Programmed Cell Death and Aging in Drosophila Melanogaster

Grigliatti, Thomas A.

doi:10.1007/978-1-4613-1939-9_14

Cited by 6 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is suggested that the larval phase may simply act as to program the subsequent time of reproductive failure and the onset of the senescent period. No particular mechanism of gene action is indicated or implied, but the activation of the adult stage genes at or before the time of eclosion followed by their environmentally pre-programmed, strain-specific times of inactivation/depletion of gene product would be consistent with Grigliatti's data [23] showing that the product of most adult stage genes is required continuously. It is also consistent with Paigen's data [42] showing the existence of cis-acting regulatory genes that control the temporal activity of associated structural genes.…”

Section: A Possible Modelsupporting

confidence: 62%

“…These are the sex-linked ts accelerated aging mutant uncovered by Grigliatti [23] and our autosoma1 extended longevity strain described here. Both systems produce normal but temporally altered patterns of aging [23] (Figure 1). It is possible that these two systems may act as positive and negative regulators of aging and longevity under normal circumstances.…”

Section: Suggestions For Future Experimentsmentioning

confidence: 93%

“…It also indicated the success of the phenotypic strategy of genetic analyses as discussedabove. In their subsequent investigations, they were able to profitably employ some of the high resolution genetic techniques available in Drosophila [23]. Temperature shift experiments constitute a relatively simple and straightforward means of determining the time of gene action [5 11.…”

Section: Accelerated Agingmentioning

confidence: 99%

See 2 more Smart Citations

Genetic analyses of aging processes inDrosophila

Arking

1988

Experimental Aging Research

View full text Add to dashboard Cite

Genetic investigations into the aging processes of Drosophila have a long history. Much of the earlier work attempted the analysis of longevity in already existing and (usually) short-lived strains and mutants, but was unsuccessful because there was no way of assuring that the genes involved actually affected the normal aging processes. Success was achieved only when procedures were devised to specifically select for mutants and/or strains affecting the normal aging processes. Recent work has shown that the life span may be genetically altered either via an acceleration of the normal aging rate or via the stage-specific lengthening of certain portions of the adult life span. A variety of evidence suggests that aging is best viewed as a genetically determined, environmentally modulated, event dependent process. The evidence underlying these observations is discussed, a possible genetic model is presented and future directions are suggested.

show abstract

Section: A Possible Modelsupporting

confidence: 62%

Section: Suggestions For Future Experimentsmentioning

confidence: 93%

Section: Accelerated Agingmentioning

confidence: 99%

See 1 more Smart Citation

Genetic analyses of aging processes inDrosophila

Arking

1988

Experimental Aging Research

View full text Add to dashboard Cite

show abstract

“…O tempo de vida, de acordo com essa programação, deveria conciliar as necessidades da reprodução e o não sobrecarregamento do meio ambiente com excesso de população, garantindo um quantitativo mínimo de indivíduos para a preservação de cada espécie 7,8 . Miller 9 , nesse sentido, menciona dois grandes métodos de quantificação da esperança de vida das espécies: a estimativa da máxima esperança de vida potencial e da taxa de aumento da mortalidade com o correr dos anos.…”

