Progress and challenges of lyotropic liquid crystalline nanoparticles for innovative therapies

An intelligent phase transformation system based on lyotropic liquid crystals for sequential biomolecule delivery to enhance bone regeneration

“…SAXS is considered the “gold standard” for characterizing the internal symmetry of the LCFS. 34 It was employed to further confirm the internal structure of the LCFS. 35 As shown in the SAXS spectra (Fig.…”

Liquid Crystals as a Vehicle for Croton tiglium L. Oil for Deep Chemical Peel Formulations

“…This study was designed to propose the development of an LC system for the delivery of CO to be used as a new formulation for deep chemical peels, replacing the extemporaneous formulations used in dermatological clinics. It is because LC systems have the potential to protect loaded substances from degradation and have been shown to effectively deliver various active compounds through the stratum corneum [12,14].…”

“…They are notable for their ability to self-organize symmetrically in two-and three-dimensional systems, containing hydro and lipophilic molecules of different sizes. Most of these LC systems are modulated to exhibit different phases to be applied for various purposes, including drug delivery and vaccine platforms, by manipulating their internal structures to acquire different conformations and properties to be administered through several routes [13,14]. LC systems can disrupt biological barriers and overcome, for example, the Brazilian Archives of Biology and Technology.…”

“…Vol.66(spe): e23230034, 2023 www.scielo.br/babt skin and mucosa, due to enhanced retention and permeation effects. This mechanism involves temporary disorganization of these barriers, with the creation of holes through which the encapsulated substances can penetrate freely into deeper layers [14].…”

Development of Liposomal and Liquid Crystalline Lipidic Nanoparticles with Non-Ionic Surfactants for Quercetin Incorporation

“…These nanoparticles can encapsulate drugs within their organized structures and possess a unique nanoscale ordering. Among their advantages, they present high drug loading, enhanced stability, tunable drug release profile based on their internal nanostructures, and enhanced permeability through the biological barriers [ 4 ].…”