Progress in magnetic resonance imaging of autism model mice brain

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by social disorder and stereotypical behaviors with an increasing incidence. ASD patients are suffering from varying degrees of mental retardation and language development abnormalities. Magnetic resonance imaging (MRI) is a noninvasive imaging technology to detect brain structural and functional dysfunction in vivo, playing an important role in the early diagnosisbasic research of ASD. High‐field, small‐animal MRI in basic research of autism model mice has provided a new approach to research the pathogenesis, characteristics, and intervention efficacy in autism. This article reviews MRI studies of mouse models of autism over the past 20 years. Reduced gray matter, abnormal connections of brain networks, and abnormal development of white matter fibers have been demonstrated in these studies, which are present in different proportions in the various mouse models. This provides a more macroscopic view for subsequent research on autism model mice. This article is categorized under: Cognitive Biology > Genes and Environment Neuroscience > Computation Neuroscience > Genes, Molecules, and Cells Neuroscience > Development

Application Value of a Novel Micro-Coil in High-Resolution Imaging of Experimental Mice Based on 3.0 T Clinical MR

“…Animal magnetic resonance imaging (MRI) is a non-invasive in vivo imaging technology with a high spatial and temporal resolution, enabling real-time and repetitive imaging of rodents such as mice in medical experiments, thereby allowing us to obtain a detailed observation of disease changes and trends in animal models [6,7]. MRI in animals has become an attractive method for evaluating the effects of animal models, and it is widely accepted by medical researchers [8,9]. However, animal MRI faces several challenges.…”