Prognostische Bedeutung der diastolischen versus systolischen Herzinsuffizienz bei Patienten mit klinisch milder Symptomatik

Jung, Philip; Huber, Thomas S.; Muller, M; König, Alexander; Krötz, Florian; Sohn, Hae-Young

doi:10.1055/s-0031-1299011

Cited by 2 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In relation to the LV structure, a well-known characteristic of patients with HFPEF is the phenotypical profile of a non-significant LV dilatation 4 . The findings of the present study show no differences in LV diastolic diameters between the groups, but the LV mass index was significantly higher in group HFPEF, and this typifies this subtype of patients at the early stage of HFPEF, as already reported in the literature in important studies of population samples with similar characteristics 6 , 27 .…”

Section: Discussionsupporting

confidence: 86%

Ergospirometry and Echocardiography in Early Stage of Heart Failure with Preserved Ejection Fraction and in Healthy Individuals

Garcia¹,

Menezes²,

Stefani³

et al. 2015

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

BackgroundHeart failure with preserved ejection fraction is a syndrome characterized by changes in diastolic function; it is more prevalent among the elderly, women, and individuals with systemic hypertension (SH) and diabetes mellitus. However, in its early stages, there are no signs of congestion and it is identified in tests by adverse remodeling, decreased exercise capacity and diastolic dysfunction.ObjectiveTo compare doppler, echocardiographic (Echo), and cardiopulmonary exercise test (CPET) variables - ergospirometry variables - between two population samples: one of individuals in the early stage of this syndrome, and the other of healthy individuals.MethodsTwenty eight outpatients diagnosed with heart failure according to Framingham’s criteria, ejection fraction > 50% and diastolic dysfunction according to the european society of cardiology (ESC), and 24 healthy individuals underwent Echo and CPET.ResultsThe group of patients showed indexed atrial volume and left ventricular mass as well as E/E’ and ILAV/A´ ratios significantly higher, in addition to a significant reduction in peak oxygen consumption and increased VE/VCO2 slope, even having similar left ventricular sizes in comparison to those of the sample of healthy individuals.ConclusionThere are significant differences between the structural and functional variables analyzed by Echo and CPET when comparing two population samples: one of patients in the early stage of heart failure with ejection fraction greater than or equal to 50% and another of healthy individuals.

show abstract

Section: Discussionsupporting

confidence: 86%

Ergospirometry and Echocardiography in Early Stage of Heart Failure with Preserved Ejection Fraction and in Healthy Individuals

Garcia¹,

Menezes²,

Stefani³

et al. 2015

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

show abstract

Elevated Soluble ST2 and Depression Increased the Risk of All-Cause Mortality and Hospitalization in Patients With Heart Failure

Lü

et al. 2014

Int. Heart J.

View full text Add to dashboard Cite

This study aimed to assess the predictive effect of soluble ST2 (sST2) and depressive symptoms in patients with heart failure (HF) and to determine whether the prognosis of HF patients with preserved ejection fraction (HFpEF) differs from those with reduced ejection fraction (HFrEF). A cohort of 233 HF patients was followed for 1 year. Depressive symptoms were evaluated by the Hospital Anxiety and Depression Scale. The primary endpoint was all-cause mortality and HF-related hospitalization. For the analysis of survival, the left ventricular ejection fraction (LVEF) cut-offs for defining HFpEF were set at 50%, 45%, and 40%, respectively. With increasing LVEF, levels of sST2 were gradually decreased (45.2 ng/mL, 35.8 ng/mL, and 32.1 ng/mL in patients with LVEF ≤ 40%, 41% to 49%, and ≥ 50%, respectively, P for trend < 0.001), as well as the prevalence of depressive symptoms (35.4%, 33.3%, and 20.4%, respectively, P for trend = 0.022). After 1-year follow-up, 128 patients (54.9%) achieved the primary endpoint and 47 patients (20.2%) died. Depressive symptoms were independent risk factors of all-cause mortality and HF-related hospitalization. The combined presence of elevated sST2 (> 36.0 ng/mL) and depressive symptoms was associated with a 4.9-fold increased risk of the primary endpoint. Regardless of LVEF cut-offs, the associated risk of adverse outcomes in HFpEF was as high as in HFrEF after adjustment for significant risk factors including sST2 and N-terminal pro-brain natriuretic peptide. In conclusion, depressive symptoms provided additional prognostic information to that of sST2 in HF patients. The prognosis of HFpEF patients was similar to that of HFrEF patients.

show abstract

Prognostische Bedeutung der diastolischen versus systolischen Herzinsuffizienz bei Patienten mit klinisch milder Symptomatik

Abstract: Patients with HFpEF and mild symptoms have a more benign prognosis than those with systolic heart failure. Whether additional echocardiographic measurements are valuable for the diagnosis of HFpEF has to be proved in larger studies.

Cited by 2 publications

References 10 publications

Ergospirometry and Echocardiography in Early Stage of Heart Failure with Preserved Ejection Fraction and in Healthy Individuals

Ergospirometry and Echocardiography in Early Stage of Heart Failure with Preserved Ejection Fraction and in Healthy Individuals

Elevated Soluble ST2 and Depression Increased the Risk of All-Cause Mortality and Hospitalization in Patients With Heart Failure

Contact Info

Product

Resources

About