Prognostic values of perfusion-metabolic mismatch in Tl-201 and BMIPP scintigraphic imaging in patients with chronic coronary artery disease and left ventricular dysfunction undergoing revascularization

Abstract

In revascularized patients with severe LV dysfunction, the presence of a large amount of perfusionmetabolic mismatch evaluated by Tl-201 and BMIPP imaging identifies patients with the best prognosis.

A low perfusion‐metabolic mismatch in 99mTl and 123I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

“…Some reports supported our findings that a low mismatch score was associated with poor prognosis. Patients with ischemic heart disease who had a low mismatch scores tended to have worse prognoses compared to those with high mismatch scores after recanalization . Existence of metabolically impaired but viable myocardium may result in high mismatch score and this predicted good prognosis.…”

Prognostic value of myocardial metabolic imaging with BMIPP in the spectrum of coronary artery disease: A systematic review

“…20 This suggests that the mismatched myocardium before revascularization represents a hibernating myocardium or a jeopardized (but viable) myocardium. Successful revascularization of such a myocardium may therefore confer survival benefit.…”

“…The final set therefore comprised 11 studies, all of which were conducted in Japan. [10][11][12][13][14][15][16][17][18][19][20] The selected studies were published between 1996 and 2008. The number of participants per study ranged from 33 to 270 for 1,315 participants across studies.…”

Role of Fatty Acid Imaging with 123I- β-methyl-p-123I- Iodophenyl-Pentadecanoic Acid (123I-BMIPP) in Ischemic Heart Diseases

“…In the patients with chronic stage of myocardial infarction, clinical value of BMIPP imaging for predicting prognosis is also demonstrated. BMIPP imaging performed before revascularization in 76 patients with chronic stable ischemia (including 61 patients with myocardial infarction after at least 3 month of onset) with left ventricular dysfunction has been analyzed [97]. Patients with large amount of discordant BMIPP uptake less than thallium demonstrated greater ejection fraction improvement after revascularization and, interestingly, showed significantly better event free survival than patients with small amount or no perfusion and metabolic mismatch.…”