Prognostic value of γ-glutamyl transpeptidase to albumin ratio combined with aspartate aminotransferase to lymphocyte ratio in patients with hepatocellular carcinoma after hepatectomy

Abstract

Hepatocellular carcinoma (HCC) is a malignant tumor associated with a high recurrence rate after hepatectomy. Recently, preoperative inflammatory and liver function reserve indices were found to predict increased risk of recurrence and decreased survival in HCC patients. This study aims to evaluate the ability of the γ-glutamyl transpeptidase-to-albumin ratio (GAR) and aspartate aminotransferase-to-lymphocyte ratio (ALRI), individually and in combination, to predict the prognosis of HCC patients after hepatectomy. We retrospectively reviewed 206 HCC patients who underwent radical resection at the General Hospital of Ningxia Medical University from January 2011 to November 2016. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cut-off value for GAR and ALRI. The Pearson Chi-Squared test was used to analyze the correlations between GAR, ALRI and clinicopathological characteristics. Univariate and multivariate analyses were used to determine the predictive value of these factors for disease-free survival (DFS) and overall survival (OS). Survival rates were drawn according to the Kaplan-Meier method and differences between subgroups were compared by the log-rank statistics. GAR and ALRI were significantly correlated with gender, history of smoking, prothrombin time, tumor diameter, T stage and early intrahepatic recurrence by the Pearson Chi-Squared test (all P < .05). Univariate analysis indicated that T stage, GAR and ALRI were significantly correlated with DFS and OS in HCC patients after hepatectomy. Multivariate analysis illustrated that GAR and ALRI were independently related to DFS and OS in HCC patients. Preoperative GAR > 0.946 or ALRI > 18.734 predicted poor prognosis in HCC patients after hepatectomy. Additionally, the predictive scope of GAR combined with ALRI was more sensitive than that of either individual measurement alone. Our data indicate that there is a close association between the clinicopathological characteristics in HCC patients and increased GAR or ALRI. Higher levels of GAR and ALRI could sensitively and specifically predict a poor prognosis in HCC patients after hepatectomy. Furthermore, combined usage of GAR and ALRI could improve the accuracy of this prediction.

New Insights Into a Classification-Based Microvascular Invasion Prediction Model in Hepatocellular Carcinoma: A Multicenter Study

“…For a detailed discussion of the potential mechanisms by which serum γ-GGT level may have prognostic value in patients with HCC, the reader is referred to Sun and colleagues’ meta-analysis of 18 studies from China and 2 studies from western countries ( 45 ). Since Sun’s review was published, subsequent γ-GGT studies of HCC have been conducted primarily in HBV-endemic areas ( 40 , 41 , 43 , 44 ). It would be of interest to determine whether γ-GGT may be a more valuable marker in HBV-related HCC than in non-HBV-related HCC.…”

Non-Linear Relationship of Gamma-Glutamyl Transpeptidase To Lymphocyte Count Ratio With The Recurrence of Hepatocellular Carcinoma with Staging I-II: A Retrospective Cohort Study

“…In recent years, the prediction model of prognosis of the HCC combined with different in ammation factors has always been a hot issue [9,10,29,30]. Previous studies have examined GLR's prognostic ability in HCC [14,31], intrahepatic cholangiocarcinoma [32] and nonfunctional pancreatic neuroendocrine tumors [25].…”

Prognostic and Clinical Significance of Aspartate Aminotransferase-to-Lymphocyte Ratio Index in Individuals with Liver Cancer: A Meta-Analysis

“…The primary literature search retrieved 81 articles. After removing duplicate publications and reviewing the abstracts, only eleven clinical studies [13][14][15][16][17][18][19][20][21][22][23] that fulfilled the inclusion criteria were ultimately included in this meta-analysis. The process of the literature selection is presented in Figure 1.…”

“…The aspartate aminotransferase-(AST-) to-lymphocyte ratio index (ALRI) is a novel inflammatory index for HCC [12] and is derived from the ratio of AST to lymphocyte count. ALRI has been reported to be related to the survival of patients with HCC [13][14][15][16][17][18][19][20][21][22][23]; however, results have not been consistent across studies. Therefore, we conducted the current meta-analysis to determine the prognostic impact and clinical significance of ALRI in patients with HCC by aggregating all available data.…”