Progress in osteoarthritis research by the National Natural Science Foundation of China

Li, Yusheng; Xie, Wenqing; Xiao, Wenfeng; Dou, Dou

doi:10.1038/s41413-022-00207-y

Cited by 21 publications

(10 citation statements)

References 94 publications

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“…In general, radiographic OA is more prevalent than symptomatic OA. 11 , 12 The Global Burden of Disease (GBD) study showed that the global OA prevalence was about 300 million in 2017 and rapidly increased to 530 million in 2019. 13 , 14 The prevalence rate of OA has elevated by 9.3% from 1990 to 2017 and by 13.25% from 1990 to 2019.…”

Section: Prevalencementioning

confidence: 99%

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Yao

Tao

et al. 2023

Sig Transduct Target Ther

319

147

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Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues, which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction. Currently, there is no cure for OA, partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease. Therefore, a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development. In this review, we first summarize the epidemiology of OA, including its prevalence, incidence and burdens, and OA risk factors. We then focus on the roles and regulation of the pathological signaling pathways, such as Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/ΒΜP and FGF signaling pathways, and key regulators AMPK, mTOR, and RUNX2 in the onset and development of OA. In addition, the roles of factors associated with OA, including MMPs, ADAMTS/ADAMs, and PRG4, are discussed in detail. Finally, we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA. Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies.

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Section: Prevalencementioning

confidence: 99%

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Yao

Tao

et al. 2023

Sig Transduct Target Ther

319

147

View full text Add to dashboard Cite

show abstract

“…Osteoarthritis (OA) is the most common debilitating disease, a leading cause of disability, and is characterized by chronic pain and whole arthropathies such as articular cartilage damage, synovitis, subchondral bone remodeling and osteophyte formation. 1 – 3 The prevalence of OA is increasing steadily due to the aging population and worldwide obesity epidemic, which brings a great social burden and imposes a major challenge on public health. 4 – 6 It is estimated that 303 million adults in the world were affected, and in China, approximately 61.2 million people had OA in 2017.…”

Section: Introductionmentioning

confidence: 99%

Current understanding of osteoarthritis pathogenesis and relevant new approaches

et al. 2022

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Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key mediators in OA-associated pain. We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain, such as CRISPR, scRNA sequencing, and lineage tracing. Next, we discuss the timely updates concerning cell death regulation in OA pathology, including pyroptosis, ferroptosis, and autophagy, as well as their individual roles in OA and potential molecular targets in treating OA. Finally, our review highlights new directions on the role of the synovial lymphatic system in OA. An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.

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“…OA has a complex disease process associated with synovium, articular cartilage, subchondral bone, ligament, joint capsule and muscles around joints ( Huang et al, 2022 ). With the accelerating of population aging, the population suffering from OA has reached 200 million, which results in huge living obstacles and heavy economic burden to the society ( Li Y. et al, 2022 ; Zhao et al, 2022 ). Over the past decades, intra-articular injection of various stem cells has emerged as an advanced therapy to delay the pathological progress of OA.…”

Section: Introductionmentioning

confidence: 99%

Naturally derived injectable hydrogels with ROS-scavenging property to protect transplanted stem cell bioactivity for osteoarthritic cartilage repair

Xiang

Gong

et al. 2023

Front. Bioeng. Biotechnol.

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Intra-articular injection of adipose mesenchymal stem cells (ADSCs) is a potential alternative to the treatment of osteoarthritis (OA) and has aroused great interest of clinical researchers. However, the hostile microenvironment in the joint cavity, characterized by reactive oxygen species (ROS) accumulation and excessive inflammation, disturbs the bioactivity of the transplanted stem cells. The (-)-epigallocatechin-3-O-gallate (EGCG), a green tea catechin, has attracted the researchers’ attention owing to its powerful ROS-scavenging and antioxidant properties. In this study, to avoid rapid degradation and/or depletion of EGCG, we prepare a long-lasting injectable hydrogel by EGCG and hyaluronic acid (HA). The naturally derived hydrogels with excellent biocompatibility and durable retention time can capture the redundant ROS continuously and efficiently, thus protecting ADSCs from ROS-mediated death and bioactivity inhibition, including cell survival, proliferation and chondrogenic differentiation. Intra-articular injection of this ADSCs loaded hydrogel significantly induced synovial macrophages polarization to M2 phenotype, decreased pro-inflammatory cytokines (e.g., IL-1β, MMP-13, and TNF-α) expression, promoted cartilage matrix formation, and repaired cartilage destruction in OA. This stem cell-protected hydrogel delivery strategy showed superior efficacy than ADSCs delivering or EGCG-HA injection singly, which providing a potential alternative strategy for OA management.

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Progress in osteoarthritis research by the National Natural Science Foundation of China

Cited by 21 publications

References 94 publications

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Current understanding of osteoarthritis pathogenesis and relevant new approaches

Naturally derived injectable hydrogels with ROS-scavenging property to protect transplanted stem cell bioactivity for osteoarthritic cartilage repair

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