Progress in controllable bioorthogonal catalysis for prodrug activation

Liu, Xia; Huang, Tingjing; Chen, Zhaowei; Yang, Huanghao

doi:10.1039/d3cc04286c

Chem. Commun.

2023

DOI: 10.1039/d3cc04286c

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Progress in controllable bioorthogonal catalysis for prodrug activation

Xia Liu,

Tingjing Huang,

Zhaowei Chen

et al.

Abstract: Bioorthogonal catalysis, a class of catalytic reactions that are mediated by abiotic metals and proceed in biological environments without interfering with naive biochemical reactions, has gained ever-increasing momentum in prodrug...

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2024

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Cited by 4 publications

References 96 publications

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Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Zhang,

Zhu,

Ren

et al. 2024

Advanced Materials

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Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology in recent years, bioorthogonal nanozymes are innovated to tackle the challenges that emerged in practical biomedical applications. Bioorthogonal nanozymes are uniquely positioned owing to their advantages of high customizability and tunability, as well as good adaptability to biological systems, which bring exciting opportunities for biomedical applications. More intriguingly, the great advancement in nanotechnology offers an exciting opportunity for innovating bioorthogonal catalytic materials. In this comprehensive review, the significant progresses of bioorthogonal nanozymes are discussed with both spatiotemporal controllability and high performance in living systems, and highlight their design principles and recent rapid applications. The remaining challenges and future perspectives are then outlined along this thriving field. It is expected that this review will inspire and promote the design of novel bioorthogonal nanozymes, and facilitate their clinical translation.

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Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Zhang,

Zhu,

Ren

et al. 2024

Advanced Materials

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Cancer therapy by nano MIL-n series of metal-organic frameworks

Karimi Alavijeh,

Akhbari

2024

Coordination Chemistry Reviews

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Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications

Zhang,

Lei,

Qian

et al. 2024

Journal of Controlled Release

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Progress in controllable bioorthogonal catalysis for prodrug activation

Abstract: Bioorthogonal catalysis, a class of catalytic reactions that are mediated by abiotic metals and proceed in biological environments without interfering with naive biochemical reactions, has gained ever-increasing momentum in prodrug...

Cited by 4 publications

References 96 publications

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Cancer therapy by nano MIL-n series of metal-organic frameworks

Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications

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