Prognostic Variables in Parotid Gland Cancer

Frankenthaler, Robert A.; Luna, Mario A.; Lee, Sang Sook; Ang, K. Kian; Byers, Robert M.; Guillamondegui, Oscar M.; Wolf, Pat; Goepfert, Helmuth

doi:10.1001/archotol.1991.01870230067009

Cited by 164 publications

(100 citation statements)

References 23 publications

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“…[16][17][18] Most reports deal exclusively with either tumors of the major salivary glands (submandibular and parotid glands combined), or tumors of the minor salivary glands, [19][20][21][22][23][24] or tumors of the parotid gland only. [25][26][27][28][29][30][31][32][33][34] We performed an update of the database of the NWHHT concerning all salivary gland cancers irrespective of site and histology. This analysis, which was based on data from all head and neck centers in the Netherlands, included comorbidity scores.…”

Section: Discussionmentioning

confidence: 99%

The prognostic role of comorbidity in salivary gland carcinoma

Terhaard

Schroeff

Schie

et al. 2008

Cancer

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BACKGROUND.Patients with head and neck cancer are prone to develop significant comorbidity mainly because of the high incidence of tobacco and alcohol abuse, both of which are etiologic and prognostic factors. However, to the authors' knowledge little is known regarding the prognostic relevance of comorbidity in patients with salivary gland cancer.METHODS.A retrospective cohort of 666 patients with salivary gland cancer was identified within the Dutch Head and Neck Oncology Cooperative Group database. For multivariate analysis, a Cox proportional hazards model was used to study the effect of comorbidity on overall survival and disease‐specific survival.RESULTS.According to the Adult Comorbidity Evaluation‐27 (ACE‐27) index, 394 patients (64%) had grade 0 comorbidity, 119 patients (19%) had grade 1 comorbidity, 71 patients (12%) had grade 2 comorbidity, and 29 patients (5%) had grade 3 comorbidity. In multivariate analysis for overall survival, the ACE‐27 comorbidity grade was a strong independent prognostic variable. The hazards ratio (HR) of death, including all causes, was 1.5 (95% confidence interval [CI], 1.1‐2.1) for patients with ACE‐27 grade 1 comorbidity versus grade 0 comorbidity (P < .007). The HR was 1.7 (95% CI, 1.2‐2.5) for grade 2 comorbidity (P = .003) and 2.7 (95% CI, 1.5‐4.7) for grade 3 comorbidity versus grade 0 comorbidity (P = .001). In the current analysis, ACE‐27 comorbidity grade was not an independent prognostic factor for disease‐free survival.CONCLUSIONS.To the authors' knowledge, this is the first study concerning the prevalence and relevance of the prognostic comorbidity variable ACE‐27 grade in patients with salivary gland cancer. Overall survival, but not disease‐free survival, was correlated strongly with ACE‐27 grade. Compared with other studies that investigated the effect of comorbidity on patients with head and neck cancer, patients with salivary gland cancer had less comorbidity. Their comorbid status appeared to be reasonably comparable to that of patients with other nonsmoking‐ and nonalcohol‐related cancers. Cancer 2008. © 2008 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

The prognostic role of comorbidity in salivary gland carcinoma

Terhaard

Schroeff

Schie

et al. 2008

Cancer

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“…Malignant mixed tumours arise most commonly as a focus of malignant degeneration within a preexisting benign pleomorphic adenoma (carcinoma ex pleomorphic adenoma). Adenocarcinoma of the parotid develops from the secretory elements of the gland [9,10]. This is an aggressive lesion with potential for both local lymphatic and distant metastases.…”

Section: Discussionmentioning

confidence: 99%

Tumours of Deep Lobe of Parotid Gland: Our Experience

Dass¹,

Gupta²,

Singhal

et al. 2014

Indian J Surg

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Parotidectomy surgeries are being routinely performed by ENT surgeons nowadays. Parotid tumours can present with a variety of manifestations ranging from a barely noticeable mass to a large tumour with facial paralysis. Most benign parotid tumours are located in the superficial lobe though rarely deep lobe may also be involved, while malignant tumours are generally seen to involve both the lobes of the gland. We present clinico-radiological-pathological profile of 25 patients who underwent parotid surgeries for tumours involving deep lobe alone or the whole gland, and were operated at our institute during the period from January 2011 to December 2012. This study was a retroprospective observational analysis with the aim of analyzing the epidemiology, radiological, surgical and histopathological profile of these patients. Among 25 patients who underwent parotid surgeries, 17 patients underwent total conservative parotidectomy, while 5 patients underwent radical parotidectomy. In 3 patients, extended radical parotidectomy was performed. We also report the complications and follow-up of these patients. We concluded that fine needle aspiration cytology (FNAC) findings and final histopathological report may not always correlate.

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“…The factors that were correlated with the presence of occult cervical lymph node metastases were facial paralysis, an older age (>54 years), a high tumor grade, perilymphatic invasion, and extraparotid tumor extension. Interestingly, with the exception of older age, these factors were also associated with increased local recurrence and thus dictate the need for postoperative radiation, regardless of the presence or absence of occult metastases in the regional lymph nodes [23] . Another interesting finding of this study was that occult metastases were discovered by elective dissection of the lymph nodes in only 3% of the patients with low-grade tumors.…”

Section: The Clinically Negative Neckmentioning

confidence: 99%

“…A few years later, similar recommendations were made by Califano et al [26] from the University of Naples. A later study from Memorial Sloan-Kettering suggested that in patients with small, low-grade tumors that are adequately excised, elective treatment of the neck is not necessary [23] . On the other hand, this treatment is warranted in patients whose tumors are larger than 4 cm or are high grade and in whom the risk of occult lymph node metastases is high [24] .…”

Section: The Clinically Negative Neckmentioning

confidence: 99%

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

Medina¹,

Zbären

Bradley

2016

Salivary Gland Neoplasms

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Metastases from salivary gland carcinomas to the cervical lymph nodes are relatively uncommon. However, their impact on prognosis is significant and, thus, it is important to manage them appropriately. Treatment of clinically evident metastases consists primarily of surgery, frequently followed by radiation. Management of the N0 neck, on the other hand, remains controversial. While there seems to be agreement regarding the tumor and patient factors that make it more likely for a patient to harbor subclinical metastases in the lymph nodes, some clinicians prefer to treat those patients with surgery, i.e. a neck dissection, and others prefer to use elective radiation. These different approaches and their rationale will be discussed in detail.

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Prognostic Variables in Parotid Gland Cancer

Cited by 164 publications

References 23 publications

The prognostic role of comorbidity in salivary gland carcinoma

The prognostic role of comorbidity in salivary gland carcinoma

Tumours of Deep Lobe of Parotid Gland: Our Experience

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

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