Progress and Trends in Artificial Silk Spinning: A Systematic Review

Koeppel, Andreas; Holland, Chris

doi:10.1021/acsbiomaterials.6b00669

Cited by 191 publications

(251 citation statements)

References 132 publications

(318 reference statements)

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“…Silk fibers produced by silkworms and spiders possess exceptional mechanical properties that exceeds many synthetic polymers . Numerous efforts have been devoted to mimicking the fiber production process by the insects using regenerated silk solutions . However, the as‐spun regenerated silk fibers (RSF) are usually brittle and requires complex post‐treatment (e.g., dehydration and crystallization processes) to yield useful fibers .…”

Section: Multiscale Manufacturingmentioning

confidence: 99%

Engineering the Future of Silk Materials through Advanced Manufacturing

et al. 2018

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Silk is a natural fiber renowned for its outstanding mechanical properties that have enabled the manufacturing of ultralight and ultrastrong textiles. Recent advances in silk processing and manufacturing have underpinned a re-interpretation of silk from textiles to technological materials. Here, it is argued that silk materials-optimized by selective pressure to work in the environment at the biotic-abiotic interface-can be harnessed by human micro- and nanomanufacturing technology to impart new functionalities and opportunities. A critical overview of recent progress in silk technology is presented with emphasis on high-tech applications enabled by recent innovations in multilevel modifications, multiscale manufacturing, and multimodal characterization of silk materials. These advances have enabled successful demonstrations of silk materials across several disciplines, including tissue engineering, drug delivery, implantable medical devices, and biodissolvable/degradable devices.

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Section: Multiscale Manufacturingmentioning

confidence: 99%

Engineering the Future of Silk Materials through Advanced Manufacturing

et al. 2018

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“…The results indicated that the highly condensed BSA network crosslinked by GA plays an important role in increasing the fibers' strength and toughness. Notably, this outstanding toughness is already at the same level as the spider dragline silk and is even superior to that of many recombinant spider silks and regenerated silkworm fibers . Meanwhile, the Young's moduli of the fibers are ≈3 GPa (Figure S20, Supporting Information), indicating the preserved stiffness in the BSA fibers.…”

Section: Resultsmentioning

confidence: 90%

Robust Biological Fibers Based on Widely Available Proteins: Facile Fabrication and Suturing Application

Zhang

Sun

et al. 2020

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Lightweight and mechanically strong protein fibers are promising for many technical applications. Despite the widespread investigation of biological fibers based on spider silk and silkworm proteins, it remains a challenge to develop low‐cost proteins and convenient spinning technology for the fabrication of robust biological fibers. Since there are plenty of widely available proteins in nature, it is meaningful to investigate the preparation of fibers by the proteins and explore their biomedical applications. Here, a facile microfluidic strategy is developed for the scalable construction of biological fibers via a series of easily accessible spherical and linear proteins including chicken egg, quail egg, goose egg, bovine serum albumin, milk, and collagen. It is found that the crosslinking effect in microfluidic chips and double‐drawn treatment after spinning are crucial for the formation of fibers. Thus, high tensile strength and toughness are realized in the fibers, which are comparable or even higher than that of many recombinant spider silks or regenerated silkworm fibers. Moreover, the suturing applications in rat and minipig models are realized by employing the mechanically strong fibers. Therefore, this work opens a new direction for the production of biological fibers from natural sources.

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“…Meanwhile, the breaking strength was approximately 130 MPa and the toughness increased to approximately 143 MJ m −3 (Figure B). The present toughness of GBF is in the same level as the spider dragline silk (approximately 150 MJ m −3 ) and is even superior to that of many recombinant spider silks and regenerated silkworm fibers . Notably, the toughness of the double GA‐crosslinked GBF was at least 70 times higher than the PBF and one‐time GA crosslinked GBF.…”

Section: Figurementioning

confidence: 80%

Mechanically Strong Globular‐Protein‐Based Fibers Obtained Using a Microfluidic Spinning Technique

Yang

Wang

et al. 2020

Angew Chem Int Ed

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Proteins used for the formation of light weight and mechanically strong biological fibers are typically composed of folded rigid and unfolded flexible units. In contrast to fibrous proteins, globular proteins are generally not regarded as a good candidate for fiber production due to their intrinsic structural defects. Thus, it is challenging to develop an efficient strategy for the construction of mechanically strong fibers using spherical proteins. Herein, we demonstrate the production of robust protein fibers from bovine serum albumin (BSA) using a microfluidic technique. Remarkably, the toughness of the fibers was up to 143 MJ m−3, and after post‐stretching treatment, their breaking strength increased to almost 300 MPa due to the induced long‐range ordered structure in the fibers. The performance is comparable to or even higher than that of many recombinant spider silks or regenerated silkworm fibers. Thus, this work opens a new way for making biological fibers with high performance.

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Progress and Trends in Artificial Silk Spinning: A Systematic Review

Cited by 191 publications

References 132 publications

Engineering the Future of Silk Materials through Advanced Manufacturing

Engineering the Future of Silk Materials through Advanced Manufacturing

Robust Biological Fibers Based on Widely Available Proteins: Facile Fabrication and Suturing Application

Mechanically Strong Globular‐Protein‐Based Fibers Obtained Using a Microfluidic Spinning Technique

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