Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers

Wang, Jingjing; Wang, Yin-Ling; Ge, Xin-Xin; Xu, Mengdan; Chen, Kai; Wu, Mengyao; Gong, Fei‐Ran; Tao, Min; Wang, Wenjie; Shou, Liu‐Mei; Li, Wei

doi:10.1177/1533033819837261

Cited by 22 publications

(18 citation statements)

References 52 publications

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“…Feng et al found that preoperative platelet count was a predictive factor for long-term survival in ESCC, especially in node-positive patients [24].Ohuchi M et al found that a high platelet count is associated with tumor progression and poor survival in patients with esophageal cancer [25]. For thrombocytosis, even in ammation-based scores, such as PLR, was established to analyzes the prognosis of maglinancies [26][27][28][29]. The reason for our nding con icted with previous studies may be that our sample size was relatively too little and the patients with relative advaned stage compared with previous studies.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with Gallbladder carcinoma

Cao

Jiang

Zhou

et al. 2021

Preprint

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Background: Gallbladder carcinoma (GBC) was the most common malignancy of biliary tract. Patients with malignancies frequently present with activated coagulation pathways, which mightpotentially related to tumor progression and prognosis. The purpose of the study was to investigate the clinical significance of preoperative serum fibrinogen levels and platelet counts in GBC patients.Methods: The preoperative fasting serum fibrinogen levels and platelet counts of 58 patients with GBC were measured by AUV2700 automatic biochemical analyzer, as well as 60 patients with cholesterol polyps and 60 healthy volunteers. Kaplan–Meier survival analysis was applied to show the correction between fibrinogen levels and outcome after surgery.Results: The fibrinogen levels of patients with GBC were significantly higher than healthy gallbladder and cholesterol polyp of gallbladder (p<0.001 and p<0.001,respectively). In GBC, fibrinogen levels were associated with tumor depth (p=0.001), lymph node metastasis (p=0.002), distant metastasis (p<0.001) and Tumor Node Metastasis (TNM) stage (p<0.001).The levels in TNM stage Ⅳ disease were significantly higher than stage Ⅲ or stage Ⅰ+Ⅱ disease（p=0.048 and p<0.001, respectively）, and in TNM stage Ⅲ disease were significantly higher than stageⅠ+Ⅱ disease（p=0.002）.Furthermore, the overall survival was better in low fibrinogen level group than in high fibrinogen level group (p<0.001).However, thrombocytosis was not significantly associated with overall survivals(p>0.05) in univariate analysis.Conclusion: The preoperative serum fibrinogen levels and platelet counts might be reliable biomarkers for the occurance of disease, tumor depth, lymph node metastasis, distant metastasis and advanced TNM stage in patients with GBC. The serum fibrinogen levels might be a prognostic factor to predict outcome for GBC patients suffering from surgery treatment. Anticoagulation therapy might be considered to control cancer progression in future studies.

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Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with Gallbladder carcinoma

Cao

Jiang

Zhou

et al. 2021

Preprint

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“…Liquid biopsy has been shown to be useful for the early detection of cancers compared to CTCs, cell‐free nucleic acids, and exosomes found at lower levels at the early stage 31,32 . Platelet‐associated indicators and platelet counts have been shown to be associated with the prognosis of resectable lung and colorectal cancers 33–35 . Moreover, Best et al 9 used NGS to examine 283 blood platelet samples isolated from healthy controls and patients with cancer and found that RNA profiles of TEPs could be used to diagnose cancer patients with 96% accuracy.…”

