Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity

Zouikr, Ihssane; Ahmed, Abdulrzag F; Horvat, Jay C.; Beagley, Kenneth W.; Clifton, Vicki L.; Ray, Allyson; Thorne, Rick F.; Jarnicki, Andrew G.; Hansbro, Philip M.; Hodgson, Deborah M.

doi:10.1016/j.bbi.2014.10.014

Cited by 19 publications

(27 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of studies from our laboratory have indicated that dual exposure of LPS during P3 and 5 in rats produced long-term alterations in inflammatory pain responses later in life. Neonatal LPS administration evoked increased formalin-induced behavioral responses (i.e., flinching and licking) in P13, 22, and adult rats (4, 68, 168). The LPS-induced hyperalgesia observed in P22 rats coincided with altered HPA axis activity, as indicated by increased circulating corticosterone and decreased GR hypothalamic mRNA 1 h postformalin injection, as well as altered immune responses following formalin injection as indicated by increased mast cell degranulation and increased circulating IL-1β (4, 68).…”

Section: Lps As An Experiemental Immunological Stressormentioning

confidence: 97%

“…Neonatal LPS administration evoked increased formalin-induced behavioral responses (i.e., flinching and licking) in P13, 22, and adult rats (4, 68, 168). The LPS-induced hyperalgesia observed in P22 rats coincided with altered HPA axis activity, as indicated by increased circulating corticosterone and decreased GR hypothalamic mRNA 1 h postformalin injection, as well as altered immune responses following formalin injection as indicated by increased mast cell degranulation and increased circulating IL-1β (4, 68). Moreover, the LPS-induced hyperalgesia in preadolescent rats was accompanied by altered spinal dorsal horn (SDH) intrinsic properties, as well as decreased neuronal activity (i.e., Fos expression) in the PAG (68, 168).…”

Section: Lps As An Experiemental Immunological Stressormentioning

confidence: 97%

“…Excessive stress that may challenge or perturb the neuroendocrine system when it is still developing could potentially have far-reaching consequences. This way, early-life stress may alter pain, neuroimmune, and neuroendocrine responses for life (4, 65–69). …”

Section: Ontogeny Of the Hpa Axis During The Perinatal Periodmentioning

confidence: 99%

“…LPS-treated adult rats exhibited hyperalgesia that coincided with central neuroimmune changes, as indicated by increased IL-1β in the hippocampus 1 h postformalin injection. No differences were observed in peripheral IL-1β release or mast cell degranulation (4). Although we reported enhanced hippocampal ILβ in LPS-treated adult rats, we do not know which immune cell releases this pro-inflammatory cytokine following neonatal immune challenge and subsequent inflammatory challenge.…”

Section: Lps As An Experiemental Immunological Stressormentioning

confidence: 99%

“…We have previously shown that rats exposed to LPS during the neonatal period displayed increased circulating IL-1β at P22 in response to formalin injection (4). Adult rats previously subjected to neonatal immune challenge also displayed enhanced hippocampal IL-1β that coincides with the LPS-induced hyperalgesia at this age (4). The source of this hippocampal IL-1β is not known, but it is highly probable that it is originating from astrocytes or microglial cells within the hippocampus.…”

Section: The Neuroimmune Interface In Pain In the Adult Organismmentioning

confidence: 99%

See 4 more Smart Citations

Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions

Zouikr

Karshikoff

2017

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

Chronic pain is a debilitating condition that still is challenging both clinicians and researchers. Despite intense research, it is still not clear why some individuals develop chronic pain while others do not or how to heal this disease. In this review, we argue for a multisystem approach to understand chronic pain. Pain is not only to be viewed simply as a result of aberrant neuronal activity but also as a result of adverse early-life experiences that impact an individual’s endocrine, immune, and nervous systems and changes which in turn program the pain system. First, we give an overview of the ontogeny of the central nervous system, endocrine, and immune systems and their windows of vulnerability. Thereafter, we summarize human and animal findings from our laboratories and others that point to an important role of the endocrine and immune systems in modulating pain sensitivity. Taking “early-life history” into account, together with the past and current immunological and endocrine status of chronic pain patients, is a necessary step to understand chronic pain pathophysiology and assist clinicians in tailoring the best therapeutic approach.

show abstract