Programming and differentiation of rat liver enzymes

Gustafsson, Jan Åke; Eneroth, P.; Pousette, Åake; Skett, Paul; Sonnenschhn, Carlos; Stenberg, Åke; Åhlén, Agneta

doi:10.1016/0022-4731(77)90245-x

Cited by 54 publications

(6 citation statements)

References 58 publications

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“…This conclusion is compatible with the fact that the concentration of gp70 in sera is generally 20-100% higher in male mice than females (11,12,17). The liver is a known source of several proteins whose serum concentrations are associated markedly with the host's sex depending on androgenic hormones (38).…”

Section: Discussionsupporting

confidence: 69%

Murine serum glycoprotein gp70 behaves as an acute phase reactant.

Hara¹,

Izui²,

Dixon³

1982

The Journal of Experimental Medicine

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A single intraperitoneal injection of bacterial lipopolysaccharide (LPS) or its lipid A component induced high levels of glycoprotein, gp70, in sera of several strains of mice within 24 h. This serum gp70 response induced by LPS was independent of the activation of B cells and the presence of T cells. However, serological and immunohistochemical studies demonstrated the production of gp70 by hepatic parenchymal cells and its subsequent release into the circulating blood. The expression of gp70 in the serum was enhanced not only by LPS but also other inducers of acute phase reactants (APR) such as turpentine oil or polyriboinosinic-polyribocytidylic acid. Further, the serum gp70 response was kinetically identical to those of APR. These results strongly suggest that (a) the liver may be the major source for serum gp70, (b) serum gp70 behaves like an APR, (c) its expression may be controlled by a mechanism similar to that for other APR, and (d) this glycoprotein apparently behaves as a normal host constituent and not a product of a viral genome.

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Section: Discussionsupporting

confidence: 69%

Murine serum glycoprotein gp70 behaves as an acute phase reactant.

Hara¹,

Izui²,

Dixon³

1982

The Journal of Experimental Medicine

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“…The mechanisms underlying the latter differences have yet to be determined. However, steroid metabolism by the liver is subject to hormonal imprinting (Gustafsson et al 1977), which may explain differences in response between males and females of the same strain.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Bisphenol A Exposure Increases Estrogen Sensitivity of the Mammary Gland in Diverse Mouse Strains

Wadia

Vandenberg

Schaeberle

et al. 2007

Environ Health Perspect

107

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BackgroundStudies of low-dose effects of xenoestrogens have yielded conflicting results that may be attributed to differences in estrogen sensitivity between the rodent strains examined. Perinatal exposure of CD-1 mice to low doses of the xenoestrogen bisphenol A (BPA) alters peripubertal mammary gland development. Future studies to assess the role of estrogen receptors as mediators of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. The sensitivity of the C57Bl6 strain to estradiol and BPA is unknown.ObjectivesIn the present study we examined whether the mammary glands of CD-1 and C57Bl6 mice exhibited similar responses to 17β-estradiol (E2) and whether perinatal exposure to BPA equally enhanced sensitivity of the mammary glands to E2 at puberty.MethodsImmature mice were ovariectomized and treated for 10 days with one of eight doses of E2. Morphological mammary gland parameters were examined to identify doses producing half-maximal effects. Mice were exposed perinatally to 0 or 250 ng BPA/kg body weight (bw)/day from gestational day 8 until postnatal day (PND) 2. On PND25, female offspring were ovariectomized and given an estrogen challenge of 0, 0.5, or 1 μg E2/kg bw/day for 10 days. Morphometric parameters of the mammary gland were compared between strains.ResultsBoth strains exhibited similar responses to E2. Perinatal BPA exposure altered responses to E2 at puberty for several parameters in both strains, although the effect in CD-1 was slightly more pronounced.ConclusionBoth mouse strains provide adequate models for the study of perinatal exposure to xenoestrogens.

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“…In either event the results of this study indicate production of s-Gxx-gp70 by an organ or tissue that has not yet been serologically identified as Gxx-positive. The liver, as the source of several proteins whose concentration in serum is markedly dependent on sex (16), would from that viewpoint seem a likely source of s-Gxx-gp70, but there has so far been no serological evidence of Gxx-gp70 in this organ.…”

Section: Discussionmentioning

confidence: 99%

Source and hormone-dependence of GLx-gp70 in mouse serum

Obata¹,

Stockert²,

Yamaguchi³

et al. 1978

The Journal of Experimental Medicine

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The gp70 family of glycoproteins is distinguished by the role of these molecules as constituents of C-type viral envelopes and also as Mendelian cellular constituents expressed independently of virus production. The source of G(IX)-gp70 in the serum of 129 strain mice, which are not overt producers of virus, could not be traced to any organ or tissue that is known to be G(IX)-positive by serological tests. Hematopoietic tissues were excluded as source of serum G(IX)-gp70 by tests with reciprocal radiation chimeras made from 129 and 129-G(IX)(-) donors and recipients. Thymus and spleen were excluded because excision of these organs did not affect levels of G(IX)-gp70 in the serum. The serum of young adult 129 males contains roughly four times as much G(IX)-gp70 as adult 129 females and the levels rise in both sexes with increasing age. Castration of 129 males reduced the level of serum G(IX)-gp70 to that of females, and the level was fully restored by testosterone. Thus the epididymis and seminal fluid, though rich in G(IX)-gp70, do not contribute significant amounts of G(IX)-gp70 to the serum. The level of G(IX)-gp70 in the serum of testosterone-treated females, though more than double that of untreated females, did not reach the level of normal males, under the conditions tested. This may signify that G(IX)-gp70 production by males is subject to imprinting by testosterone in early life. Evidently the main source of serum G(IX)-gp70 is a tissue or organ that is common to males and females, is directly or indirectly responsive to testosterone, and has not so far been identified serologically as G(IX)- positive.

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Programming and differentiation of rat liver enzymes

Cited by 54 publications

References 58 publications

Murine serum glycoprotein gp70 behaves as an acute phase reactant.

Murine serum glycoprotein gp70 behaves as an acute phase reactant.

Perinatal Bisphenol A Exposure Increases Estrogen Sensitivity of the Mammary Gland in Diverse Mouse Strains

Source and hormone-dependence of GLx-gp70 in mouse serum

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