Programs for action in superior parietal cortex: A triple-pulse TMS investigation

Striemer, Christopher L.; Chouinard, Philippe A.; Goodale, Melvyn A.

doi:10.1016/j.neuropsychologia.2011.04.015

Cited by 35 publications

(34 citation statements)

References 59 publications

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“…Our previous and present results are in agreement with literature (e.g., Kastner et al, 1998; Fattori et al, 2001, 2005; Andersen and Buneo, 2002; Calton et al, 2002; Snyder et al, 2006; Trillenberg et al, 2007; Ciavarro and Ambrosini, 2011; Striemer et al, 2011) supporting a role for SPL in preparation of reaching (Goodale and Milner, 2004; Buneo and Andersen, 2006). In particular, Beurze et al (2010) found parieto-occipital activations related with foveal vision comparable with our results.…”

Section: Discussionsupporting

confidence: 93%

Transcranial magnetic stimulation and preparation of visually-guided reaching movements

Busan¹,

Zanon²,

Vinciati³

et al. 2012

Front. Neuroeng.

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To better define the neural networks related to preparation of reaching, we applied transcranial magnetic stimulation (TMS) to the lateral parietal and frontal cortex. TMS did not evoke effects closely related to preparation of reaching, suggesting that neural networks already identified by our group are not larger than previously thought. We also replicated previous TMS/EEG data by applying TMS to the parietal cortex: new analyses were performed to better support reliability of already reported findings (Zanon et al., 2010; Brain Topography 22, 307–317). We showed the existence of neural circuits ranging from posterior to frontal regions of the brain after the stimulation of parietal cortex, supporting the idea of strong connections among these areas and suggesting their possible temporal dynamic. Connection with ventral stream was confirmed. The present work helps to define those areas which are involved in preparation of natural reaching in humans. They correspond to parieto-occipital, parietal and premotor medial regions of the left hemisphere, i.e., the contralateral one with respect to the moving hand, as suggested by previous studies. Behavioral data support the existence of a discrete stream involved in reaching. Besides the serial flow of activation from posterior to anterior direction, a parallel elaboration of information among parietal and premotor areas seems also to exist. Present cortico-cortical interactions (TMS/EEG experiment) show propagation of activity to frontal, temporal, parietal and more posterior regions, exhibiting distributed communication among various areas in the brain. The neural system highlighted by TMS/EEG experiments is wider with respect to the one disclosed by the TMS behavioral approach. Further studies are needed to unravel this paucity of overlap. Moreover, the understanding of these mechanisms is crucial for the comprehension of response inhibition and changes in prepared actions, which are common behaviors in everyday life.

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Section: Discussionsupporting

confidence: 93%

Transcranial magnetic stimulation and preparation of visually-guided reaching movements

Busan¹,

Zanon²,

Vinciati³

et al. 2012

Front. Neuroeng.

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“…Other studies administering TMS over the mIPS to study reaching related processes have applied TMS during the planning phase, before the actual movement started (Busan et al, 2009(Busan et al, , 2012Davare et al, 2012;Vesia and Crawford, 2012;Vesia et al, 2006Vesia et al, , 2008Vesia et al, , 2010. The only exception is a study by Striemer et al (2011). There, the authors contrasted a) the contribution of two sites (subsumed as superior parietal lobe (SPL), corresponding roughly to our anterior and posterior mIPS sites) to the planning vs. the execution phase of a proprioception-only reaching movement, and b) the contribution of the inferior parietal lobe vs. the SPL for reach planning and execution.…”

Section: Discussionmentioning

confidence: 99%

“…Behavioral deficits after administering TMS demonstrate a causal contribution of the stimulated cortical area to the correction process. In order to enhance the spatial resolution of TMS, we tested a whole grid of TMS stimulation sites (Busan et al, 2009(Busan et al, , 2012Reichenbach et al, 2011;Striemer et al, 2011) instead of only stimulating one likely candidate area and an unrelated control site.…”

Section: Introductionmentioning

confidence: 99%

A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements

et al. 2014

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Seemingly effortless, we adjust our movements to continuously changing environments. After initiation of a goal-directed movement, the motor command is under constant control of sensory feedback loops. The main sensory signals contributing to movement control are vision and proprioception. Recent neuroimaging studies have focused mainly on identifying the parts of the posterior parietal cortex (PPC) that contribute to visually guided movements. We used event-related TMS and force perturbations of the reaching hand to test whether the same sub-regions of the left PPC contribute to the processing of proprioceptive-only and of multi-sensory information about hand position when reaching for a visual target. TMS over two distinct stimulation sites elicited differential effects: TMS applied over the posterior part of the medial intraparietal sulcus (mIPS) compromised reaching accuracy when proprioception was the only sensory information available for correcting the reaching error. When visual feedback of the hand was available, TMS over the anterior intraparietal sulcus (aIPS) prolonged reaching time. Our results show for the first time the causal involvement of the posterior mIPS in processing proprioceptive feedback for online reaching control, and demonstrate that distinct cortical areas process proprioceptive-only and multi-sensory information for fast feedback corrections.

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“…The SPL is known to be involved in the on-line control and programming of reach movements to target locations in space (e.g., Striemer, Chouinard, & Goodale, 2011; Glover, 2004) and in the control of visual spatial attention, particularly right SPL (e.g., Molenberghs, Mesulam, Peeters, & Vandenberghe, 2007; Corbetta, Shulman, Miezin, & Petersen, 1995). To accurately express the location of a figure object, such as the clock in Figure 1A, signers must attend to the spatial location of the object in the scene, transform this visual representation into a body-centered reference frame, and reach toward the target location with respect to the nondominant hand, which depicts the (non-changing) location of the ground object (the table).…”

Section: Discussionmentioning

confidence: 99%

The Biology of Linguistic Expression Impacts Neural Correlates for Spatial Language

Emmorey

McCullough

Mehta

et al. 2013

Journal of Cognitive Neuroscience

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Biological differences between signed and spoken languages may be most evident in the expression of spatial information. PET was used to investigate the neural substrates supporting the production of spatial language in American Sign Language as expressed by classifier constructions, in which handshape indicates object type and the location/motion of the hand iconically depicts the location/motion of a referent object. Deaf native signers performed a picture description task in which they overtly named objects or produced classifier constructions that varied in location, motion, or object type. In contrast to the expression of location and motion, the production of both lexical signs and object type classifier morphemes engaged left inferior frontal cortex and left inferior temporal cortex, supporting the hypothesis that unlike the location and motion components of a classifier construction, classifier handshapes are categorical morphemes that are retrieved via left hemisphere language regions. In addition, lexical signs engaged the anterior temporal lobes to a greater extent than classifier constructions, which we suggest reflects increased semantic processing required to name individual objects compared with simply indicating the type of object. Both location and motion classifier constructions engaged bilateral superior parietal cortex, with some evidence that the expression of static locations differentially engaged the left intraparietal sulcus. We argue that bilateral parietal activation reflects the biological underpinnings of sign language. To express spatial information, signers must transform visual–spatial representations into a body-centered reference frame and reach toward target locations within signing space.

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Programs for action in superior parietal cortex: A triple-pulse TMS investigation

Cited by 35 publications

References 59 publications

Transcranial magnetic stimulation and preparation of visually-guided reaching movements

Transcranial magnetic stimulation and preparation of visually-guided reaching movements

A key region in the human parietal cortex for processing proprioceptive hand feedback during reaching movements

The Biology of Linguistic Expression Impacts Neural Correlates for Spatial Language

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