“…DTdiaphorase is induced in many tissues by a wide variety of structurally dissimilar chemicals, including 1,2-dithiole-3-thiones (D3Ts), quinones, diphenols, phenylenediamines, Michael reaction acceptors, isothiocyanates and heavy metals (Prestera et al, 1993). Thus, studies have investigated the use of inducers of DTdiaphorase and other phase II detoxifying enzymes in cancer prevention (Kelloff et al, 1990; Kensler and Helzlsouer, 1995). Oltipraz, a D3T analogue used for treatment of schistosomiasis (Bueding et al, 1982), is an inducer of phase II detoxifying enzymes (Kensler et al, 1992;Egner et al, 1994;Kensler and Helzlsouer, 1995) and inhibits development of tumours in animals (Kelloff et al, 1990; Kensler et al, 1992; Kensler and Helzlsouer, 1995).…”