Objectives: A series of 328 evaluable patients with renal cell carcinoma operated by radical
transabdominal nephrectomy with regional lymphadenectomy was reviewed to assess the
prognostic significance of various pathologic parameters (pT, N, M, G and venous involvement)
and the value of lymphadenectomy and of surgery of venous tumor thrombus. Patients
and Methods: The complete charts of 328 patients with renal cell carcinoma available to
follow-up, who were operated between 1970 and 1993, were reviewed. All patients underwent
transabdominal extrafascial nephrosurrenalectomy and in all but 14 metastatic ones a regional
retroperitoneal lymphadenectomy was performed. Surgery of venous tumor thrombus was
performed in 79 patients. Life expectancy according to pT stage, pN stage, M stage, nuclear
grade and venous involvement was calculated by means of the life tables method and differences
in survival were evaluated by means of the log rank test. Correlation analysis and multivariate
data analysis according to the Cox model were also performed. Results: Overall survival
of the 328 patients was 50.70% at 5 years, 35.10% at 10 years and 29% at 15 years. At
multivariate data analysis the most important prognostic factors is the presence of metastases
(8% survival at 5 years and no patient surviving more than 7 years after surgery); tumor grade
was the second prognostic factor and statistically significant differences were also found at life
tables analysis among Gl, G2 and G3 tumors. Local tumor stage was the third leading prognostic
factor at multivariate data analysis and statistically significant differences were also
found at life tables analysis. Nodal and venous involvement had only minor importance at
multivariate data analysis although statistically significant differences were found at life
tables analysis between the pN+ and the pNO patients, also in the absence of venous involvement
and distant metastases. Anyway survival of the pN+M0V0 patients was satisfactorily
high (53.20% at 5 years, 39.10% at 10 years and 16% at 15 and 20 years). In patients with
venous involvement no differences in survival were observed depending on the level reached
by the tumor thrombus; differences in survival were observed between patients with venous
involvement alone (38% surviving at 5 and 10 years) and patients who also had nodal or
distant metastases (5.20% at 5 years and 0% at 10 years). Conclusions: From the review of our
series it seems that the most important prognostic factors are synchronous metastases, tumor
grading and the completeness of tumor exeresis. In fact, the low impact on survival of nodal
involvement by itself is probably due to the completeness of lymphadenectomy. The value of
regional lymphadenectomy is sustained by the high long term survival of N+M0V0 patients.
Regarding venous involvement, it seems that V+ patients free from nodal and distant metastases
may benefit from radical surgery, which on the contrary has only minimal impact on
survival of V+M+/N+ patients.