Prognostic Values of Stabilin-2 in Hepatocellular Carcinoma

Abstract

Background: Hepatocellular carcinoma (HCC) is the primary malignancy of the liver. However, biomarkers for early HCC diagnosis are not available. Stabilin (STAB) proteins are scavenger receptors involved in apoptosis and clearance of hyaluronic acid .The role of STAB in HCC has not been previously explored; therefore, the aim of this study was to assess whether STAB gene expression can be used as a novel HCC biomarker.Materials and Methods: Data on 370 HCC patients in the Cancer Genome Atlas database and 221 patients in the Gene Expression Comprehensive Database were retrieved and analyzed. Kaplan–Meier analysis and Cox regression model were used to calculate median survival time using hazard ratio (HR) and 95% confidence interval (CI). Results: The Gene Expression Omnibus dataset showed that high Stabilin-2（STAB2） expression implies longer overall survival (HR after correction = 0.541; 95% CI, 0.339–0.865; p = 0.0182, after correction p = 0.010) and longer recurrence-free survival time (adjusted HR = 0.554; 95% CI, 0.376-0.816; p = 0.0085, adjusted p = 0.003). Conclusions: STAB2 is a potential biomarker for the diagnosis and prognosis of HCC.

Theabrownin isolated from Pu‐erh tea regulates Bacteroidetes to improve metabolic syndrome of rats induced by high‐fat, high‐sugar and high‐salt diet

“…Stabilin-2 is expressed in high levels in liver, as a scavenger receptor that binds to bacteria, and as a protein that endocytoses modified low-density lipoprotein and the end-products of glycation. 40 The levels of Stab2 in LT, MT and HT groups significantly increased more than two times higher compared to MS group. Steroidogenic acute regulatory protein (STAR) promotes the synthesis of bile acids in the liver and increases the excretion of cholesterol.…”

“…The levels of Pygb in LT, MT and HT groups significantly increased by 3.62, 3.27 and 2.69 times compared with MS group, respectively. Stabilin‐2 is expressed in high levels in liver, as a scavenger receptor that binds to bacteria, and as a protein that endocytoses modified low‐density lipoprotein and the end‐products of glycation 40 . The levels of Stab2 in LT, MT and HT groups significantly increased more than two times higher compared to MS group.…”