Programming Merino lambs by early feed restriction reduces growth rates and increases fat accretion during the fattening period with no effect on meat quality traits

Santos, Alba; Giráldez, Francisco Javier; Mateo, Javier; Frutos, Javier; Andrés, Sonia

doi:10.1016/j.meatsci.2017.08.007

Cited by 26 publications

(27 citation statements)

References 24 publications

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“…In agreement with this idea, the selenium-binding protein, which may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation, was also increased in the liver of RES lambs, likely to use amino acids as an energy source. This situation, together with reduced fatty acid catabolism, might help explain the reduced performance (in terms of decreased ADG) observed in the RES lambs (Santos et al, 2018).Long-term effects of early feed restriction were also observed in genes involved in glucose metabolism (e.g., galactokinase isoform X1 and retinol binding protein 4 isoform X2). Furthermore, several proteins implicated in protein folding (e.g., protein disulfide-isomerases and endoplasmic reticulum protein 29) were differentially accumulated in both experimental groups.…”

Section: Discussionmentioning

confidence: 93%

“…However, RES lambs showed more accumulation of fat in several depots including the liver (Table 2) and intramuscular fat (Santos et al, 2018), which might be related to inhibition of β-oxidation (e.g., down accumulation of enoyl-CoA hydratase, mitochondrial isoform X2, in RES lambs), accumulation of upstream metabolites, and hence impaired fatty acid catabolism for energy production (Alexandre et al, 2015;Fu et al, 2017;Santos et al, 2017). In agreement with this hypothesis, liver fat accretion (as occurred in the RES lambs) has also been related to severe impairment of mitochondrial lipid metabolism mainly promoted by a deficiency in adenosine kinase (Boison et al, 2002), an enzyme which was also reduced in the liver of the RES lambs in this study.…”

Section: Discussionmentioning

confidence: 99%

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Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period

Santos

Valdés

Giráldez

et al. 2018

Animal

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The present study was designed to describe the effects of early feed restriction of Merino lambs on feed efficiency during the fattening period by examining ruminal microbiota and fermentation parameters, gastrointestinal morphology, digestibility or liver proteome. In total, 24 male Merino lambs were randomly assigned to two experimental treatments (n=12 per treatment). Lambs of the first group (ad libitum (ADL)) were kept permanently with the dams, whereas the other 12 lambs (restricted (RES)) were milk restricted. When lambs reached a live BW (LBW) of 15 kg, all the animals were offered the same complete pelleted diet (35 g dry matter/kg LBW per day) until slaughter at a LBW of 27 kg. The RES lambs showed poorer feed efficiency during the fattening period when compared with the ADL group (feed to gain ratio, 3.69 v. 3.05, P<0.001). No differences were observed in ruminal microbiota, fermentation parameters or apparent digestibility. However, the proportion of the small intestine and the length of ileal villi were reduced in the RES lambs. In total, 26 spots/proteins were identified in the liver proteomic profile, with significant differences (P<0.05) between experimental treatments, suggesting a higher catabolism of proteins and a reduction in β-oxidation of fatty acids in RES lambs when compared with the ADL animals. In conclusion, early feed restriction of Merino lambs during the suckling period promotes long-term effects on the small intestine and the proteomic profile of the liver, which may influence the metabolic use of nutrients, thus negatively affecting feed efficiency during the fattening phase.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period

Santos

Valdés

Giráldez

et al. 2018

Animal

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“…One of the main criteria for meat quality is the ultimate pH of the muscles, determined by glycogen depletion and postmortem accumulation of lactic acid [20]. The processes occurring in meat postmortem are interrelated.…”

Section: Postmortem Changes In Meatmentioning

confidence: 99%

Sheep welfare during transport and slaughter in Bulgaria – Impact of welfare on slaughter carcass and meat quality: a review

Ivanov¹

2020

Turk J Vet Anim Sci

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The present work aimed to review the state of sheep welfare in Bulgaria during transportation and slaughter and to evaluate its relationship with slaughter carcass and meat quality. Over the last few years, animal welfare has become increasingly important. Normative documents related to welfare during rearing, transport, and slaughter of animals have been developed and promulgated. A major percentage of these animals are reared for meat production, but attempts to minimize stress and pain during transport and slaughter should be made. Stress reduction and pain control improve animal welfare and also impact carcass and meat quality. This overview demonstrates that improper preslaughter handling deteriorates meat quality and increases stress levels in animals. Consumers are increasingly concerned about meat quality and are even ready to pay more to purchase products of higher quality. One of the main ways for improvement of meat quality is to comply with animal welfare standards. This review focuses on some EU countries such as Bulgaria, taking interest in proper preslaughter handling of sheep due to its beneficial effects on meat and carcass qualities. In addition, this review highlights the factors to consider in sheep handling and their effect on meat and carcass quality.

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“…Lymphocyte counts measured by flow cytometry in peripheral blood, ruminal parameters, and immunoglobulin A (IgA) concentration in serum and ruminal mucosa of fattening lambs being fed ad libitum (ADL) or restricted (RES) diets during the suckling period. 16.9 17.0 1.4 0.957 TLR 10 14.0 13.9 1.3 0.938 1 Cq, quantification cycle. ∆Cq = Cq (cytokines or TLRs) − Cq (β-actin).…”

Section: Immunological Parametersmentioning

confidence: 99%

“…ROM, reactive oxygen metabolites 9. FRAP, ferric reducing ability of plasma 10. SOD, superoxide dismutase 11.…”

mentioning

confidence: 99%

Efecto de la alimentación en la fase de lactancia sobre la eficiencia de utilización del alimento en el período posdestete y su relación con la microbiota del tracto digestivo, el estatus oxidativo e inmunológico en el ganado ovino = Effects of early feed restriction during the post-weaning period on feed efficiency, gastrointestinal microbiota, anti-oxidant status and immunity parameters of lambs

Vidal¹,

de²

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lower gain:feed ratio (0.320 vs. 0.261, P < 0.001) was observed for the RES group. Additionally, an increment of Prevotella sp. was detected in the colonic epimural bacterial community of RES (P = 0.052), whereas Proteobacteria was decreased (P < 0.05). However, the colonic gene expression of toll-like receptors (ΔCq), immunohistochemistry parameters (counts of lymphocytes T, B) and IgA levels (pg IgA/µg total protein) were not modified. In conclusion, the level of nutrition during the suckling phase promoted changes in feed efficiency traits and colonic epimural bacterial community that were not related to the immune response at this level.

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Programming Merino lambs by early feed restriction reduces growth rates and increases fat accretion during the fattening period with no effect on meat quality traits

Cited by 26 publications

References 24 publications

Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period

Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period

Sheep welfare during transport and slaughter in Bulgaria – Impact of welfare on slaughter carcass and meat quality: a review

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