Prognostic value of volumetric parameters measured by F-18 FDG PET/CT in surgically resected non-small-cell lung cancer

Kim, Keunyoung; Kim, Seong-Jang; Kim, In Joo; Kim, Yun Seong; Pak, Kyoungjune; Kim, Heeyoung

doi:10.1097/mnm.0b013e328351d4f5

Cited by 76 publications

(55 citation statements)

References 27 publications

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“…MTV is a volumetric or quantitative measurement of tumor cells with high glycolitic activity, that recently has been suggested as an independent factor of prognosis in several cancers [10,[17][18][19][20]. Chung et al [10] demonstrated that the preoperative MTV more than or equal to 23.4 ml was an independent prognostic factor for disease free survival in patients with stage IB to IIA cervical cancer treated by radical surgery.…”

Section: Dicussionmentioning

confidence: 98%

18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer

Crivellaro

Signorelli

Guerra

et al. 2012

Gynecologic Oncology

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Section: Dicussionmentioning

confidence: 98%

18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer

Crivellaro

Signorelli

Guerra

et al. 2012

Gynecologic Oncology

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“…For non-small cell lung cancer (NSCLC), 18 F-FDG PET/CT image quantification has been shown to provide prognostic information. PET image-derived features, including metabolically active tumor volume (MATV), mean standardized uptake value (SUV mean ), and total lesion glycolysis (TLG, defined as MATV · SUV mean ), have been shown to provide an accurate assessment of tumor burden with potentially higher prognostic value than standard maximum SUV (SUV max ), for both surgical and nonsurgical patients (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Visual Versus Quantitative Assessment of Intratumor ¹⁸F-FDG PET Uptake Heterogeneity: Prognostic Value in Non–Small Cell Lung Cancer

et al. 2014

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The goal of this study was to compare visual assessment of intratumor 18 F-FDG PET uptake distribution with a textural-features (TF) automated quantification and to establish their respective prognostic value in non-small cell lung cancer (NSCLC). Methods: The study retrospectively included 102 consecutive patients. Only primary tumors were considered. Intratumor heterogeneity was visually scored (3-level scale [H visu ]) by 2 nuclear medicine physicians. Tumor volumes were automatically delineated, and heterogeneity was quantified with TF. Mean and maximum standardized uptake value were also included. Visual interobserver agreement and correlations with quantitative assessment were evaluated using the κ test and Spearman rank (ρ) coefficient, respectively. Association with overall survival and recurrencefree survival was investigated using the Kaplan-Meier method and Cox regression models. Results: Moderate correlations (0.4 , ρ , 0.6) between TF parameters and H visu were observed. Interobserver agreement for H visu was moderate (κ 5 0.64, discrepancies in 27% of the cases). High standardized uptake value, large metabolic volumes, and high heterogeneity according to TF were associated with poorer overall survival and recurrence-free survival and remained an independent prognostic factor of overall survival with respect to clinical variables. Conclusion: Quantification of 18 F-FDG uptake heterogeneity in NSCLC through TF was correlated with visual assessment by experts. However, TF also constitutes an objective heterogeneity quantification, with reduced interobserver variability, and independent prognostic value potentially useful for patient stratification and management. PET/ CT imaging with 18 F-FDG is today a well-established tool for diagnostic oncology applications (1). Its exploitation for tumor delineation in the planning of radiotherapy treatment (2) or monitoring of response to therapy (3,4) is increasing. For non-small cell lung cancer (NSCLC), 18 F-FDG PET/CT image quantification has been shown to provide prognostic information. PET image-derived features, including metabolically active tumor volume (MATV), mean standardized uptake value (SUV mean ), and total lesion glycolysis (TLG, defined as MATV · SUV mean ), have been shown to provide an accurate assessment of tumor burden with potentially higher prognostic value than standard maximum SUV (SUV max ), for both surgical and nonsurgical patients (5-9).Intratumor 18 F-FDG uptake heterogeneity has been associated with treatment failure (10), and its quantification has recently generated interest (11-14), including in lung cancer (15). Several methodologies have been proposed to assess intratumor heterogeneity, including visual evaluation (16), SUV coefficient of variation (SUV COV ) (17), area under the curve of the cumulative histogram (CH AUC ) (18), and textural-features (TF) analysis (17,19).TF analysis can generate many features quantifying heterogeneity within a delineated MATV. Recent studies have identified a few of these features that are ...

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“…The inclusion of WB PET values in the software system, especially for the evaluation of more common and aggressive cancers (i.e. breast cancer, lung cancer, head and neck cancer, colon-rectal cancer), should be considered, in accordance with most recent evidence [14,17,24,25].…”

Section: Discussionmentioning

confidence: 91%

Could semiquantitative FDG analysis add information to the prognosis in patients with stage II/III breast cancer undergoing neoadjuvant treatment?

Evangelista

Cervino

Ghiotto

et al. 2015

Eur J Nucl Med Mol Imaging

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Prognostic value of volumetric parameters measured by F-18 FDG PET/CT in surgically resected non-small-cell lung cancer

Abstract: Volume-based parameters of F-18 FDG PET-CT may have a role in providing prognostic information in NSCLC patients who have received surgical treatment.

Cited by 76 publications

References 27 publications

18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer

18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer

Visual Versus Quantitative Assessment of Intratumor ¹⁸F-FDG PET Uptake Heterogeneity: Prognostic Value in Non–Small Cell Lung Cancer

Could semiquantitative FDG analysis add information to the prognosis in patients with stage II/III breast cancer undergoing neoadjuvant treatment?

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Prognostic value of volumetric parameters measured by F-18 FDG PET/CT in surgically resected non-small-cell lung cancer

Abstract: Volume-based parameters of F-18 FDG PET-CT may have a role in providing prognostic information in NSCLC patients who have received surgical treatment.

Cited by 76 publications

References 27 publications

18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer

18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer

Visual Versus Quantitative Assessment of Intratumor 18F-FDG PET Uptake Heterogeneity: Prognostic Value in Non–Small Cell Lung Cancer

Could semiquantitative FDG analysis add information to the prognosis in patients with stage II/III breast cancer undergoing neoadjuvant treatment?

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Visual Versus Quantitative Assessment of Intratumor ¹⁸F-FDG PET Uptake Heterogeneity: Prognostic Value in Non–Small Cell Lung Cancer