Section: Teorias Com Base Genéticaunclassified

Teorias biológicas do envelhecimento: do genético ao estocástico

Farinatti

2002

Rev Bras Med Esporte

View full text Add to dashboard Cite

Biological theories of aging: genetic and stochastic approachesThe biological theories of aging analyze the degeneration process of the structure and function of cells and organic INTRODUÇÃOA entrada na velhice depende de vários aspectos que ultrapassam limiares da mera cronologia. Cada indivíduo reage de forma única ao avanço da idade. Como bem afirma Levet-Gautrat 1 , "...não existe uma entrada na velhice e sim entradas diferentes e sucessivas" (p. 5). A velhice é construída paulatinamente, para o que concorrem variá-veis biológicas e sociais, e muitos foram os autores que se preocuparam em explicar sua contribuição. Enquanto alguns estudos se dedicam ao entendimento do declínio das funções biológicas, outros debruçam-se sobre os padrões de comportamento adotados pela pessoa idosa.As teorias biológicas do envelhecimento examinam o assunto sob a ótica do declínio e da degeneração da função RESUMOAs teorias biológicas do envelhecimento examinam o assunto sob a ótica da degeneração da função e estrutura dos sistemas orgânicos e células. De forma geral, podem ser classificadas em duas categorias: as de natureza genéti-co-desenvolvimentista e as de natureza estocástica. As primeiras entendem o envelhecimento no contexto de um continuum controlado geneticamente, enquanto as últimas trabalham com a hipótese de que o processo dependeria, principalmente, do acúmulo de agressões ambientais. Por outro lado, são freqüentes as alusões ao exercício físico como estratégia de intervenção que poderia ter influências positivas no processo de envelhecimento, retardando algumas das disfunções comuns na idade avançada. O presente estudo apresenta os princípios gerais de algumas das correntes teóricas mais aceitas, quais sejam: a) teorias com base genética; b) teorias com base em danos de origem química; c) teorias com base no desequilíbrio gradual; d) teorias com base em restrição calórica. São feitas considerações sobre seus pontos consensuais e duvidosos e, quando possível, analisando a possibilidade de o exercício influenciar em seu desenvolvimento. Conclui-se que as teorias afeitas a ambas as abordagens carecem de comprovação definitiva, existindo dúvidas sobre sua influência e as formas pelas quais interagiriam. Igualmente, considerando a natureza dos processos descritos nas diferentes propostas teóricas, o papel do exercício como estratégia de prevenção do envelhecimento parece, no mínimo, incerto.Palavras-chave: Envelhecimento. Genética. Exercício. Função hormonal. Fatores exógenos.

show abstract

“…Genetic evidence also bears on the question of whether a genetic program underlies aging and senescence. Grigliatti 84 has examined the temperature‐sensitive (ts) periods of a number of ts adult lethal mutants. The duration of the ts periods is believed to measure the time when the particular gene product is required by the organism and thus to generally correspond with the period during which the gene is active.…”

Section: Testing Of Aging Theories: What Do We Know About the Mechanimentioning

confidence: 99%

Review of Genetic Investigations into the Aging Processes of Drosophila

Arking¹,

Dudas²

1989

J American Geriatrics Society

View full text Add to dashboard Cite

The field has progressed to the point where a genetic investigation of the aging processes in Drosophila can be viewed as constituting both a serious and a feasible research program. There now exists at least one single gene mutant which yields an accelerated aging phenotype, at least two single gene null mutants affecting enzymes implicated in regulating the aging process and resulting in premature death, and at least two strains created by artificial selection which produce extended-longevity phenotypes. In addition, genes such as adh have an indirect and interactive effect upon the animal's longevity and might also play an important role in the genetic regulation of this process. Although far from complete, some essential tools are now in place and are being used to answer some of the questions posed by Martin. Of the several theories put forth to explain aging in Drosophila, it appears as if the data best uphold the free radical and the protein synthesis/gene expression theories. It is entirely possible that these two theories are complementary aspects of a broader underlying process. The genetic mechanisms controlling these physiological processes clearly do so in concert with certain environmental factors. The net effect of their interactions may be the decreased synthetic and repair ability of the cell as suggested by Lamb and by Webster. It is probably true that aging and longevity are multicausal phenotypes. Our only hope of understanding such a complex phenotype is to dissect it genetically, one (or a few) genes at a time under rigidly controlled conditions. Thorough genetic description of each system will be the prerequisite to their molecular analysis. This will likely result in multiple explanations, ideally one for each system. Yet these multiple molecular genetic explanations may well enable us to see some commonality underlying the aging process in this organism. The fact that several different lines of evidence appear to be converging on a small number of theoretical explanations is an encouraging sign. We should also be heartened by the extraordinary increase in our knowledge of embryonic development in Drosophila as a result of just such a strategy. And we should not forget that the homeotic mutants which now play such a large role in the deciphering of embryogenesis were once classified as "complex loci" and that the then-accepted explanations gave no hint of the underlying molecular relationships. For now it is fair to conclude that aging in Drosophila may be viewed as a genetically-determined, environmentally-modulated, event-dependent process.(ABSTRACT TRUNCATED AT 400 WORDS)

show abstract

Programmed Cell Death and Aging in Drosophila Melanogaster

Cited by 6 publications

References 8 publications

Genetic analyses of aging processes inDrosophila

Genetic analyses of aging processes inDrosophila

Teorias biológicas do envelhecimento: do genético ao estocástico

Review of Genetic Investigations into the Aging Processes of Drosophila

Contact Info

Product

Resources

About