Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Radzki, Radosław P.; Bieńko, Marek; Wolski, Dariusz; Ostapiuk, Monika; Manastyrska, Malgorzata; Kimicka, Aleksandra; Wolska, Joanna

doi:10.3390/ani11020424

Cited by 4 publications

(11 citation statements)

References 45 publications

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“…Indeed, that parental obesity has a programming effect on bone metabolism has been established. We demonstrated this in our earlier work, revealing that the offspring from obese parents are characterized by more intensive bone tissue formation, which results in stronger tissue mineralization and greater mechanical strength on the day of weaning (21 days of life) (Radzki et al, 2021). Therefore, the importance of nutrition during this period is not only reduced to its nutritional values, from which the body draws the necessary ingredients needed for proper growth and development, but also to its short-and long-term impact on health after growth (Dearden et al, 2018).…”

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confidence: 58%

The programming effect of parenteral obesity on the structural and mechanical properties of femora in female rats fed a varied calorie diet during puberty

Radzki

Bieńko

Wolski

2022

Animal Physiology Nutrition

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The study was aimed to ascertain whether continuation or change in the offspring of the diet consumed by the parents modulates, in later life, the previously programmed bone metabolism. We used adult Wistar rats (16 males; 32 females), divided into groups that were fed either a standard (diet S) or a high‐energy (diet F). After 90 days of obesity induction, the rats were submitted to obtain female offspring from parents S and F. The offspring stayed with their mothers until 21 days of age (weaning day). Our previous studies have proved the programming effects of parental obesity on the skeletal system of their offspring at the age of 21 days. Weaned female offspring were divided into groups: S/S‐parents and offspring fed the S diet; S/F‐parents fed the S diet and offspring fed the F diet; F/S‐parents fed the diet F and offspring with the diet S; F/F‐parents and offspring fed the F diet (F/F). After sacrifice, isolated femurs were assessed by peripheral quantitative computed tomography and by a three‐point bending test. The bones were examined at 49 and 90 days of life. We found that nutritional programming has a significant influence on the development and metabolism of the skeletal system in females during growth and maturity. Moreover, the modification of nutrition alters the metabolism of bone tissue, and the osteotropic effects vary depending on the nature of the change, as well as the stage of development. Reducing the caloric content of the diet inhibits the mineralization and decreases the mechanical strength of the bones while increasing the caloric content of the diet has a beneficial osteotropic effect.

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confidence: 58%

The programming effect of parenteral obesity on the structural and mechanical properties of femora in female rats fed a varied calorie diet during puberty

Radzki

Bieńko

Wolski

2022

Animal Physiology Nutrition

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“…For example, having the same males equally represented in both pregnancy groups, aided in controlling for the influence of paternal genetics. This is important as previous research has demonstrated that the paternal genetics can influence the amount of mineral accrual in utero making it an important aspect to be controlled for ( 46 , 47 ). Furthermore, every dam in each group was mated with a different male reducing the genetic contribution that any one male may have within a group to give a more diverse and realistic group of litters.…”

Section: Resultsmentioning

confidence: 99%

Pregnancy and Lactation in Sprague-Dawley Rats Result in Permanent Reductions of Tibia Trabecular Bone Mineral Density and Structure but Consumption of Red Rooibos Herbal Tea Supports the Partial Recovery

