2008
DOI: 10.1128/mmbr.00025-07
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Progress in Metabolic Engineering of Saccharomyces cerevisiae

Abstract: SUMMARY The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has, over time, resulted in substantial accumulated knowledge concerning genetics, physiology, and biochemistry as well as genetic engineering and fermentation technologies. S. cerevisiae has become a platform organism for developing metabolic engineering strategies, methods, and tools. The current review discusses the relevance of several engineering strategies, such as rational and inverse metabolic … Show more

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Cited by 522 publications
(345 citation statements)
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References 416 publications
(455 reference statements)
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“…However, wild-type S. cerevisiae strains are unable to metabolize pentoses (C5 sugars), rendering the utilization of pentoses a significant challenge in biomass-to-ethanol conversion. Considerable research has been devoted to developing genetically modified organisms that co-ferment C6 sugars (hexoses) and C5 sugars to ethanol at high yields [2][3][4][5][6], which has led to commercial-scale co-fermentation being implemented at Poet-DSM's cellulosic ethanol plant in Emmetsburg, Iowa, and the Beta Renewables plant in Crescentino.…”
Section: Introductionmentioning
confidence: 99%
“…However, wild-type S. cerevisiae strains are unable to metabolize pentoses (C5 sugars), rendering the utilization of pentoses a significant challenge in biomass-to-ethanol conversion. Considerable research has been devoted to developing genetically modified organisms that co-ferment C6 sugars (hexoses) and C5 sugars to ethanol at high yields [2][3][4][5][6], which has led to commercial-scale co-fermentation being implemented at Poet-DSM's cellulosic ethanol plant in Emmetsburg, Iowa, and the Beta Renewables plant in Crescentino.…”
Section: Introductionmentioning
confidence: 99%
“…Akibatnya biaya keseluruhan untuk produksi etanol G2 masih jauh lebih mahal daripada biaya produksi etanol generasi pertama (G1) yang bahan bakunya sama dengan bahan pangan. Hal tersebut memacu perkembangan rekayasa genetika, baik untuk memproduksi enzim maupun untuk menghasilkan mikroba unggul, seperti Saccharomyces cerevisiae, yang berkemampuan lebih terutama dalam hal enzimatiknya maupun toleransinya terhadap etanol (Alper et al, 2006;CarleUrioste et al, 1996;Nevoigt, 2008;Stephanopoulos, 2007).…”
Section: Pendahuluanunclassified
“…There are many biomacromolecules and surface charges on the cell wall. They can interact with metal ions or charged ionic groups, provoke the deposition of mineral, provide oriented nucleation sites, immobilize the particles, and finally establish microsphere structure [44].…”
Section: Formation Mechanism Of Lvp/lfp-chmsmentioning
confidence: 99%