Prognostic value of tumour deposit and perineural invasion status in colorectal cancer patients: a <scp>SEER</scp>‐based population study

Mayo, Erin; Llanos, Adana A.M.; Yi, Xianghua; Duan, Si‐Bo; Zhang, Lanjing

doi:10.1111/his.12936

Cited by 62 publications

(50 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This factor indeed shows a high contribution coefficient in our nomogram. Perineural invasion is a possible pathway for metastatic diffusion of tumors, which can lead to poor prognosis of tumors [33,34]. The prognostic value of this variable is also reflected in our model.…”

Section: Discussionmentioning

confidence: 85%

A competing-risk nomogram to predict cause-specific death in elderly patients with colorectal cancer after surgery (especially for colon cancer)

Wang¹,

Wang²,

Yang³

et al. 2020

World J Surg Onc

View full text Add to dashboard Cite

Background: Clinically, when the diagnosis of colorectal cancer is clear, patients are more concerned about their own prognosis survival. Special population with high risk of accidental death, such as elderly patients, is more likely to die due to causes other than tumors. The main purpose of this study is to construct a prediction model of cause-specific death (CSD) in elderly patients using competing-risk approach, so as to help clinicians to predict the probability of CSD in elderly patients with colorectal cancer. Methods: The data were extracted from Surveillance, Epidemiology, and End Results (SEER) database to include ≥ 65-year-old patients with colorectal cancer who had undergone surgical treatment from 2010 to 2016. Using competing-risk methodology, the cumulative incidence function (CIF) of CSD was calculated to select the predictors among 13 variables, and the selected variables were subsequently refined and used for the construction of the proportional subdistribution hazard model. The model was presented in the form of nomogram, and the performance of nomogram was bootstrap validated internally and externally using the concordance index (Cindex). Results: Dataset of 19,789 patients who met the inclusion criteria were eventually selected for analysis. The fiveyear cumulative incidence of CSD was 31.405% (95% confidence interval [CI] 31.402-31.408%). The identified clinically relevant variables in nomogram included marital status, pathological grade, AJCC TNM stage, CEA, perineural invasion, and chemotherapy. The nomogram was shown to have good discrimination after internal validation with a C-index of 0.801 (95% CI 0.795-0.807) as well as external validation with a C-index of 0.759 (95% CI 0.716-0.802). Both the internal and external validation calibration curve indicated good concordance between the predicted and actual outcomes. Conclusion: Using the large sample database and competing-risk analysis, a postoperative prediction model for elderly patients with colorectal cancer was established with satisfactory accuracy. The individualized estimates of CSD outcome for the elderly patients were realized.

show abstract

Section: Discussionmentioning

confidence: 85%

A competing-risk nomogram to predict cause-specific death in elderly patients with colorectal cancer after surgery (especially for colon cancer)

Wang¹,

Wang²,

Yang³

et al. 2020

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…This forced us to match only 33 N1 cM0 tumours, decreasing the effect of N1c and the power of our study. However, this high rate of synchronous metastases highlights the major oncological impact of TDs .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value and characteristics of N1c colorectal cancer

Bouquot¹,

Creavin

Goasguen³

et al. 2018

Colorectal Disease

View full text Add to dashboard Cite

show abstract

“…In the CRC patients with metastatic lymph nodes, the prognostic value of TD status was neglected in AJCC staging system, which aroused worldwide discussion [7,14,15]. Mayo et al [16] showed that TDs were associated with worse 3-year OS overall survival in patients of any known and unknown N categories, which suggested that TDs might be associated with a risk of all-cause death or cancer-specific death at least similar to a positive lymph node in all N categories. Basnet et al [17] signified that TD was an independent prognostic factor associated with metastatic diseases along with vascular invasion and the number of metastatic lymph nodes among CRC patients.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery

Zheng

Cheng

et al. 2020

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated. This study is aimed at exploring the prognostic value of TD count and finding out the optimal cutoff point of TD count to differentiate the prognoses of TD-positive CRC patients. Method. Patients diagnosed with CRC from Surveillance, Epidemiology, and End Results (SEER) database from January 1, 2010, to December 31, 2012, were analyzed. X-tile program was used to identify the optimal cutoff point of TD count in training cohort, and a validation cohort was used to test this cutoff point after propensity score matching (PSM). Univariate and multivariate Cox proportional hazard models were used to assess the risk factors of survival. Results. X-tile plots identified 3 (P<0.001) as the optimal cutoff point of TD count to divide the patients of training cohort into high and low risk subsets in terms of disease-specific survival (DSS). This cutoff point was validated in validation cohort before and after PSM (P<0.001, P=0.002). More TD count, which was defined as more than 3, was validated as an independent risk prognostic factor in univariate and multivariate analysis (P<0.001). Conclusion. More TD count (TD count≥4) was significantly associated with poor disease-specific survival in CRC patients.

show abstract

Prognostic value of tumour deposit and perineural invasion status in colorectal cancer patients: a SEER‐based population study

Abstract: Tumour deposit and PNI correlate independently with worse 3-year OS and CSS. TD appears prognostically more important in the CRC of lower N categories.

Cited by 62 publications

References 19 publications

A competing-risk nomogram to predict cause-specific death in elderly patients with colorectal cancer after surgery (especially for colon cancer)

A competing-risk nomogram to predict cause-specific death in elderly patients with colorectal cancer after surgery (especially for colon cancer)

Prognostic value and characteristics of N1c colorectal cancer

The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery

Contact Info

Product

Resources

About