Progress in Cue Exposure Therapy for the Treatment of Addictive Disorders: A Review Update~!2009-11-25~!2010-02-08~!2010-04-09~!

Martin, Temeia; LaRowe, Steven D.; Malcolm, Robert

doi:10.2174/1874941001003020092

Cited by 38 publications

(16 citation statements)

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“…From a clinical perspective, this challenges the efficacy of cue-exposure therapy to prevent relapse despite reducing cue reactivity in the clinic 10,11 . Translational laboratory models of human Pavlovian relapse could therefore represent a valuable tool to investigate the mechanisms that mediate relapse and develop new techniques to counteract it 12 .…”

Section: Introductionmentioning

confidence: 99%

Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans

et al. 2019

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Learning accounts of addiction and obesity emphasize the persistent power of Pavlovian reward cues to trigger craving and increase relapse risk. While extinction can reduce conditioned responding, Pavlovian relapse phenomena—the return of conditioned responding following successful extinction—challenge the long-term success of extinction-based treatments. Translational laboratory models of Pavlovian relapse could therefore represent a valuable tool to investigate the mechanisms mediating relapse, although so far human research has mostly focused on return of fear phenomena. To this end we developed an appetitive conditioning paradigm with liquid food rewards in combination with a 3-day design to investigate the return of appetitive Pavlovian responses and the involved neural structures in healthy subjects. Pavlovian conditioning (day 1) was assessed in 62 participants, and a subsample ( n = 33) further completed extinction (day 2) and a reinstatement test (day 3). Conditioned responding was assessed on explicit (pleasantness ratings) and implicit measures (reaction time, skin conductance, heart rate, startle response) and reinstatement effects were further evaluated using fMRI. We observed a return of conditioned responding during the reinstatement test, evident by enhanced skin conductance responses, accompanied by enhanced BOLD responses in the amygdala. On an individual level, psychophysiological reinstatement intensity was significantly anticorrelated with ventromedial prefrontal cortex (vmPFC) activation, and marginally anticorrelated with enhanced amygdala-vmPFC connectivity during late reinstatement. Our results extend evidence from return of fear phenomena to the appetitive domain, and highlight the role of the vmPFC and its functional connection with the amygdala in regulating appetitive Pavlovian relapse.

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Section: Introductionmentioning

confidence: 99%

Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans

et al. 2019

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“…Cue exposure treatment (CET) involves repeated exposure to cues that provoke craving in order to extinguish the urge to smoke (Carter & Tiffany, 1999;Conklin & Tiffany, 2002;Unrod et al, 2014). Virtual reality (VR) has shown many advantages over traditional techniques of exposure (Baumann & Sayette, Advance Access publication June 23, 2014 2006; Bordnick, Yoon, Kaganoff, & Carter, 2013;Kaganoff, Bordnick, & Carter, 2012;Martin, LaRowe, & Malcolm, 2010), but few studies have used cue exposure through VR (VR-CET) in the context of smoking cessation treatments (Choi et al, 2011;Culbertson, Shulenberger, De La Garza, Newton, & Brody, 2012;Girard, Turcotte, Bouchard, & Girard, 2009;Moon & Lee, 2009). As a result, several important questions remain unanswered.…”

mentioning

confidence: 99%

Effects of Systematic Cue Exposure Through Virtual Reality on Cigarette Craving

Pericot‐Valverde

Villa

Gutiérrez-Maldonado

et al. 2014

Nicotine & Tobacco Research

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“…The cues (e.g., ashtray, lighter, glass of beer) can be presented in numerous ways including photographs, video, audio, in vivo, imaginal, virtual, or augmented reality, or as a combination of the preceding exposure methods. Moreover, in addition to external stimuli, exposure to affective cues, such as conditioned emotional states (Stasiewicz and Maisto, 1993;Vinci et al, 2012) or thoughts (Tiffany, 1990), as well as to interoceptive physiological cues (Martin et al, 2010) can be utilized. Measures such as craving, mood, and physiological symptoms are assessed in response to the drug cues, often in comparison to neutral stimuli (Franken et al, 1999).…”

Section: Extinction-based Treatment For Sudmentioning

confidence: 99%

“…Moreover, some studies reported increases in craving and drug use following CET (Lowe et al, 1980;Corty and McFall, 1984;Marissen et al, 2007). A meta-analysis conducted by Conklin and Tiffany (2002) and a systematic review by Martin et al (2010) both concluded that there is no decisive evidence for the use of CET to treat SUD. Explanations for the limited efficacy of CET have generally been associated with processes that hinder extinction (Conklin and Tiffany, 2002).…”

Section: Limited Efficacy and Effectiveness For The Treatment Of Sudsmentioning

confidence: 99%

Minding the Gap: Leveraging Mindfulness to Inform Cue Exposure Treatment for Substance Use Disorders

2021

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Despite extinction-based processes demonstrating efficacy in the animal extinction and human anxiety literatures, extinction for substance use disorders (SUD) has shown poor efficacy (i. e., cue exposure treatment [CET]). Reasons for this lack of success include common threats to extinction, such as renewal and reinstatement. In recent decades, research on mindfulness for SUD has flourished, and a key aspect of these mindfulness-based interventions includes teaching individuals to stay present with whatever experience they have, even if unpleasant, without trying to change/escape/avoid it. Similarly, CET teaches individuals to not escape/avoid conditioned responses (e.g., craving) by engaging in drug use behavior. This paper discusses how mindfulness-based research and practices could positively influence CET through future research (e.g., Could mindfulness practice attenuate renewal? Might mindfulness training + CET enhance the ability to extinguish the most salient or motivational cues?), with the long-term goal of improving SUD treatment.

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Progress in Cue Exposure Therapy for the Treatment of Addictive Disorders: A Review Update~!2009-11-25~!2010-02-08~!2010-04-09~!

Cited by 38 publications

References 0 publications

Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans

Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans

Effects of Systematic Cue Exposure Through Virtual Reality on Cigarette Craving

Minding the Gap: Leveraging Mindfulness to Inform Cue Exposure Treatment for Substance Use Disorders

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