Prognostic values of coronary artery calcium score and 123I-BMIPP SPECT in patients with non-ischemic heart failure with preserved ejection fraction

Abstract

This study aimed to determine whether coronary artery calcium score (CACS) can be a prognostic indicator for the development of major adverse cardiac events (MACEs) and compare the value of CACS with that of the 123 I-betamethyl-p-iodophenyl-pentadecanoic acid ( 123 I-BMIPP) defect score (BDS) in patients with non-ischemic heart failure with preserved ejection fraction (NIHFpEF). MethodsAmong 643 consecutive patients hospitalized due to acute heart failure, 108 (74 ± 13y) were identi ed to have NIHFpEF on non-contrast regular chest computed tomography and 123 I-BMIPP single-photon emission computed tomography (SPECT). We evaluated whether CACS and BDS were associated with MACEs using multivariate Cox models. ResultsThirty-two MACEs developed at a mean follow-up period of 2.4 years. Higher CACS (hazard ratio [HR] 2.27, 95% con dence interval [CI] 1.10-4.67) and higher BDS (HR 22.14, 95% CI 7.95-61.60) were signi cantly associated with the development of MACEs. Patients showing higher CACS and BDS carried a signi cantly higher risk for developing MACE (HR 23.65, 95% CI 10.33-54.13, p < 0.001). ConclusionCACS, as well as BDS, could serve as potential prognostic indicators in patients with NIHFpEF.