Progress in progestin-based therapies for neurological disorders

Sitruk-Ware, Régine; Bonsack, Brooke; Brinton, Roberta Dı́az; Schumacher, Michaël; Kumar, Narender; Lee, Jea-Young; Castelli, Vanessa; Corey, Sydney; Coats, Alexandreya B.; Sadanandan, Nadia; Gonzales-Portillo, Bella; Heyck, Matt; Shear, Alex; Cozene, Blaise; Zhang, Henry; Sheyner, Michael; García–Sánchez, J.; Navarro, Lisset; El‐Etr, Martine; Nicola, Alejandro De; Borlongan, Cesario V.

doi:10.1016/j.neubiorev.2020.12.007

Cited by 23 publications

(26 citation statements)

References 283 publications

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“…Multiple sclerosis, amyotrophic lateral sclerosis, spinal cord injury and stroke are diseases that develop via demyelinating, cell death, and/or inflammatory pathological pathways, and progestins have meaningful roles in these processes. The detailed mechanisms are reviewed in Sitruk-Ware et al (2021) [ 218 ], and here we provide only a short overview of the role of PROG in treating CNS disorders.…”

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

“…Taken together, there is evidence that PROG is an important regulator of myelination during development and myelin repair after pathology in the CNS [ 230 ], and that it strongly influences the myelin synthesis in the peripheral and central nervous system [ 231 , 232 , 233 ]. The exact mechanism by which PROG promotes myelin formation is not yet fully understood; however, the participation of PRs is evident [ 218 , 228 ]. It is also worth noting that there is a shift towards anti-inflammatory cytokine synthesis in the presence of PROG.…”

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

“…The high number of experimental studies documenting neuroprotective and remyelination functions makes PROG seem to be a promising therapeutic option for multiple sclerosis [ 218 , 235 ]. Positive aspects of such treatment include the many active metabolites, long-term experience with their use, and its safety with few negative side effects.…”

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

“…One major disadvantage of natural PROG usage is the first-pass liver effect, which degrades a high percentage of PROG ingested. The beneficial effects of PROG outweigh these disadvantages, however, and research into the development of natural progesterone analogues is constantly being driven forward [ 218 ].…”

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

“…PROG also protects against glutamate excitotoxicity in vitro, one of the major sources of pathology in amyotrophic lateral sclerosis [ 40 ]. Synthetic 19-norprogesterone derivatives may also play a role in attenuating motoneuron degeneration and thus have potential in amyotrophic lateral sclerosis treatment [ 218 ].…”

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

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Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine

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et al. 2022

IJMS

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Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid have been documented, of which its neuro- and immunoprotective activities are the most widely discussed. Discoveries of the novel biological activities of progesterone have also driven research and development in the field of progesterone analogues used in human medicine. Progestogen treatment has traditionally and predominately been used in maintaining pregnancy, the prevention of preterm labor, various gynecological pathologies, and in lowering the negative effects of menopause. However, there are also various other medical fields where progesterone and its analogues could find application in the future. The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of progesterone and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment.

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Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

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Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine

Kolátorová

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Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy

Meng,

Ren,

Dong

et al. 2023

Adv Funct Materials

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Recently, neurological disorders have led to a growing global burden of fatalities and disabilities. The limited capacity for natural self‐regeneration poses a significant challenge in repairing nervous system injuries, which is closely related to the complex microenvironment and nonregenerative nature of neurons. Metal–organic frameworks (MOFs), with their distinctive structure and properties including high surface area, porosity, tunability, stimuli‐responsive behavior, biocompatibility, and biodegradability, stand as an auspicious platform for devising therapeutic strategies aiming at nerve regeneration and repair. By taking advantage of these characteristics, researchers have the opportunity to explore innovative methods including endogenous stimulation, magnetic response therapy, phototherapy, ultrasound therapy, and drug delivery systems for the treatment of neurological diseases. Moreover, MOFs‐based stem cell therapy also is developed to inhibit neuroinflammation and oxidative stress, promote axon growth, regulate stem cell differentiation, promote nerve regeneration, and finally restore the function of injured nerves. In this paper, the preparation strategy and biological characteristics of MOFs, highlighting their applications in repairing nerve injuries and treating neural stem cells is presented. Finally, an outlook on the future development and challenges in the field of neuroscience concerning MOFs is provided.

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