Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery

Bai, Meng Yi; Yang, Mingshi; Gong, Junbo; Xu, Huaizhe; Wei, Zihao

doi:10.1208/s12249-021-02200-w

Cited by 19 publications

(8 citation statements)

References 123 publications

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“…To improve therapeutic potency and minimize the side effects, more targeted therapies are highly needed ( Perez-Herrero and Fernandez-Medarde, 2015 ). Under this circumstance, researchers around the world have explored a variety of new nanocarriers and targeted modification systems to overcome these shortcomings and improve the therapeutic outcomes ( Ghaz-Jahanian et al, 2015 ; Bai et al, 2021 ; Shakeran et al, 2021 ; Dubey et al, 2022 ). Because nanotechnology provides a suitable means for the targeted and time-controlled delivery of drugs and other bioactive agents, it has been widely studied in drug delivery and has potential application prospects in cancer treatment ( Sabra et al, 2017 ; George et al, 2019 ; Ion et al, 2021 ; Maspes et al, 2021 ; Sohrabi and Packirisamy, 2021 ; Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

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Cancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemotherapy for most cancers still faces many problems associated with a lot of adverse effects, which limit its therapeutic potency, low survival quality and discount cancer prognosis. In order to decrease these side effects and improve treatment effectiveness and patient’s compliance, more targeted treatments are needed. Sustainable and controlled deliveries of drugs with controllable toxicities are expected to address these hurdles. Chitosan is the second most abundant natural polysaccharide, which has excellent biocompatibility and notable antitumor activity. Its biodegradability, biocompatibility, biodistribution, nontoxicity and immunogenicity free have made chitosan become a widely used polymer in the pharmacology, especially in oncotherapy. Here, we make a brief review of the main achievements in chitosan and its derivatives in pharmacology with a special focus on their agents delivery applications, immunomodulation, signal pathway modulation and antitumor activity to highlight their role in cancer treatment. Despite a large number of successful studies, the commercialization of chitosan copolymers is still a big challenge. The further development of polymerization technology may satisfy the unmet medical needs.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

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“…This targeted approach enhances the accumulation of therapeutic agents at the tumor site while minimizing off-target effects, thereby improving the efficacy and safety of cancer treatments. 87 The anticancer potential of CeVO 4 NPs has been studied in previous research. In order to keep an inhibitor from interacting directly with the sol-gel matrix, Shchukin et al developed nanometer-scale reservoirs for it.…”

Section: Toxicity and Biocompatibility Of Cevo 4 Npsmentioning

confidence: 99%

“…These NPs can disrupt the cytoskeletal organization, inhibit cell adhesion to the extracellular matrix, and suppress the expression of proteins involved in migration and invasion pathways. 19,87 CeVO 4 NPs can interfere with matrix metalloproteinases (MMPs), which play a crucial role in cancer cell invasion, by downregulating their expression or inhibiting their enzymatic activity. Consequently, CeVO 4 NPs hinder the ability of cancer cells to migrate and invade surrounding tissues.…”

Section: Toxicity and Biocompatibility Of Cevo 4 Npsmentioning

confidence: 99%

“…96 To sum up, CeVO 4 NPs exhibit significant anticancer activity through various mechanisms, including inhibition of angiogenesis, induction of apoptosis, and inhibition of migration and invasion. 87 These NPs can be further modified by doping with other elements or loading drugs or biomolecules to enhance their anticancer properties. The utilization of CeVO 4 NPs as a potential therapeutic tool holds promise for developing innovative and effective cancer treatment strategies.…”

Section: Anticancer Activity Of Cevo4 Npsmentioning

confidence: 99%

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Biomedical applications of cerium vanadate nanoparticles: a review

Farasati Far,

Maleki-baladi,

Fathi-karkan

et al. 2024

J. Mater. Chem. B

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“…Nanomaterials can be produced into a variety of spatial structures, morphology, forms, and surface modification based on their intrinsic thermal, electrical, magnetic, and optical physical properties. Nanomaterial is widely used as a theranostic agent in PTT (photothermal therapy) (Huang et al, 2021), PDT (photodynamic therapy) (Bharathiraja et al, 2018;Wu et al, 2021), CDT (chemodynamic therapy) (Wang et al, 2022;Yang et al, 2022), and NDDS (Bai et al, 2021;Foglietta et al, 2021) to overcome the limitations of standard cancer treatments.…”

Section: Introductionmentioning

confidence: 99%

Recent Advance in Tumor Microenvironment-Based Stimuli-Responsive Nanoscale Drug Delivery and Imaging Platform

et al. 2022

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The tumor microenvironment (TME) plays an important role in the development, progression, and metastasis of cancer, and the extremely crucial feature is hypoxic and acidic. Cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), mesenchymal cells, blood vessels, and interstitial fluid are widely recognized as fundamentally crucial hallmarks for TME. As nanotechnology briskly boomed, the nanoscale drug delivery and imaging platform (NDDIP) emerged and has attracted intensive attention. Based on main characteristics of TME, NDDIP can be classified into pH-sensitive delivery and imaging platforms, enzyme-sensitive delivery and imaging platforms, thermo-sensitive delivery and imaging platforms, redox-sensitive delivery and imaging platforms, and light-sensitive delivery and imaging platforms. Furthermore, imageology is one of the significant procedures for disease detection, image-guided drug delivery, and efficacy assessment, including magnetic resonance imaging (MRI), computed tomography (CT), ultrasound (US), and fluorescence imaging. Therefore, the stimuli-responsive NDDIP will be a versatile and practicable tumor disease diagnostic procedure and efficacy evaluation tool. In this review article, we mainly introduce the characteristics of TME and summarize the progress of multitudinous NDDIP as well as their applications.

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Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery

Cited by 19 publications

References 123 publications

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Biomedical applications of cerium vanadate nanoparticles: a review

Recent Advance in Tumor Microenvironment-Based Stimuli-Responsive Nanoscale Drug Delivery and Imaging Platform

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