Programmed death-1 (PD-1) polymorphisms in Chinese patients with esophageal cancer

Qiu, Hao; Zheng, Liang; Tang, Weifeng; Yin, Peng; Cheng, Feng; Wang, Lixin

doi:10.1016/j.clinbiochem.2013.12.023

Cited by 37 publications

(36 citation statements)

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“…The etiology of EGJA is very complicated. Accumulating evidences demonstrated that SNPs in some immune response genes might be associated with risk of cancer [6, 26–28]. In consideration of the vital role of PD-1 in tumor immunology, we chose PD-1 rs10204525 T>C, rs2227982 A>G, rs36084323 T>C and rs7421861 A>G polymorphisms to examine their potential roles in EGJA.…”

Section: Discussionmentioning

confidence: 99%

“…Some epidemiological studies focused on the effect of PD-1 rs7421861 A>G locus on the development of multiple cancers; however, the results remained inconsistent. Several case-control reported that PD-1 rs7421861 A>G polymorphism was not associated with cancer risk [19, 27, 28, 30]. However, Ge et al .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, several studies reported there was no significant association between PD-1 rs2227982 A>G polymorphism and cancer (e.g. esophageal squamous cell carcinoma, colorectal cancer, breast cancer and non-small cell lung cancer) [27, 28, 30, 31]. A recent meta-analysis suggested that PD-1 rs2227982 A>G polymorphism might be not associated with the risk of overall cancer.…”

Section: Discussionmentioning

confidence: 99%

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Programmed death-1 polymorphisms is associated with risk of esophagogastric junction adenocarcinoma in the Chinese Han population: A case-control study involving 2,740 subjects

Tang

Chen

et al. 2017

Oncotarget

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Single nucleotide polymorphisms (SNPs) in Programmed cell death 1 (PD-1) gene may contribute to the development of cancer. In this study, we selected PD-1 rs10204525 T>C, rs2227982 A>G, rs36084323 T>C and rs7421861 A>G polymorphisms and designed a hospital-based case-control study to determine the potential relationship between these functional SNPs in PD-1 gene and esophagogastric junction adenocarcinoma (EGJA) risk. A total of 1,063 EGJA patients and 1,677 controls were enrolled from Eastern Chinese Han population. SNPscanTMgenotyping assay was used to analyze the genotyping of PD-1 polymorphisms. We found that PD-1 rs7421861 A>G polymorphism was associated with the development of EGJA. However, PD-1 rs2227982 A>G polymorphism was a protective factor for EGJA. In addition, PD-1 rs36084323 CC homozygote genotype might be associated with a borderline decreased risk of EGJA. In a subgroup analysis, a decreased risk of EGJA in never drinking and never smoking groups was identified. Haplotype comparison analysis suggested that PD-1 Trs10204525Grs2227982C36084323Ars7421861 haplotype significantly decreased the risk of EGJA. However, Trs10204525Grs2227982C36084323Grs7421861 haplotype in PD-1 gene may confer risk to EGJA. In conclusion, our study highlights rs2227982 A>G, rs36084323 T>C and rs7421861 A>G polymorphisms and haplotypes in PD-1 gene, especially within the intron region, are significantly associated with the risk of EGJA. Further case-control studies with larger sample size and detailed gene-environmental data to replicate these findings in different populations are needed to validate our conclusion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Programmed death-1 polymorphisms is associated with risk of esophagogastric junction adenocarcinoma in the Chinese Han population: A case-control study involving 2,740 subjects

Tang

Chen

et al. 2017

Oncotarget

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“…Esophageal squamous cell carcinoma (ESCC), as the major pathological type, has become a major health threat to Chinese [2]. Despite great advance in the treatment strategies, the clinical outcomes of ESCC patients remained unsatisfactory [2, 3]. According to Siegel's cancer statistics, the 5-year survival rate was 49.3% for localized disease and only 2.8% for metastatic disease [4].…”

