Progress in clinical research on the integration of Chinese and Western medicines for treating primary liver cancer

Liu, Kaiqi; Li, Hongliang; Duan, Jufeng; Chen, Xiaojing; Yu, Xuanji; Wang, Xianhe; Liu, Ming; Li, Bei; Li, Minglun; Feng, Yibin; Cai, Xiaojun; Wang, Xuanbin

doi:10.1016/j.jtcms.2021.07.001

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…However, in the remaining 33, a statistical difference was observed indicating enhanced curative effects and improvements in the quality of life. Although promising, the authors acknowledged that larger, stricter trials would be needed in order to draw definitive conclusions ( Liu et al, 2021 ). A similar tone in the discussion on the use of TCM for cardiovascular disease can be seen from the literature.…”

Section: Safety Standardization and Clinical Trialsmentioning

confidence: 99%

East Wind, West Wind: Toward the modernization of traditional Chinese medicine

Yagüe

Sun²,

Hu³

2022

Front. Neurosci.

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Traditional Chinese medicine (TCM) has used herbal remedies for more than 2,000 years. The use of complimentary therapies has increased dramatically during the last years, especially in the West, and the incorporation and modernization of TCM in current medical practice is gaining momentum. We reflect on the main bottlenecks in the modernization of arcane Chinese herbal medicine: lack of standardization, safety concerns and poor quality of clinical trials, as well as the ways these are being overcome. Progress in these areas will facilitate the implementation of an efficacy approach, in which only successful clinical trials lead to the molecular characterization of active compounds and their mechanism of action. Traditional pharmacological methodologies will produce novel leads and drugs, and we describe TCM successes such as the discovery of artemisinin as well as many others still in the pipeline. Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease, cancer and cardiovascular disease are the main cause of mortality in the Western world and, with an increasing old population in South East Asia, this trend will also increase in the Far East. TCM has been used for long time for treating these diseases in China and other East Asian countries. However, the holistic nature of TCM requires a paradigm shift. By changing our way of thinking, from “one-target, one-drug” to “network-target, multiple-component-therapeutics,” network pharmacology, together with other system biology methodologies, will pave the way toward TCM modernization.

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Section: Safety Standardization and Clinical Trialsmentioning

confidence: 99%

East Wind, West Wind: Toward the modernization of traditional Chinese medicine

Yagüe

Sun²,

Hu³

2022

Front. Neurosci.

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“…However, it was difficult for the research community to explore the effects, and particularly the underlying mechanisms of tonics due to their multiple components ( Yang et al, 2018 ; Yang et al, 2019 ), complex pharmacokinetic (PK) processes ( Wang et al, 2021a ; Wang et al, 2021b ), and multiple targets until OMICs were introduced ( Li et al, 2019 ; Wang et al, 2019 ; Wang and Lu, 2019 ; Li et al, 2020 ; Liu et al, 2021a ; Li et al, 2022b ). OMICs are novel technologies that have been dramatically developed in the last 2 decades.…”

Section: Introductionmentioning

confidence: 99%

Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action

Zuo

Jia

et al. 2022

Front. Pharmacol.

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Gastric, liver, and colorectal cancers belong to gastrointestinal (GI) cancers, one of the most threatening diseases in the world. The tonics class in Chinese medicines plays a critical role in antigastrointestinal cancer as adjuvants. However, it is a challenge to study the effects and underlying mechanisms of tonics due to their multiple components and multiple targets; OMICs were introduced to facilitate the investigation of the complex mixture of tonics. In this review, the online databases PubMed, ProQuest, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Chongqing VIP, and Wanfang were retrieved from 1 January 2011 to 31 May 2022, in an aim to summarize and discuss the research progress of the effects and, especially, the underlying mechanisms of tonics for antigastrointestinal cancers via OMICs. The results showed that through the combination of OMICs and other technologies, tonics have been used for gastrointestinal cancer by targeting cancer hallmarks, enhancing body resistance to carcinogenesis, enhancing therapeutic effects, and/or decreasing side effects. In conclusion, tonics may play a promising role in gastric, liver, and colorectal cancers as adjuvants and can be well investigated via the combination of OMICs and other technologies, which deserves further study.

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Research Progress of Traditional Chinese Medicine in Improving Survival and Prognosis of Advanced Primary Liver Cancer

丁

2023

TCM

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Progress in clinical research on the integration of Chinese and Western medicines for treating primary liver cancer

Cited by 3 publications

References 12 publications

East Wind, West Wind: Toward the modernization of traditional Chinese medicine

East Wind, West Wind: Toward the modernization of traditional Chinese medicine

Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers—OMICs-based contributions to understanding their mechanism of action

Research Progress of Traditional Chinese Medicine in Improving Survival and Prognosis of Advanced Primary Liver Cancer

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