Programmable Nanoassemblies from Non‐Assembling Homopolymers Using Ad Hoc Electrostatic Interactions

Zhuang, Jiaming; Garzoni, Matteo; Torres, Diego F. Amado; Poe, Ambata; Pavan, Giovanni M.; Thayumanavan, S.

doi:10.1002/anie.201611688

Cited by 21 publications

(15 citation statements)

References 52 publications

(11 reference statements)

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“…By integrating a GSH stimulus‐responsive segment into a nanoparticle system, the release profiles of the drugs can be fine‐tuned. For example, −S−S− linkages are stable in blood plasma, but they are cleaved at elevated redox potentials . In addition, the low pH microenvironment of cancer tissues is typically useful in the development of stimulus‐responsive therapeutic agents .…”

Section: Introductionmentioning

confidence: 99%

pH/Redox‐Triggered Photothermal Treatment for Cancer Therapy Based on a Dual‐Responsive Cationic Polymer Dot

et al. 2018

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In the present study, a pH/redox‐responsive cationic polymer dot (CD) was successfully prepared for a near‐infrared (NIR)‐mediated, simultaneously controllable photothermal temperature guided imaging off/on system to monitor therapeutic delivery. Carbonized disulfide cross‐linked branched polyethyleneimine (bPEI) was conjugated with folic acid (FA) as a targeting moiety and partially formed an ionic complex with anionic indocyanine green (ICG) to afford a bPEI‐based CD (ICG‐CD). This was responsive to mild reductive (glutathione, GSH) and acidic tumor conditions, which enabled the simultaneous biodegradation of those hydrophobic and complex sites. The ICG‐CD internalized readily into the cytoplasm of cancer cells by a FA receptor and cationic‐mediated endocytosis in the off state, whereas if ICG‐CD met intracellular GSH at high concentrations, GSH contributed partially to the recovery of fluorescence and was then internalized into acidic endosomes to induce complete restoration of fluorescence. This tumor‐sensitive degradability of the CD not only facilitated ICG release in the tumor location but also allowed controllable photothermal therapy effects of nanoparticles under NIR irradiation, which resulted in improved cancer therapy. Taken together, the results indicate great potential in tumor targeting, intracellular imaging, and controllable therapeutic delivery through a fluorescence off/on assay under the pH/redox conditions of cancer cells.

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Section: Introductionmentioning

confidence: 99%

pH/Redox‐Triggered Photothermal Treatment for Cancer Therapy Based on a Dual‐Responsive Cationic Polymer Dot

et al. 2018

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“…The newly formed bond can be cleaved, either via reduction or exchange with another thiol. Thayumanavan and co‐workers used this chemistry for the crosslinking and surface modification of several nanostructures . For example, they designed programmable nanoassemblies from nonassembling homopolymers through the introduction of electrostatic interactions.…”

Section: Other Reactions For Particle Functionalizationmentioning

confidence: 99%

“…While this functionalization reaction is reversible, the authors furthermore modified the surface with isothiocyanate bearing rhodamine through reaction with accessible amine groups. With this, the authors presented a synthetic platform that facilitate the generation of programmable nanoassemblies with tunable properties …”

Section: Other Reactions For Particle Functionalizationmentioning

confidence: 99%

“…Thayumanavan and co-workers used this chemistry for the crosslinking and surface modification of several nanostructures. [217][218][219][220][221] For example, they designed programmable nanoassemblies from nonassembling homopolymers through the introduction of electrostatic interactions. Once constructed, the vesicle-like structures were covalently stabilized by self-crosslinking induced by the addition of dithiothreitol (DTT) via dithiol-disulfide exchange reaction of the side chains.…”

Section: Thiol-disulfide Exchange Reactionmentioning

confidence: 99%

“…With this, the authors presented a synthetic platform that facilitate the generation of programmable nanoassemblies with tunable properties. [219] Furthermore, the Thayumanavan group applied the thioldisulfide exchange reaction for postfunctionalization of noncationic RNA-polymer complexes. [222,223] Methylated pyridyl disulfide groups among the polymeric scaffold were the key of this synthetic strategy.…”

Section: Thiol-disulfide Exchange Reactionmentioning

confidence: 99%

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Reactive Precursor Particles as Synthetic Platform for the Generation of Functional Nanoparticles, Nanogels, and Microgels

Gruber

Navarro

Klinger

2019

Adv Materials Inter

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Precise control of the chemical functionality of polymer nanoparticles is a key requirement in tailoring their (dynamic) colloidal properties toward advanced applications. However, current synthetic techniques are still limited in the versatility of chemical design and preparation of such functional colloidal nanomaterials. Two major challenges remain: First, various particle preparation methods are restricted in their functional group tolerance, thus hindering certain combinations of polymer backbones with specific functional groups. Second, the preparation of particles with different functionalities requires the synthesis of different particle batches. But this often results in a simultaneous variation of colloidal features. As a result, the accurate determination of important structure–property relations is still hindered. To address these restrictions, postmodification of preformed reactive particles is gaining more attention. This technique has evolved from polymer synthesis, where postpolymerization functionalization enables the introduction of a plethora of functional groups without changing the degree of polymerization and the molecular weight distribution. Similarly, modifying precursor particles enables the introduction of functional groups into particles while reducing variations in colloidal features, e.g., particle size and size distribution. This powerful synthetic method complements established procedures for functionalization of particle surfaces, thereby enabling the facile preparation of (multi‐)functional particle libraries, which will allow precise investigations of structure–property relations.

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Supra-Amphiphilic Porphyrin Based on Thermoresponsive Poly(N-Isopropylacrylamide-co-2-Acrylamido-2-Methylpropane Sulfonic Acid Sodium) Hydrogels: Synthesis, Characterization and Catalytic Applications

Maddahzadeh-Darini

Ghorbanloo

2022

Catal Lett

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Programmable Nanoassemblies from Non‐Assembling Homopolymers Using Ad Hoc Electrostatic Interactions

Cited by 21 publications

References 52 publications

pH/Redox‐Triggered Photothermal Treatment for Cancer Therapy Based on a Dual‐Responsive Cationic Polymer Dot

pH/Redox‐Triggered Photothermal Treatment for Cancer Therapy Based on a Dual‐Responsive Cationic Polymer Dot

Reactive Precursor Particles as Synthetic Platform for the Generation of Functional Nanoparticles, Nanogels, and Microgels

Supra-Amphiphilic Porphyrin Based on Thermoresponsive Poly(N-Isopropylacrylamide-co-2-Acrylamido-2-Methylpropane Sulfonic Acid Sodium) Hydrogels: Synthesis, Characterization and Catalytic Applications

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