2021

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During pregnancy and lactation, maternal bone mineral density (BMD) is reduced as calcium is mobilized to support offspring bone development. In humans, BMD returns to pre-pregnancy levels shortly after delivery, shifting from a high rate of bone resorption during pregnancy and lactation, into a rapid phase of bone formation post-lactation. This rapid change in bone turnover may provide an opportunity to stimulate a greater gain in BMD and stronger trabecular and cortical structure than present pre-pregnancy. Providing polyphenols present in red rooibos herbal tea may promote such an effect. In vitro, red rooibos polyphenols stimulate osteoblast activity, reduce osteoclastic resorption, and increase mineral production. The study objective was to determine if consuming red rooibos from pre-pregnancy through to 4 months post-lactation resulted in a higher BMD and improved trabecular and cortical bone structure in a commonly used rat model. Female Sprague-Dawley rats (n = 42) were randomized to one of the following groups: PREG TEA (pregnant, received supplemental level of red rooibos in water: ~2.6 g /kg body weight/day in water), PREG WATER (pregnant, received water), or NONPREG CON (age-matched, non-pregnant control, received water) from 2 weeks pre-pregnancy (age 8 weeks) through to 4 months post-lactation. Rats were fed AIN-93G (pre-pregnancy through to the end of lactation) and AIN-93M (post-lactation onwards). BMD and trabecular structure (bone volume fraction, trabecular number, trabecular separation) were improved (p < 0.05) by 1- or 2-months post-lactation when comparing PREG TEA to PREG CON, though neither group recovered to the level of NONPREG CON. Cortical outcomes (cortical area fraction, cortical thickness, tissue mineral density) for PREG TEA and PREG CON were reduced (p < 0.05) following lactation but returned to the level of NONPREG CON by 2-months post-lactation, with the exception of cortical thickness. The lack of recovery of BMD and key outcomes of trabecular bone structure was unexpected. While consumption of red rooibos did not result in stronger bone post-lactation, red rooibos did support the partial recovery of trabecular BMD and bone structure following pregnancy and lactation. The findings also provide insight into the timing and dose of polyphenols to study in future interventions.

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“…Our previous studies have shown that parental obesity has a programming influence on skeletal metabolic processes in the offspring [ 14 ]. We also demonstrated that, on the day of weaning, the tibia of the female and male offspring, coming from obese parent, is characterized by stronger growth and more intense mineralization and, thus, greater mechanical endurance.…”

Section: Discussionmentioning

confidence: 99%

“…Bone samples were analyzed using a pQCT Stratec XCT Research SA Plus under control of Stratec software, version 6.20 C (Stratec Medizintechnik GmbH, Pforzheim, Germany). The trabecular and cortical compartments of isolated femora were measured in the distal metaphysis and middle of the shaft of column, respectively, as described previously [ 14 , 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

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Osteotropic Effect of Parenteral Obesity in Programmed Male Rats Fed a Calorically Differentiated Diet during Growth and Development

Radzki

Bieńko

Wolski

et al. 2022

Animals

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The experiment was undertaken to assess whether the continuation or change of the parents’ diet affects the previously programmed bone metabolism of the male offspring during its growth and development. A total of 16 male and 32 female Wistar rats were divided into groups and fed a standard (diet S) or high-energy (diet F). After the induction of obesity, the rats from groups S and F, as the parent generation, were used to obtain male offspring, which were kept with their mothers until the weaning day (21 days of age). In our earlier study, we documented the programming effects of the diet used in parents on the skeletal system of offspring measured on the weaning day. Weaned male offspring constitute one control group—parents and offspring fed the S diet. There were three experimental groups, where: parents received diet S and offspring were fed with the F diet; parents were treated with the diet F, while offspring received the S diet; and parents and offspring were fed with the diet F. The analyses were performed at 49 and 90 days of life. After sacrifice, cleaned-off soft tissue femora were assessed using peripheral quantitative computed tomography (pQCT), dual X-ray absorptiometry (DXA), and a three-point bending test. We observed that changing and continuation of nutrition, applied previously in parents, significantly influenced the metabolism of the bone tissue in male offspring, and the osteotropic effects differed, depending on the character of the nutrition modification and age. Additionally, an important conclusion of our study, regarding the previous, is that nutrition modification, affecting the metabolism of bone tissue, also depends on the sex.

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Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Cited by 4 publications

References 45 publications

The programming effect of parenteral obesity on the structural and mechanical properties of femora in female rats fed a varied calorie diet during puberty

The programming effect of parenteral obesity on the structural and mechanical properties of femora in female rats fed a varied calorie diet during puberty

Pregnancy and Lactation in Sprague-Dawley Rats Result in Permanent Reductions of Tibia Trabecular Bone Mineral Density and Structure but Consumption of Red Rooibos Herbal Tea Supports the Partial Recovery

Osteotropic Effect of Parenteral Obesity in Programmed Male Rats Fed a Calorically Differentiated Diet during Growth and Development

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