Progress in research on gold nanoparticles in cancer management

Abstract

Introduction: The rapid advancement of nanotechnology in recent years has fuelled burgeoning interest in the field of nanoparticle research, particularly its application in cancer management. At present, there seems to be heightened interest in the application of gold nanoparticles (AuNPs) to the management of cancer, encompassing diagnosis, monitoring, and treatment. AuNPs could be used as drug delivery agents that target cancer cells or in gene therapy. These efforts are undertaken in the hope of revolutionizing current methods and strategies for cancer treatment. This review will focus on the current applications of AuNPs in cancer management. Objectives, data sources, study appraisal and synthesis methods, results: objectives, data sources, study eligibility criteria, participants, and interventions, study appraisal and synthesis methods, results are not required, as the study will be a literature review. Just introduction, ethics and dissemination, and conclusion are applicable. Ethics and dissemination: Ethical approval and informed consent are not required, as the study is a literature review and does not involve direct contact with patients or alterations to patient care. Conclusion: AuNPs have many properties that are of great value for the diagnosis and treatment of tumors. AuNPs are small in size and can penetrate widely and deposit on the tumor site, bind to many proteins and drugs, target delivery drugs, and have good biocompatibility. The application of AuNPs in the diagnosis and treatment of tumors is very considerable. In the near future, AuNPs will certainly play an important role in the treatment of tumors.

Proteome interrogation using gold nanoprobes to identify targets of arctigenin in fish parasites

“…Gold nanoparticles are arguably the most versatile nanomaterials reported up to now [45]. Due to the biological and chemical properties, their wide applications range from drug delivery to cancer therapy [46][47][48]. In the present study, gold nanoprobes were employed to identify drug targets in parasites for the first time.…”

The Inhibitory Effects of Gold Nanoparticles on VEGF-A-Induced Cell Migration in Choroid-Retina Endothelial Cells

“…AuNPs have been explored with a high expectation as they are effective and promising agents to improve the diagnosis and treatment of cancer [27][28][29]. Gold nanoparticles downregulate cellular cascades of interleukin-1β-induced pro-inflammatory response [30], and topical application of AuNPs decreases intraocular oxidative damage and inflammation [31].…”

Gene Therapy in Cancer Treatment: Why Go Nano?

“…Moreover, they can be easily functionalized with different moieties improving biocompatibility and internalization and their optical properties at the nanoscale makes possible to track their intracellular localization [17,158,159]. In the last years, several different applications of AuNPs as carriers in cancer therapy have been described [17,[160][161][162]. Indeed, AuNPs functionalized with novel drugs/compounds have been described to increase drug efficacy and tumor reduction [49,160,163,164].…”

“…In the last years, several different applications of AuNPs as carriers in cancer therapy have been described [17,[160][161][162]. Indeed, AuNPs functionalized with novel drugs/compounds have been described to increase drug efficacy and tumor reduction [49,160,163,164]. Recently, Coelho et al developed a drug delivery nanosystem based on pegylated AuNPs loaded with doxorubicin and varlitinib, an anthracycline and a tyrosine kinase inhibitor respectively, for a combined approach against pancreatic cancer cells [165].…”

“…That is one of the advantages of binding nucleic acids to AuNPs' surface since, due to steric hindrance the nucleic acid is protected from degradation by nucleases [160]. AuNPs are progressively being used in vitro and in vivo for gene therapy purposes due to their high payload (due to large specific surface area), low toxicity, enhanced uptake, fast endosomal escape, increased half-life; efficient and selective gene silencing [160,167]. For instance, Ryou and collaborators used AuNPs to deliver RNA aptamers, specific to the β-catenin gene, into the nucleus of cancer cells.…”