Progress in bioprinting technology for tissue regeneration

Sabzevari, Alireza; Pisheh, Hossein Rayat; Ansari, Mojtaba; Salati, Amir

doi:10.1007/s10047-023-01394-z

Cited by 14 publications

(10 citation statements)

References 183 publications

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“…Several synthetic biomaterials currently used for cartilage tissue engineering include polyvinyl alcohol (PVA) ( Bonakdar et al, 2010 ), PEG ( Yang et al, 2015 ; Fan et al, 2016 ), polypropylene fumarate (PPF) ( Kallukalam et al, 2008 ), poly (L-glutamic acid) ( Yan et al, 2014 ; Yang et al, 2016 ), α,β-poly-(N-hydroxyethyl)-DL-aspartamide ( Sun et al, 2009 ), methoxypolyethylene glycol-poly (ε-caprolactone) ( Kwon et al, 2013a ), and PEG-poly (N-isopropylacrylamide) (PNIPAAm) ( Alexander et al, 2014 ). Among these polymers, PVA has been recognized as a promising candidate for cartilage repair due to its unique properties such as non-toxicity, good biocompatibility, and water solubility ( Semsarzadeh and Sabzevari, 2018 ; Semsarzadeh and Sabzevari, 2020 ; Chen et al, 2021 ; Sabzevari et al, 2023 ). Well-defined PVA can be easily synthesized using cobalt-mediated radical polymerization of vinyl acetate and then hydrolysis of polyvinyl acetate ( Semsarzadeh et al, 2018 ; Sabzevari et al, 2022a ; Sabzevari et al, 2022b ; Sabzevari et al, 2023 ).…”

Section: Injectable Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

“…Among these polymers, PVA has been recognized as a promising candidate for cartilage repair due to its unique properties such as non-toxicity, good biocompatibility, and water solubility ( Semsarzadeh and Sabzevari, 2018 ; Semsarzadeh and Sabzevari, 2020 ; Chen et al, 2021 ; Sabzevari et al, 2023 ). Well-defined PVA can be easily synthesized using cobalt-mediated radical polymerization of vinyl acetate and then hydrolysis of polyvinyl acetate ( Semsarzadeh et al, 2018 ; Sabzevari et al, 2022a ; Sabzevari et al, 2022b ; Sabzevari et al, 2023 ). Like PVA, polyethylene glycol (PEG) is a hydrophilic polymer that is highly soluble in water.…”

Section: Injectable Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

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A review of advanced hydrogels for cartilage tissue engineering

Ansari,

Darvishi,

Sabzevari

2024

Front. Bioeng. Biotechnol.

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With the increase in weight and age of the population, the consumption of tobacco, inappropriate foods, and the reduction of sports activities in recent years, bone and joint diseases such as osteoarthritis (OA) have become more common in the world. From the past until now, various treatment strategies (e.g., microfracture treatment, Autologous Chondrocyte Implantation (ACI), and Mosaicplasty) have been investigated and studied for the prevention and treatment of this disease. However, these methods face problems such as being invasive, not fully repairing the tissue, and damaging the surrounding tissues. Tissue engineering, including cartilage tissue engineering, is one of the minimally invasive, innovative, and effective methods for the treatment and regeneration of damaged cartilage, which has attracted the attention of scientists in the fields of medicine and biomaterials engineering in the past several years. Hydrogels of different types with diverse properties have become desirable candidates for engineering and treating cartilage tissue. They can cover most of the shortcomings of other treatment methods and cause the least secondary damage to the patient. Besides using hydrogels as an ideal strategy, new drug delivery and treatment methods, such as targeted drug delivery and treatment through mechanical signaling, have been studied as interesting strategies. In this study, we review and discuss various types of hydrogels, biomaterials used for hydrogel manufacturing, cartilage-targeting drug delivery, and mechanosignaling as modern strategies for cartilage treatment.

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Section: Injectable Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

Section: Injectable Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

A review of advanced hydrogels for cartilage tissue engineering

Ansari,

Darvishi,

Sabzevari

2024

Front. Bioeng. Biotechnol.

