Progress in Drying Technology for Nanomaterials

Wang, Baohe; Zhang, Wenbo; Zhang, Wei; Mujumdar, Arun S.; Huang, Li Xin

doi:10.1081/drt-200047900

Cited by 117 publications

(56 citation statements)

References 24 publications

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“…These aggregates may be formed from NP during the drying step as a result of the capillary forces acting on the particles during liquid evaporation. 26 NP aggregation was reported by Van Eerdenburgh et al to be more pronounced for highly hydrophobic surface compounds, such as ITZ. 27 Additionally, TPGS, which is present in a relatively significant proportion (10% w/w of ITZ), could have created semisolid bridges between particles (TPGS melting point is ∼42°C) that would induce agglomeration.…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis

Duret¹,

Wauthoz²,

Sebti³

et al. 2012

IJN

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Correspondence: Christophe Duret Université Libre de Bruxelles (ULB), Boulevard du triomphe campus de la plaine (accès 2), Service de pharmacie galénique et biopharmacie, bat BC niveau 6, Brussels, Belgium Tel +32 650 5331 Fax +32 650 5269 Email cduret@ulb.ac.be Purpose: Itraconazole (ITZ) dry powders for inhalation (DPI) composed of nanoparticles (NP) embedded in carrier microparticles were prepared and characterized. Methods: DPIs were initially produced by reducing the ITZ particle size to the nanometer range using high-pressure homogenization with tocopherol polyethylene 1000 succinate (TPGS, 10% w/w ITZ) as a stabilizer. The optimized nanosuspension and the initial microsuspension were then spray-dried with different proportions of or in the absence of mannitol and/or sodium taurocholate. DPI characterization was performed using scanning electron microscopy for morphology, laser diffraction to evaluate the size-reduction process, and the size of the dried NP when reconstituted in aqueous media, impaction studies using a multistage liquid impactor to determine the aerodynamic performance and fine-particle fraction that is theoretically able to reach the lung, and dissolution studies to determine the solubility of ITZ. Results: Scanning electron microscopy micrographs showed that the DPI particles were composed of mannitol microparticles with embedded nano-or micro-ITZ crystals. The formulations prepared from the nanosuspension exhibited good flow properties and better fine-particle fractions, ranging from 46.2% ± 0.5% to 63.2% ± 1.7% compared to the 23.1% ± 0.3% that was observed with the formulation produced from the initial microsuspension. Spray-drying affected the NP size by inducing irreversible aggregation, which was able to be minimized by the addition of mannitol and sodium taurocholate before the drying procedure. The ITZ NP-based DPI considerably increased the ITZ solubility (58 ± 2 increased to 96 ± 1 ng/mL) compared with that of raw ITZ or an ITZ microparticle-based DPI (,10 ng/mL). Conclusion: Embedding ITZ NP in inhalable microparticles is a very effective method to produce DPI formulations with optimal aerodynamic properties and enhanced ITZ solubility. These formulations could be applied to other poorly water-soluble drugs and could be a very effective alternative for treating invasive pulmonary aspergillosis.

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Section: Physicochemical Propertiesmentioning

confidence: 99%

New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis

Duret¹,

Wauthoz²,

Sebti³

et al. 2012

IJN

View full text Add to dashboard Cite

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“…This is related to the fact that 2-butanol partially replaces the non-bridging hydroxyl groups and thus effectively prevents the agglomeration of particles during the preparation as well as during the drying step. [23,24] Scanning electron microscopy (SEM) pictures ( Figure 2) on ALMAL prepared from Al 2-butoxide and 2-butanol revealed spherical particles in the 19-22 nm range. TGA and ICP data of ALMAL were in good accordance with both the theoretical Al 2 O 3 and Al values (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Dihydroxyaluminum Carboxylate Nanoparticles With Narrow Size Distribution: Synthesis, Characterization and Use for High Optical Transparency Protective Polymeric Coatings

Khalil

Gläsel

Wennrich

et al. 2010

Macro Materials & Eng

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Nano‐sized bis(dihydroxyaluminum)maleate particles (ALMAL) were prepared via a high‐temperature precipitation reaction from different Al‐alkoxides and maleic acid in different solvents. Variations in the reactants were carried out to identify the optimum reaction conditions that lead to particles <30 nm in diameter with narrow particle size distributions and without formation of a secondary amorphous phase. A disc centrifuge was used to characterize the particles in terms of particle size distribution. ALMAL‐containing, epoxy‐based nanocomposites were prepared with ALMAL‐loadings up to 30 wt.‐% and thermally cured. The cured coatings possessed excellent scratch and abrasion resistance, surface hardness and were highly transparent (T>95%). In order to study the effect of the nature of nanoparticles on the final properties of the coatings, aluminum malate (ALMALAT), and aluminum terephthalate (ALTEREPHTHAL) nanoparticles as well as the corresponding composite coatings were prepared and characterized. For comparison, surface‐modified silica nanoparticles were used to evaluate the mechanical and optical behavior of the produced nanocomposite coatings.magnified image

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“…Dissolution profiles of nanosized ITZ formulae in comparison to pure ITZ dried ones. These larger particles may be due to agglomeration of particles during oven drying process (16). The D90 of all of the prepared particles was less than 1 μm, which indicates a narrow size distribution (17).…”

Section: Particle Size Analysismentioning

confidence: 98%

Formulation and Stability Testing of Itraconazole Crystalline Nanoparticles

et al. 2011

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Abstract. Itraconazole (ITZ) crystalline nanoparticles were prepared using relatively simple, low-cost sonoprecipitation technique, in which both the solvent and antisolvent were organic in nature. The effect of stabilizer type (hydroxypropyl methylcellulose, hydroxypropyl cellulose, Inutec SP1®, and pluronic F127), drying method (oven and freeze drying) and matrix former used (Avicel PH101, and Aerosil®200) on the dissolution performance as a key characteristic of nanocrystals was evaluated. In 10 min, all of the prepared nanocrystals showed 3.77−8.59 times improvement in percent drug dissolved compared to pure ITZ. Concerning the effect of stabilizer type, the following rank order can be given: pluronic F127≥ hydroxypropyl cellulose≥hydroxypropyl methylcellulose (HPMC)>inutec SP1. Freeze-dried ITZ nanocrystals containing Avicel PH 101 showed better dissolution rate compared to other nanocrystals. The chemical structure of itraconazole nanocrystals was not changed as revealed by Fourier transform infrared. Stability study of selected nanocrystals (F5, F7, and F8) revealed physical and chemical stability of F7 and F8, while a decrease in dissolution rate of F5 was observed (although being chemically stable) when stored under high relative humidity conditions. Although inutec is less potent than pluronic F127 and HPMC regarding their effect on dissolution rate enhancement, it is equipotent to pluronic F127 in preserving the rapid drug dissolution.

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Progress in Drying Technology for Nanomaterials

Cited by 117 publications

References 24 publications

New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis

New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis

Dihydroxyaluminum Carboxylate Nanoparticles With Narrow Size Distribution: Synthesis, Characterization and Use for High Optical Transparency Protective Polymeric Coatings

Formulation and Stability Testing of Itraconazole Crystalline Nanoparticles

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