Progress and opportunities in Gellan gum-based materials: A review of preparation, characterization and emerging applications

Gomes, Diana; Batista-Silva, João; Sousa, Ângela; Passarinha, Luís A.

doi:10.1016/j.carbpol.2023.120782

Cited by 24 publications

(10 citation statements)

References 166 publications

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“…Compared with other methods for microsphere fabrication such as single emulsion, phase separation, spray drying, and membrane emulsification, microfluidic technology has many advantages, such as the ability to control microsphere shape and size, high drug loading capacity, and control over the physical and chemical properties of microspheres by manipulating solvent type and polymer concentration. , Hydrogel microspheres hold great promise for tissue repair applications, such as cellular and drug therapy delivery. , In this study, GG was selected to prepare the hydrogel microspheres. GG is a thermosensitive hydrogel scaffold that is a transparent solution at elevated temperatures and a transparent solid at low temperatures. , GG possesses unique physical and chemical properties, such as the ability to form a gel through both thermal and ion-cross-linking mechanisms. , In this study, Ca 2+ was used to induce GG gelation. The gelation mechanism mainly includes the formation of a double-helix region, followed by the formation of a three-dimensional network through the association of cations and hydrogen bonding with water .…”

Section: Discussionmentioning

confidence: 99%

“…GG is a thermosensitive hydrogel scaffold that is a transparent solution at elevated temperatures and a transparent solid at low temperatures. 43,12 GG possesses unique physical and chemical properties, such as the ability to form a gel through both thermal and ion-cross-linking mechanisms. 44,45 In this study, Ca 2+ was used to induce GG gelation.…”

Section: ■ Discussionmentioning

confidence: 99%

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Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

Sun,

Liu,

Guan

et al. 2023

ACS Appl. Nano Mater.

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Spinal cord injury (SCI) has a high disability rate and poor treatment efficacy and severely affects the health and daily life of patients. Improving the local microenvironment after SCI is crucial for restoring the normal physiological function of the spinal cord. In this study, the injectable near-infrared (NIR) photothermal responsive drug-loaded multiwalled carbon nanotubes (DMWCNTs) containing hydrogel microspheres were prepared by microfluidic technology for SCI treatment. Specifically, paclitaxel (PTX) and vascular endothelial growth factor (VEGF) were loaded into dopamine-modified DMWCNTs, which were then further compounded into gellan gum (GG) by using microfluidic technology to obtain [PTX/VEGF]@DMWCNTs/GG microspheres. The physicochemical properties of the microspheres were characterized using various methods, including transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, optical microscopy, and scanning electron microscopy (SEM). Results showed that microspheres with good injectability and controllable drug release were successfully prepared by using microfluidic technology. The presence of MWCNTs endowed the microspheres with photothermal responsiveness, which led to more drug release under NIR irradiation. The cytotoxicity test results showed that the microspheres had no obvious cytotoxicity and the drug-loaded MWCNTs containing hydrogel microspheres could promote the differentiation of neural stem cells (NSCs). Immunofluorescence results in rats with hemisectioned SCI showed that the microspheres promoted the differentiation of NSCs and the growth of neurons and inhibited the formation of astrocytes and glial scars at the lesion site. In conclusion, the injectable near-infrared photothermal responsive drug-loaded multiwalled carbon nanotube hydrogel microspheres prepared in this study exhibit a promoting effect on SCI repair and provide a strategy for developing transplantation materials for SCI treatment.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

Sun,

Liu,

Guan

et al. 2023

ACS Appl. Nano Mater.

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“…In their native state, some acetate residues can be located on the periphery of the double helix [68,[142][143][144].…”

Section: Bacterial Polysaccharides 241 Gellan Gummentioning

confidence: 99%

Diversity of Bioinspired Hydrogels: From Structure to Applications

Lupu¹,

Grădinaru²,

Gradinaru

et al. 2023

Gels

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Hydrogels are three-dimensional networks with a variety of structures and functions that have a remarkable ability to absorb huge amounts of water or biological fluids. They can incorporate active compounds and release them in a controlled manner. Hydrogels can also be designed to be sensitive to external stimuli: temperature, pH, ionic strength, electrical or magnetic stimuli, specific molecules, etc. Alternative methods for the development of various hydrogels have been outlined in the literature over time. Some hydrogels are toxic and therefore are avoided when obtaining biomaterials, pharmaceuticals, or therapeutic products. Nature is a permanent source of inspiration for new structures and new functionalities of more and more competitive materials. Natural compounds present a series of physico-chemical and biological characteristics suitable for biomaterials, such as biocompatibility, antimicrobial properties, biodegradability, and nontoxicity. Thus, they can generate microenvironments comparable to the intracellular or extracellular matrices in the human body. This paper discusses the main advantages of the presence of biomolecules (polysaccharides, proteins, and polypeptides) in hydrogels. Structural aspects induced by natural compounds and their specific properties are emphasized. The most suitable applications will be highlighted, including drug delivery, self-healing materials for regenerative medicine, cell culture, wound dressings, 3D bioprinting, foods, etc.

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“…[ [354][355][356] in the early stages of therapy (Figure 23Biii). Furthermore, TGNPs improve tear production and reduce eye inflammation, indicating their safety and efficacy for treating dry eye disease (DED).…”

Section: Ggmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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Progress and opportunities in Gellan gum-based materials: A review of preparation, characterization and emerging applications

Cited by 24 publications

References 166 publications

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

Diversity of Bioinspired Hydrogels: From Structure to Applications

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

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