Progress in Research on the Role of Flavonoids in Lung Cancer

Abstract

Lung cancer is the leading cause of cancer deaths worldwide. Therefore, for the prevention, diagnosis, prognosis and treatment of lung cancer, efficient preventive strategies and new therapeutic strategies are needed to face these challenges. Natural bioactive compounds and particular flavonoids compounds have been proven to have an important role in lung cancer prevention and of particular interest is the dose used for these studies, to underline the molecular effects and mechanisms at a physiological concentration. The purpose of this review was to summarize the current state of knowledge regarding relevant molecular mechanisms involved in the pharmacological effects, with a special focus on the anti-cancer role, by regulating the coding and non-coding genes. Furthermore, this review focused on the most commonly altered and most clinically relevant oncogenes and tumor suppressor genes and microRNAs in lung cancer. Particular attention was given to the biological effect in tandem with conventional therapy, emphasizing the role in the regulation of drug resistance related mechanisms.

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

“…By far, the prognosis remains unsatisfactory, despite the availability of traditional treatment options involving surgery, radiation, chemotherapy, and specific targeted therapies, primarily due to late diagnosis and late appearance of metastasis, especially in conditions associated with lung cancer [ 264 , 265 ]. The role of numerous flavonoids in lung cancer have been discussed by Zanoaga et al and Collins et al [ 266 , 267 ], and Qu, identified as having antitumor properties, has been tested for its impact on aurora B activities in a study conducted by Xingyu et al [ 160 ]. Aurora B, a protein part of series of serine–threonine kinase, is important during attachment of mitotic spindle to the cancer cells and centromere; overexpression of aurora B causes uneven division of genetic information, generating aneuploidy in cells, a characteristic of cancer [ 268 ].…”

Demethylation of <em>HACE1</em> gene promoter by propofol promotes autophagy of human A549&nbsp;cells

“…The 5-year survival rate of patients with lung cancer is <17% ( 6 ). Different anticancer strategies have been developed and used in clinical treatment of lung cancer, including surgery, chemotherapy, immunotherapy and targeted therapy ( 10 – 13 ). However, these strategies do not effectively improve the long-term survival rate of patients with lung cancer, so novel effective therapeutic interventions and targets are urgently needed.…”

Astragaloside IV Enhances Melanogenesis via the AhR‐Dependent AKT/GSK‐3β/β‐Catenin Pathway in Normal Human Epidermal Melanocytes

“…Many natural products can regulate melanogenesis through AhR activation [ 23 ]. AS-IV is a kind of natural flavonoids [ 24 – 26 ] which have been identified as exogenous ligands of AhR [ 27 ]. Currently, our study showed that AS-IV could stimulate the melanin synthesis via activating AhR in NHEMs.…”