Progress, challenges and future directions of heterocycles as building blocks in iterative methodologies towards sequence-defined oligomers and polymers

Hill, Stephen A.; Steinfort, Robert; Hartmann, Laura

doi:10.1039/d1py00425e

Cited by 13 publications

(8 citation statements)

References 140 publications

(145 reference statements)

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“…In fact, living polymerisation analogues are not often used to assemble sequence-defined macromolecules. 212 The classic examples of this are syntheses not typically associated with polymer chemistry, namely, that of peptides and nucleotides. 213,214 In order to synthesise polymers with a greater variety of main chain compositions, numerous such high-yielding/ robust reactions have been applied in this space.…”

Section: Perspectivementioning

confidence: 99%

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The challenges of controlling polymer synthesis at the molecular and macromolecular level

Hakobyan

Müllner

2022

Polym. Chem.

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Section: Perspectivementioning

confidence: 99%

Section: Sequencementioning

confidence: 99%

The challenges of controlling polymer synthesis at the molecular and macromolecular level

Hakobyan

Müllner

2022

Polym. Chem.

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“…The great potential inherent in foldamers results from the possibility of extending the alphabet with abiotic monomers. Furthermore, the development of precision polymer chemistry methods [ 154 , 155 , 156 ] leading to sequence-defined macromolecules provides opportunities for new types of foldamers based on an abiotic backbone [ 157 , 158 , 159 , 160 , 161 ].…”

Section: Foldamers In Sensingmentioning

confidence: 99%

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

et al. 2022

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Sensors are tools for detecting, recognizing, and recording signals from the surrounding environment. They provide measurable information on chemical or physical changes, and thus are widely used in diagnosis, environment monitoring, food quality checks, or process control. Polymers are versatile materials that find a broad range of applications in sensory devices for the biomedical sector and beyond. Sensory materials are expected to exhibit a measurable change of properties in the presence of an analyte or a stimulus, characterized by high sensitivity and selectivity of the signal. Signal parameters can be tuned by material features connected with the restriction of macromolecule shape by crosslinking or folding. Gels are crosslinked, three-dimensional networks that can form cavities of different sizes and forms, which can be adapted to trap particular analytes. A higher level of structural control can be achieved by foldamers, which are macromolecules that can attain well-defined conformation in solution. By increasing control over the three-dimensional structure, we can improve the selectivity of polymer materials, which is one of the crucial requirements for sensors. Here, we discuss various examples of polymer gels and foldamer-based sensor systems. We have classified and described applied polymer materials and used sensing techniques. Finally, we deliberated the necessity and potential of further exploration of the field towards the increased selectivity of sensory devices.

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“…In the last decades, various methodologies have been developed to prepare SDPs. ,− Notably, the solid-phase strategy has become a foundational method due to its straightforward procedures and efficient removal of byproducts, ,,− which was pioneered by Merrifield and colleagues in 1963 for peptide synthesis . A significant advancement in solid-phase strategy is the adoption of phosphoramidite chemistry to prepare commercial oligonucleotides, which has revolutionized the biological field.…”

Section: Introductionmentioning

confidence: 99%

Advanced Smart Biomaterials for Regenerative Medicine and Drug Delivery Based on Phosphoramidite Chemistry: From Oligonucleotides to Precision Polymers

Yang,

Cui,

Guo

et al. 2024

Biomacromolecules

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Over decades of development, while phosphoramidite chemistry has been known as the leading method in commercial synthesis of oligonucleotides, it has also revolutionized the fabrication of sequence-defined polymers (SDPs), offering novel functional materials in polymer science and clinical medicine. This review has introduced the evolution of phosphoramidite chemistry, emphasizing its development from the synthesis of oligonucleotides to the creation of universal SDPs, which have unlocked the potential for designing programmable smart biomaterials with applications in diverse areas including data storage, regenerative medicine and drug delivery. The key methodologies, functions, biomedical applications, and future challenges in SDPs, have also been summarized in this review, underscoring the significance of breakthroughs in precisely synthesized materials.

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Progress, challenges and future directions of heterocycles as building blocks in iterative methodologies towards sequence-defined oligomers and polymers

Abstract: The synthesis of sequence-defined oligomers and polymers is an important contemporary research topic due to the potential for creating materials with function tailored directly into the primary structure. Sequence-defined materials...

Cited by 13 publications

References 140 publications

The challenges of controlling polymer synthesis at the molecular and macromolecular level

The challenges of controlling polymer synthesis at the molecular and macromolecular level

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

Advanced Smart Biomaterials for Regenerative Medicine and Drug Delivery Based on Phosphoramidite Chemistry: From Oligonucleotides to Precision Polymers

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