Progress and Clinical Applications in Proteomics

Using proteomic and genomic methods to understand JDM

“…Proteomic techniques make it possible to identify specific proteins, modification of proteins, and protein expression levels 32,33) . Proteomic techniques may also be helpful for analyzing the differences in time-course, such as between pre-and post-treatment patients.…”

“…In many ways, the field of genomics as applied to JDM is still in its infancy. For example, while we have some understanding of the genetic contribution to JDM 32) , these studies have been largely undertaken using "candidate gene" approaches. For example, increased risk for JDM has been reported in individuals carrying an HLA B8-DR3 haplotype 36) .…”