Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

Abstract

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, codelivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

“…This malignant condition includes cancer of the lip, tongue, mouth, the floor of mouth, and different parts of the oral cavity. [262][263][264] Like other forms of cancer, the aetiology of oral cancer has not been completely elucidated, but it is interesting to mention that, in the light of recent findings, a link between oral microbiota and cancer development has been found. Periodontitis, a disease affecting tooth's supporting tissue, increases the possibility for the development of oral cancer.…”

Nonspherical Metal‐Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity

“…Nanotechnology appeals to researchers and is slowly embraced by the industry. [ 1,2 ] Nanotechnology creates materials with at least 1D between 1 and 100 nm. [ 3,4 ] Metal‐based nanocompounds (MNCs) are designated as materials with overall dimensions that vary between the size of atoms and those of macroscopic bulk materials.…”

Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere as an Efficient Drug Carrier for Cancer Treatment

“…3 Different from radiotherapy and surgical resection, chemotherapy can achieve systemic blood circulation of drugs through oral administration, intravenous injection and targeted delivery system, thereby achieving the effect of systemic treatment. 4,5 Mitomycin-C (MMC) is a commonly used anti-tumor drug, which plays an antagonistic role in deoxyribonucleic acid (DNA) replication after intracellular activation by reductase. 6 A high concentration of MMC can inhibit the synthesis of RNA and protein.…”

“… 3 Different from radiotherapy and surgical resection, chemotherapy can achieve systemic blood circulation of drugs through oral administration, intravenous injection and targeted delivery system, thereby achieving the effect of systemic treatment. 4 , 5 …”