Progress and perspectives of cellular pyroptosis in digestive tract tumors

Abstract

Cellular pyroptosis, a novel mode of cell death in recent years, is triggered by cysteine asparaginase. Distinguished from traditional apoptosis and necrosis, this mode of cell death is characterized by the activation of inflammatory vesicles and the release of inflammatory factors. Its unique mechanism and morphological changes have attracted increasing attention regarding their role in the development and progression of gastrointestinal (GI) tumors. This has provided new insights and potential strategies for tumor prevention and treatment. Among these strategies, intervening in the process of cellular pyroptosis has been considered a promising approach to inhibit tumor growth. This review aims to explore the mechanism of cellular pyroptosis, its role in GI tumors, and its potential applications in therapy.