Section: Introductionmentioning

confidence: 99%

“…According to Siegel's cancer statistics, the 5-year survival rate was 49.3% for localized disease and only 2.8% for metastatic disease [4]. Among the risk factors involving in the prognosis of ESCC patients, the host immune responses, tumor infiltrating immune cells and cytokines, are of great importance [3, 5-7]. The infiltration of IL-17+ cells plays bipolar roles in tumor immunity: tumor protective immunity or pro-tumor immunity [6, 7].…”

Section: Introductionmentioning

confidence: 99%

IL-17A promotes migration and tumor killing capability of B cells in esophageal squamous cell carcinoma

et al. 2016

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We have previously reported that the accumulation of IL-17-producing cells could mediate tumor protective immunity by promoting the migration of NK cells, T cells and dendritic cells in esophageal squamous cell carcinoma (ESCC) patients. However, there were no reports concerning the effect of IL-17A on tumor infiltrating B cells. In this study, we investigated the accumulation of CD20+ B cells in the ESCC tumor nests and further addressed the effect of IL-17A on the migration and cytotoxicity of B cells. There was positive correlation between the levels of CD20+ B cells and IL-17+ cells. IL-17A could promote the ESCC tumor cells to produce more chemokines CCL2, CCL20 and CXCL13, which were associated with the migration of B cells. In addition, IL-17A enhanced the IgG-mediated antibody and complement mediated cytotoxicity of B cells against tumor cells. IL-17A-stimulated B cells gained more effective direct killing capability through enhanced expression of Granzyme B and FasL. The effect of IL-17A on the migration and cytotoxicity of B cells was IL-17A pathway dependent, which could be inhibited by IL-17A inhibitor. This study provides further understanding of the roles of IL-17A in humoral response, which may contribute to the development of novel tumor immunotherapy strategy.

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The association between interleukin‐21 (rs2055979G/T) gene polymorphism and the risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus

Bakr

Awad

Moustafa

et al. 2019

J of Cellular Biochemistry

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Cancer prevalence is critically increasing worldwide; accordingly, improved prediction and therapeutic tools are necessary. Interleukin (IL)‐21 is a potent antitumor cytokine, and the relationship between its gene variations and cancer risk is well established. Nevertheless, so far no study has investigated its role in hepatocellular carcinoma (HCC) progression and metastasis in hepatitis C virus (HCV)‐infected people. Therefore, the present investigation was led on 267 Egyptian participants, involving 177 patients with HCV of which 90 patients had HCC (HCC group), 87 patients without HCC (non‐HCC group), and 90 unrelated healthy controls. The association between rs2221903A/G and rs2055979G/T of the IL‐21 gene and the risk of HCC and metastasis, as well as the clinico‐pathological features, were analyzed. While rs2221903A/G polymorphism was not polymorphic in our cohort, patients carrying the genotype TT and allele T of the rs2055979G/T polymorphism had a significantly lower risk of HCC when comparing with HCC group and healthy controls. Also, participants carrying the aforementioned genotype and allele had a significantly lower risk of metastasis when comparing metastatic group with both nonmetastatic group and control group. The rs2055979G/T polymorphism was not significantly associated with clinico‐pathological features of HCC. This is the first study to report a relationship between an intronic polymorphism in IL‐21 gene and HCC and metastasis risk in the Egyptian people, in addition to identifying a potential new marker for the early detection and treatment of HCC.

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Programmed death-1 (PD-1) polymorphisms in Chinese patients with esophageal cancer

Cited by 37 publications

References 38 publications

Programmed death-1 polymorphisms is associated with risk of esophagogastric junction adenocarcinoma in the Chinese Han population: A case-control study involving 2,740 subjects

Programmed death-1 polymorphisms is associated with risk of esophagogastric junction adenocarcinoma in the Chinese Han population: A case-control study involving 2,740 subjects

IL-17A promotes migration and tumor killing capability of B cells in esophageal squamous cell carcinoma

The association between interleukin‐21 (rs2055979G/T) gene polymorphism and the risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus

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