Programmed release of hydrogel microspheres via regulating the immune microenvironment to promotes bone repair

Cai, Weiye; Xu, Xiaoping; Jiang, Yingcun; Cheng, Kang; Liu, Fei; Song, Chao; Guo, Daru; Hu, Zhenming; Liu, Zongchao

doi:10.1016/j.mtadv.2023.100381

Cited by 8 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These CRL@BMP-2@MS microspheres were found to regulate acute bone immune myopathies through the early release of Res, while the sustained release of BMP-2 facilitated the programmed synergistic linkage between immunity and osteogenesis, thereby dynamically regulating bone repair. This novel approach offers a promising avenue for further exploration in the repair of large bone defects [ 145 ]. In contrast, Mao et al conducted a study in which they covalently integrated BMP-2 with silver core-embedded mesoporous silica nanoparticles (Ag@MSN) and subsequently encapsulated them within Filipino methacryloyl hydrogel.…”

Section: Bone Repair Hydrogelsmentioning

confidence: 99%

“… Composite schematic diagram of CRL@ BMP-2@MS. Reproduced from ref. [ 145 ]. under Creative Commons Attribution (accessed on 13 December 2023).…”

Section: Figurementioning

confidence: 99%

Section: Growth Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Repair of Infected Bone Defects with Hydrogel Materials

Cao,

Qin,

Duns

et al. 2024

Polymers

View full text Add to dashboard Cite

Infected bone defects represent a common clinical condition involving bone tissue, often necessitating surgical intervention and antibiotic therapy. However, conventional treatment methods face obstacles such as antibiotic resistance and susceptibility to postoperative infections. Hydrogels show great potential for application in the field of tissue engineering due to their advantageous biocompatibility, unique mechanical properties, exceptional processability, and degradability. Recent interest has surged in employing hydrogels as a novel therapeutic intervention for infected bone repair. This article aims to comprehensively review the existing literature on the anti-microbial and osteogenic approaches utilized by hydrogels in repairing infected bones, encompassing their fabrication techniques, biocompatibility, antimicrobial efficacy, and biological activities. Additionally, the potential opportunities and obstacles in their practical implementation will be explored. Lastly, the limitations presently encountered and the prospective avenues for further investigation in the realm of hydrogel materials for the management of infected bone defects will be deliberated. This review provides a theoretical foundation and advanced design strategies for the application of hydrogel materials in the treatment of infected bone defects.

show abstract

Section: Bone Repair Hydrogelsmentioning

confidence: 99%

“… Composite schematic diagram of CRL@ BMP-2@MS. Reproduced from ref. [ 145 ]. under Creative Commons Attribution (accessed on 13 December 2023).…”

Section: Figurementioning

confidence: 99%

Section: Growth Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Repair of Infected Bone Defects with Hydrogel Materials

Cao,

Qin,

Duns

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

“…In this study, the long-range sustained release effect of BMP-2 was achieved by this specific binding site and electrostatic adsorption of heparin and BMP-2 protein. [31] Therefore, the release of BMP-2 in hydrogel microspheres was evaluated. Our ELISA experiments revealed that the release of BMP-2 had a burst release under 9 h ultrasound excitation.…”

Section: Spatiotemporalized Hydrogel Microspheres' Responsiveness To ...mentioning

confidence: 99%

Spatiotemporalized Hydrogel Microspheres Promote Vascularized Osteogenesis via Ultrasound Oxygen Delivery

Chen,

Han,

Cao

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Disturbance of spatiotemporal oxygen balance is the main cause of delayed healing or nonhealing of large bone defects. The accurate administration of oxygen to regulate disruptions in the spatiotemporal oxygen equilibrium during 9 h of hypoxia is imperative for bone tissue regeneration. Herein, oxygen‐loaded nanobubbles prepared by double emulsification are successfully embedded in GelMA/HepMA microsphere macromolecular meshwork by microfluidic techniques, and a spatiotemporalized hydrogel microsphere is constructed by noncovalently binding bone morphogenetic protein 2 (BMP‐2). The spatiotemporalized hydrogel microspheres precisely “remote control” oxygen release by ultrasound in vitro 9 h after bone injury to regulate spatiotemporal oxygen homeostasis disorder, maintain a high level of vascular endothelial growth factor (VEGF) expression, and accelerate bone repair. The spatiotemporalized hydrogel microspheres possess good oxygen‐carrying capacity and ultrasonic responsiveness, and the oxygen concentration increases to 1.63, 1.95, 2.11, and 2.29 times under the ultrasound action at different intensities of 1, 2, 3, and 4 W, respectively, providing the conditions for the precise regulation of spatiotemporal oxygen balance disorder by ultrasound. In the in vitro hypoxia model and in vivo rat femoral defect model, the spatiotemporal hydrogel microspheres show good vascularization and osteogenesis capabilities, which provide a new strategy for the clinical treatment of large bone defects.

show abstract

“…In particular, glucocorticoids (GCs) induced osteonecrosis of the femoral head (GI-ONFH) is closely related to the abnormal local immune response mediated by macrophages, wherein the osteonecrosis area was found to be dominated by M1 macrophages and reduced M2/M1 ratio, resulting in a decrease in the secretion of pro-tissue repair factors such as VEGF, BMP2 and TGF-β by M2, which finally inhibited new bone formation and led to difficulties in osteonecrosis repair [ [3] , [4] , [5] ], and thus regulation of macrophage phenotypic transformation appears to be a promising approach to treat osteonecrosis such as GI-ONFH. Indeed, immune regulation that creates an osteogenic-friendly microenvironment to effectively promote bone repair and regeneration has attracted considerable interest in recent years for constructing bone related biomaterial platforms [ [6] , [7] , [8] , [9] , [10] , [11] , [12] ], such as barrier membranes, scaffold, and hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Immune regulation enhances osteogenesis and angiogenesis using an injectable thiolated hyaluronic acid hydrogel with lithium-doped nano-hydroxyapatite (Li-nHA) delivery for osteonecrosis

Luo,

Yang,

Zhao

et al. 2024

Materials Today Bio

View full text Add to dashboard Cite

Programmed release of hydrogel microspheres via regulating the immune microenvironment to promotes bone repair

Cited by 8 publications

References 52 publications

Repair of Infected Bone Defects with Hydrogel Materials

Repair of Infected Bone Defects with Hydrogel Materials

Spatiotemporalized Hydrogel Microspheres Promote Vascularized Osteogenesis via Ultrasound Oxygen Delivery

Immune regulation enhances osteogenesis and angiogenesis using an injectable thiolated hyaluronic acid hydrogel with lithium-doped nano-hydroxyapatite (Li-nHA) delivery for osteonecrosis

Contact Info

Product

Resources

About