Section: Discussionmentioning

confidence: 99%

Identification of seven tumor‐educated platelets RNAs for cancer diagnosis

Yuan

Cheng

et al. 2021

Clinical Laboratory Analysis

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Background Tumor‐educated platelets (TEPs) may enable blood‐based cancer diagnosis. This study aimed to identify diagnostic TEPs genes involved in carcinogenesis. Materials and Methods The TEPs differentially expressed genes (DEGs) between healthy samples and early/advanced cancer samples were obtained using bioinformatics. Gene ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were used to identify the pathways and functional annotation of TEPs DEGs. Protein‐protein interaction of these TEPs DEGs was analyzed based on the STRING database and visualized by Cytoscape software. The correlation analysis and diagnostic analysis were performed to evaluate the diagnostic value of TEPs mRNAs expression for early/advanced cancers. Quantitative real‐time PCR (qRT‐PCR) was applied to validate the role of DEGs in cancers. Results TEPs mRNAs were mostly involved in protein binding, extracellular matrix, and cellular protein metabolic process. RSL24D1 was negatively correlated to early‐stage cancers compared to healthy controls and may be potentially used for early cancer diagnosis. In addition, HPSE, IFI27, LGALS3BP, CRYM, HBD, COL6A3, LAMB2, and IFITM3 showed an upward trend in the expression from early to advanced cancer stages. Moreover, ARL2, FCGR2A, and KLHDC8B were positively associated with advanced, metastatic cancers compared to healthy controls. Among the 12 selected DEGs, the expression of 7 DEGs, including RSL24D1, IFI27, CRYM, HBD, IFITM3, FCGR2A, and KLHDC8B, were verified by the qRT‐PCR method. Conclusion This study suggests that the 7‐gene TEPs liquid‐biopsy biomarkers may be used for cancer diagnosis and monitoring.

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“…Platelets-associated indicators and platelet counts have been shown associated with the prognosis of resectable lung and colorectal cancers [37][38][39]. In addition to the predictive role of platelets-associated indicators in cancer, platelet counts, or protein markers, Best et.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

Ge¹,

Yuan²,

Hu³

et al. 2020

Preprint

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Cancer is a disturbing disease with high morbidity and mortality. Although medical technology has been developed rapidly, diagnosis of cancer is still complicated, difficult, as well as expensive. Furthermore, cancers are mostly diagnosed at an advanced stage. Platelets mRNA profiles are altered after educated by tumors. Thereby, tumor-educated platelets (TEPs) mRNA profiles have the potentially diagnostic value for cancers currently. We downloaded and analyzed the next-generation sequencing datasets, GSE68086 and GSE89843, by integrated bioinformatics. A total of 43 biomarker genes were selected for further pathway enrichment analysis and correlation analysis, as well as diagnostic analysis. Gene ontology (GO) analysis showed these 43 TEPs mRNAs were mostly involved in protein binding, extracellular matrix and cellular protein metabolic process. Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis revealed that genes were mainly enriched in metabolic process. Eventually, after taking these 43 genes into spearman correlation analysis and receiving operating characteristic (ROC) curve analysis, we identified: 1) TEPs RSL24D1 mRNA was negatively related to early pan cancer as compared to healthy controls, and potential for early pan cancer diagnosis with a sensitivity of 71.8%, and a specificity of 64.3%; 2) HPSE, IFI27, LGALS3BP, CRYM, HBD, COL6A3, LAMB2, and IFITM3 showed an upward trend in the expression from early to more advanced pan cancer stages. The sensitivity of the diagnostic value for pan cancer of these genes was 60.9%, 59.1%, 56.5%, 57.8%, 54.3%, 55.2%, 55.2%, 60.9%, and a specificity of 94.5%, 90.9%, 87.3%, 89.1%, 72.7%, 85.5%, 89.1%, 94.5% respectively; 3) ARL2, FCGR2A, and KLHDC8B were positively associated with advanced, metastatic pan cancer as compared to healthy controls and could be diagnostic indicators for advanced pan cancer with a sensitivity of 59.2%, 61.8%, 59.7%, and a specificity of 80%, 89.1%, 83.6%, respectively. In summary, our findings identified that the 12-gene TEP liquid-biopsy biomarkers will not only facilitate early diagnosis of pan cancer, but also be beneficial to pan cancer staging.

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Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers

Cited by 22 publications

References 52 publications

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with Gallbladder carcinoma

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with Gallbladder carcinoma

Identification of seven tumor‐educated platelets RNAs for cancer diagnosis

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

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