosis and the Relationships between Tumor Immunometabolic and Proliferative Features Depend on Menopausal Status in Breast Cancer

The Mechanism Study of Single Nucleotide Polymorphism rs3094165 Regulating the Progression of Hepatocellular Carcinoma via Modulating NADH Dehydrogenase Ubiquinone Fe–S Protein-1

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