Programmed Cell Death Initiation and Execution in Budding Yeast

Strich, Randy

doi:10.1534/genetics.115.179150

Cited by 39 publications

(29 citation statements)

References 164 publications

(176 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Active cell death processes are not unique to animals and have been described in plants [19], yeast [20], protozoa [21], and bacteria [22]. In some cases, attempts have been made to relate these events to apoptosis, sometimes implying an evolutionary relationship.…”

Section: Caspases Versus Metacaspases: Non-animal Apoptosis?mentioning

confidence: 99%

Just So Stories about the Evolution of Apoptosis

Green

Fitzgerald

2016

Current Biology

View full text Add to dashboard Cite

Apoptosis is a form of active cell death engaged by developmental cues as well as many different cellular stresses in which the dying cell essentially ‘packages’ itself for removal. The process of apoptotic cell death, as defined at the molecular level, is unique to the Metazoa (animals). Yet active cell death exists in non-animal organisms, and in some cases molecules involved in such death show some sequence similarities to those involved in apoptosis, leading to extensive speculation regarding the evolution of apoptosis. Here, we examine such speculation from the perspective of the functional properties of molecules of the mitochondrial apoptotic cell death pathway. We suggest scenarios for the evolution of one pathway of apoptosis, the mitochondrial pathway, and consider how they might be tested. We conclude with a ‘Just So Story’ of how the mitochondrial pathway of apoptosis might have evolved during eukaryotic evolution.

show abstract

Section: Caspases Versus Metacaspases: Non-animal Apoptosis?mentioning

confidence: 99%

Just So Stories about the Evolution of Apoptosis

Green

Fitzgerald

2016

Current Biology

View full text Add to dashboard Cite

show abstract

“…PCD in yeast displays many of the same cellular landmarks as apoptosis in higher organisms, such as DNA fragmentation, cell surface changes, and involvement of mitochondria and reactive oxygen species (ROS) 9495. For this reason, yeast PCD is often referred to as "yeast apoptosis".…”

Section: Varying Fates Varying Functionsmentioning

confidence: 99%

Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation

Honigberg¹

2016

Microbial Cell

View full text Add to dashboard Cite

Diploid budding yeast (Saccharomyces cerevisiae) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in response to similar environmental cues, are regulated by the same signal transduction pathways, and share many of the same master regulators. I propose that the relationships between fate choice, environmental cues and signaling pathways are not Boolean, but involve graded levels of signals, pathway activation and master-regulator activity. In the absence of large differences between environmental cues, small differences in the concentration of cues may be reinforced by cell-to-cell signals. These signals are particularly essential for fate determination within communities, such as colonies and biofilms, where fate choice varies dramatically from one region of the community to another. The lack of Boolean relationships between cues, signaling pathways, master regulators and cell fates may allow yeast communities to respond appropriately to the wide range of environments they encounter in nature.

show abstract

“…The baker's yeast Saccharomyces cerevisiae, mainly known for its use in different industries and as one of the major eukaryotic models, has proven to be a useful toolbox to study cellular processes such as the cell cycle, cellular energy production, but also PCD (Botstein et al, 1997;Strich, 2015). Due to the high conservation of these cellular processes, yeast can also be used to study human pathologies caused by deviations in cellular regulations.…”

Section: Introductionmentioning

confidence: 99%