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“…The 3D bioprinting process is based on the premise of layer-by-layer deposition on constructs. In essence, it dispenses or prints a liquid, a viscous fluid called the bioink in intricate layers to form a predesigned construct like the intended tissue ( Murphy and Atala, 2014 ; Peng et al, 2016 ; Ma et al, 2018 ; Sabzevari et al, 2023 ). The bioprinting process works through the extrusion of a bioink or hydrogel biomaterial combined with human cells from various sources in a bottom-up, layer-by-layer fashion until a 3D construct is built.…”

Section: 3d Bioprinting Technologies and Strategiesmentioning

confidence: 99%

“…This strategy can print low-viscosity bioink rapidly in high resolution. However, it is hampered by being able to form consistent droplets and uniformly encapsulate cells ( Gudapati et al, 2016 ; Leberfinger et al, 2017 ; Sabzevari et al, 2023 ). Inkjet bioprinting is a form of droplet-based bioprinting that uses a hydrogel-based bioink in a print cartridge that is connected to the printer head ( Figure 3 ).…”

Section: 3d Bioprinting Technologies and Strategiesmentioning

confidence: 99%

The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models

Du Plessis,

Gouws,

Nieto

2024

Front. Cell Dev. Biol.

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Various in vitro three-dimensional (3D) tissue culture models of human and diseased skin exist. Nevertheless, there is still room for the development and improvement of 3D bioprinted skin cancer models. The need for reproducible bioprinting methods, cell samples, biomaterial inks, and bioinks is becoming increasingly important. The influence of the viscosity of hydrogels on the spreading and migration of most types of cancer cells is well studied. There are however limited studies on the influence of viscosity on the spreading and migration of cells in 3D bioprinted skin cancer models. In this review, we will outline the importance of studying the various types of skin cancers by using 3D cell culture models. We will provide an overview of the advantages and disadvantages of the various 3D bioprinting technologies. We will emphasize how the viscosity of hydrogels relates to the spreading and migration of cancer cells. Lastly, we will give an overview of the specific studies on cell migration and spreading in 3D bioprinted skin cancer models.

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“…Implantation of tissue ‘engineered’ in vitro by seeding cultured cells into a biomaterial scaffold, replacing or renewing functional tissue, could be achieved. Researchers tried fabricating a three-dimensional (3D) cell-laden matrix to develop functional replacement tissues [ 10 , 11 , 12 , 13 ]. However, few were successful in their in vitro development, and fewer were applied to test their effectiveness for in vivo conditions because of evident limitations [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Fabrication of 3-D Cell Laden Micro-Patterned Porous Structure on Cell Growth and Proliferation by Layered Manufacturing

Chu,

Park,

Moon

2023

Bioengineering

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This study focuses on developing and characterizing a novel 3-dimensional cell-laden micro-patterned porous structure from a mechanical engineering perspective. Tissue engineering holds great promise for repairing damaged organs but faces challenges related to cell viability, biocompatibility, and mechanical strength. This research aims to overcome these limitations by utilizing gelatin methacrylate hydrogel as a scaffold material and employing a photolithography technique for precise patterned fabrication. The mechanical properties of the structure are of particular interest in this study. We evaluate its ability to withstand external forces through compression tests, which provide insights into its strength and stability. Additionally, structural integrity is assessed over time to determine its performance in in vitro and potential in vivo environments. We investigate cell viability and proliferation within the micro-patterned porous structure to evaluate the biological aspects. MTT assays and immunofluorescence staining are employed to analyze the metabolic activity and distribution pattern of cells, respectively. These assessments help us understand the effectiveness of the structure in supporting cell growth and tissue regeneration. The findings of this research contribute to the field of tissue engineering and provide valuable insights for mechanical engineers working on developing scaffolds and structures for regenerative medicine. By addressing challenges related to cell viability, biocompatibility, and mechanical strength, we move closer to realizing clinically viable tissue engineering solutions. The novel micro-patterned porous structure holds promise for applications in artificial organ development and lays the foundation for future advancements in large soft tissue construction.

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Progress in bioprinting technology for tissue regeneration

Cited by 14 publications

References 183 publications

A review of advanced hydrogels for cartilage tissue engineering

A review of advanced hydrogels for cartilage tissue engineering

The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models

Novel Fabrication of 3-D Cell Laden Micro-Patterned Porous Structure on Cell Growth and Proliferation by Layered Manufacturing

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