Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product

Guo, Xiaolei; Ma, Yuan; Yang, Min; Sun, Jing; Shi, Xinli; Gao, Guobiao; Wang, Jiadao

doi:10.1016/j.bioactmat.2022.06.015

Cited by 27 publications

(23 citation statements)

References 133 publications

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“…[3] Given the comprehensive sources of biomaterials and seed cells, which are conducive to large-scale cultivation in vitro, tissue-engineering cartilage owns advantageous capacities to repair large tissue defects and avoid donor complications and two-stage invasive surgical procedures. [4] Hydrogels are emerging as a promising biological scaffold due to their hydrated 3D architectures, better biocompatibility, biodegradability, bioactivity, and abundance from diverse sources. [5] However, inherently low mechanical strength greatly precludes their applications, especially in load-bearing tissue substitutes.…”

Section: Introductionmentioning

confidence: 99%

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Kartogenin‐Conjugated Double‐Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair

et al. 2022

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The effectiveness of existing tissue-engineering cartilage (TEC) is known to be hampered by weak integration of biocompatibility, biodegradation, mechanical strength, and microenvironment supplies. The strategy of hydrogel-based TEC holds considerable promise in circumventing these problems. Herein, a non-toxic, biodegradable, and mechanically optimized double-network (DN) hydrogel consisting of polyethylene glycol (PEG) and kartogenin (KGN)-conjugated chitosan (CHI) is constructed using a simple soaking strategy. This PEG-CHI-KGN DN hydrogel possesses favorable architectures, suitable mechanics, remarkable cellular affinity, and sustained KGN release, which can facilitate the cartilage-specific genes expression and extracellular matrix secretion of peripheral blood-derived mesenchymal stem cells (PB-MSCs). Notably, after tracing the transplanted cells by detecting the rabbit sex-determining region Y-linked gene sequence, the allogeneic PB-MSCs are found to survive for even 3 months in the regenerated cartilage. Here, the long-term release of KGN is able to efficiently and persistently activate multiple genes and signaling pathways to promote the chondrogenesis, chondrocyte differentiation, and survival of PB-MSCs. Thus, the regenerated tissues exhibit well-matched histomorphology and biomechanical performance such as native cartilage. Consequently, it is believed this innovative work can expand the choice for developing the next generation of orthopedic implants in the loadbearing region of a living body.

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Section: Introductionmentioning

confidence: 99%

“…[ 3 ] Given the comprehensive sources of biomaterials and seed cells, which are conducive to large‐scale cultivation in vitro, tissue‐engineering cartilage owns advantageous capacities to repair large tissue defects and avoid donor complications and two‐stage invasive surgical procedures. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

Kartogenin‐Conjugated Double‐Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair

et al. 2022

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“…However, it is not well defined the calibration of the toughness and hardness, for the resistance to wear. In addition to mineralization, data on cartilage crosslinks in engineered or repair cartilages are not defined and described yet ( 118 , 119 ). The next step of the use of new cartilage will be the durability test.…”

Section: Discussionmentioning

confidence: 99%

“…The next step of the use of new cartilage will be the durability test. However, though currently healing of cartilage defects continues to be elusive, given that emerging technologies are being validated clinically, the field is primed for an explosion of cartilage regeneration techniques that should excite those suffering from cartilage afflictions ( 118 ). Furthermore, while osteoarthritis is currently an intractable problem, exciting new discoveries bode well for the eventual healing of a problem that afflicts a quarter of our adult population.…”

Section: Discussionmentioning

confidence: 99%

The sternum reconstruction: Present and future perspectives

et al. 2022

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Sternectomy is a procedure mainly used for removing tumor masses infiltrating the sternum or treating infections. Moreover, the removal of the sternum involves the additional challenge of performing a functional reconstruction. Fortunately, various approaches have been proposed for improving the operation and outcome of reconstruction, including allograft transplantation, using novel materials, and developing innovative surgical approaches, which promise to enhance the quality of life for the patient. This review will highlight the surgical approaches to sternum reconstruction and the new perspectives in the current literature.

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“…Moreover, various surgical techniques, such as microfracture and allogenic and autologous cartilage transplantation, have been used to repair articular-cartilage defects [ 4 , 5 ]. However, such treatments have the potential to cause more severe issues, including graft rejection, disease spread, infection, pain, bone nonunion, and osteonecrosis [ 6 , 7 , 8 , 9 , 10 ], and the long-term survival of grafts remains uncertain [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Applications of Stimuli-Responsive Hydrogels in Bone and Cartilage Regeneration

Xing

Deng

et al. 2023

Pharmaceutics

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Bone and cartilage regeneration is an area of tremendous interest and need in health care. Tissue engineering is a potential strategy for repairing and regenerating bone and cartilage defects. Hydrogels are among the most attractive biomaterials in bone and cartilage tissue engineering, mainly due to their moderate biocompatibility, hydrophilicity, and 3D network structure. Stimuli-responsive hydrogels have been a hot topic in recent decades. They can respond to external or internal stimulation and are used in the controlled delivery of drugs and tissue engineering. This review summarizes current progress in the use of stimuli-responsive hydrogels in bone and cartilage regeneration. The challenges, disadvantages, and future applications of stimuli-responsive hydrogels are briefly described.

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Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product

Cited by 27 publications

References 133 publications

Kartogenin‐Conjugated Double‐Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair

Kartogenin‐Conjugated Double‐Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair

The sternum reconstruction: Present and future perspectives

Applications of Stimuli-Responsive Hydrogels in Bone and Cartilage Regeneration

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