Progress in PRRSV Infection and Adaptive Immune Response Mechanisms

Cai, Hui; Zhang, Hewei; Cheng, H. N.; Liu, Min; Wen, Sijian; Ren, J. R.

doi:10.3390/v15071442

Cited by 12 publications

(3 citation statements)

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“…ADE in livestock viral infections has been speculated for ASFV, PRRSV, and FMDV ( 206 – 208 ). Most literature surrounding ADE stems from in vitro assays where enhanced levels of viral replication have been detected in the presence of serum antibodies ( 206 ). Although well described for dengue virus ( 209 ), ADE remains controversial for these livestock diseases as the small number of in vivo studies reported have shown limited evidence of ADE occurring ( 206 , 210 ).…”

Section: Humoral Immune Features As Correlates Of Protectionmentioning

confidence: 99%

“…In rare instances, vaccine-induced antibodies may play a role in antibody-dependent enhancement (ADE) of infections where viral immune complexes are phagocytosed by immune cells and lead to a productive infection ( 205 ). ADE in livestock viral infections has been speculated for ASFV, PRRSV, and FMDV ( 206 – 208 ). Most literature surrounding ADE stems from in vitro assays where enhanced levels of viral replication have been detected in the presence of serum antibodies ( 206 ).…”

Section: Humoral Immune Features As Correlates Of Protectionmentioning

confidence: 99%

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Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases

Davis,

Jia,

Wright

et al. 2024

Front. Immunol.

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Enhancing livestock biosecurity is critical to safeguard the livelihoods of farmers, global and local economies, and food security. Vaccination is fundamental to the control and prevention of exotic and endemic high-priority infectious livestock diseases. Successful implementation of vaccination in a biosecurity plan is underpinned by a strong understanding of correlates of protection—those elements of the immune response that can reliably predict the level of protection from viral challenge. While correlates of protection have been successfully characterized for many human viral vaccines, for many high-priority livestock viral diseases, including African swine fever and foot and mouth disease, they remain largely uncharacterized. Current literature provides insights into potential correlates of protection that should be assessed during vaccine development for these high-priority mammalian livestock viral diseases. Establishment of correlates of protection for biosecurity purposes enables immune surveillance, rationale for vaccine development, and successful implementation of livestock vaccines as part of a biosecurity strategy.

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Section: Humoral Immune Features As Correlates Of Protectionmentioning

confidence: 99%

Section: Humoral Immune Features As Correlates Of Protectionmentioning

confidence: 99%

Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases

Davis,

Jia,

Wright

et al. 2024

Front. Immunol.

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“…PRRSV is a member of the Arteriviridae family of enveloped viruses (Ma et al, 2021;Ruedas-Torres et al, 2021). The viral genome is a single-stranded positive-sense RNA and a great deal of new information has been gained on the pathogenicity of the viral infection that is now known to include deficits in the infected pig innate immune system (Cai et al, 2023). While there exists a commercial vaccine against PRRSV, it offers only modest protection for pigs due in part to the problem of preparing an effective vaccine against all known virus variants (Du et al, 2017;Ma et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of oleandrin and PBI-05204 against viruses of importance to commercial pig health management

Newman,

Abdelsalam,

Buterbaugh

et al. 2024

Front. Anim. Sci.

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BackgroundInfection by porcine respiratory and reproductive syncytial virus (PRRSV), swine influenza virus (SIV) and porcine epidemic diarrhea (PEDV) adversely affect worldwide pig production. Because effective control remains elusive the present research was designed to explore the in vitro antiviral activity of oleandrin and an N. oleander extract (PBI-05204) against each porcine virus.MethodsMonkey kidney (MARK-145) cells, Madin-Darby canine kidney cells (MDCK), and African green monkey kidney cells (VERO 76) were used for in vitro culture systems for PRRSV, SIV and PEDV, respectively. Cytotoxicity was established using serial dilutions of oleandrin or PBI-05204. Noncytotoxic concentrations of each product were used either prior to or at 12 h and 24 h following exposure to corresponding viruses. Infectious virus titers were also determined.ResultsOleandrin and PBI-05204 demonstrated strong antiviral activity against PRRSV, SIV and PEDV when added prior to or following infection of cells. Determination of viral loads by PCR demonstrated a decline in PRRSV replication reaching 99.57% and 99.79% for oleandrin and PBI-05204, respectively, and decrease of 95.36% and 99.54% in infectivity of progeny virus in PRRSV infected cultures. Similarly, oleandrin tested against SIV and PEDV was effective in near complete inhibition of infectious virus production.ConclusionThe research demonstrates the potency of oleandrin and PBI-05204 to inhibit infectivity of three important porcine viruses. These data showing non-toxic concentrations of oleandrin as a single common agent for inhibiting infectivity of the three different porcine viruses tested here support further investigation of antiviral efficacy and possible in vivo use.

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Development of an enzyme-linked immunosorbent assay using a monoclonal antibody to a dominant epitope in non-structural protein 4 of porcine reproductive and respiratory syndrome virus

Fu,

Shao,

Zhang

et al. 2024

Journal of Immunological Methods

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Progress in PRRSV Infection and Adaptive Immune Response Mechanisms

Cited by 12 publications

References 100 publications

Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases

Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases

Efficacy of oleandrin and PBI-05204 against viruses of importance to commercial pig health management

Development of an enzyme-linked immunosorbent assay using a monoclonal antibody to a dominant epitope in non-structural protein 4 of porcine reproductive and respiratory syndrome virus

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