Prognostic value of tumour‐associated macrophages in canine mammary tumours

Raposo, Teresa P; Gregório, Hugo; Pires, Isabel; Prada, Justina; Queiroga, Felisbina L.

doi:10.1111/j.1476-5829.2012.00326.x

Cited by 42 publications

(43 citation statements)

References 51 publications

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“…Tumour‐associated macrophages frequently present characteristics of M2‐phenotype macrophages which are associated with neoangiogenesis, tumour proliferation and consequently a worse prognosis in several different neoplasias . In canine cancers, increased macrophage infiltration has already been proven to have a negative prognostic value in canine mammary tumours . Our study also found an association between macrophage infiltration and markers of tumour proliferation and higher histological grade, but no association was found with angiogenesis.…”

Section: Discussionsupporting

confidence: 60%

High COX‐2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival

Gregório

Raposo

Queiroga

et al. 2016

Vet Comparative Oncology

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COX-2 overexpression is associated with several hallmarks of carcinogenesis such as proliferation, angiogenesis, invasion and metastasis. Fifty cases of canine mast cell tumours (MCT) were retrospectively evaluated and submitted to immunohistochemistry for COX-2, CD31, Ki-67, MAC-387 and CD3. Furthermore its relationship with clinicopathological variables and overall survival (OS) was analysed. COX-2 intensity (P = 0.016), but not COX-2 extension nor score was associated with decreased OS and higher grades of malignancy according to Patnaik (P = 0.002) and Kiupel (P < 0.001) grading systems. Cox-2 intensity was also associated with higher Ki-67 scores (P = 0.009), higher mitotic index (P = 0.022) and higher microvascularization density (P = 0.045). No association was observed for COX-2 intensity and CD3-T lymphocyte (P = 0.377) and macrophage infiltration (P = 0.261) by MAC-387 immunollabelling, suggesting an active role of COX-2 in MCT oncogenesis mainly through proliferation and angiogenesis stimulation making it a potentially clinical relevant prognosis marker and therapeutic target.

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Section: Discussionsupporting

confidence: 60%

High COX‐2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival

Gregório

Raposo

Queiroga

et al. 2016

Vet Comparative Oncology

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“…A positive correlation between microvessel density and mast cells in malignant canine mammary cancer was found, which, in turn, suggests that these immune cells play an important role in canine mammary cancer angiogenesis, similar to human breast cancer [53]. TAMs in canine mammary cancer have already been associated, by our group, with skin ulceration, histological type, nuclear grade, tubular differentiation, and decrease in overall survival [56]. Similarly to human breast cancer, in canine mammary cancer the macrophages also polarize toward the M2 phenotype [57].…”

Section: Inflammatory Cells and Sustained Angiogenesismentioning

confidence: 83%

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Carvalho

Silva-Carvalho

Pires

et al. 2016

BioMed Research International

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Infiltrating cells of the immune system are widely accepted to be generic constituents of tumor microenvironment. It has been well established that the development of mammary cancer, both in humans and in dogs, is associated with alterations in numbers and functions of immune cells at the sites of tumor progression. These tumor infiltrating immune cells seem to exhibit exclusive phenotypic and functional characteristics and mammary cancer cells can take advantage of signaling molecules released by them. Cancer related inflammation has an important role in mammary carcinogenesis, contributing to the acquisition of core hallmark capabilities that allow cancer cells to survive, proliferate, and disseminate. Indeed, recent studies in human breast cancer and in canine mammary tumors have identified a growing list of signaling molecules released by inflammatory cells that serve as effectors of their tumor-promoting actions. These include the COX-2, the tumor EGF, the angiogenic VEGF, other proangiogenic factors, and a large variety of chemokines and cytokines that amplify the inflammatory state. This review describes the intertwined signaling pathways shared by T-lymphocytic/macrophage infiltrates and important tissue biomarkers in both human and dog mammary carcinogenesis.

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“…TAMs have also been implicated in promoting tumor invasion and angiogenesis as well as having immunosuppressive effects on the anti-tumor response of lymphocytes by producing various cytokines and chemokines (Nielsen and Schmid, 2017). TAM infiltration has also been associated with vascular endothelial growth factor expression and linked to poor prognosis in canine breast carcinoma (Raposo et al, 2014;Raposo et al, 2015). It is suggested that the peripheral monocyte level correlates with TAM density of the tumor microenvironment (Shibutani et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Lymphocyte-to-Monocyte Ratio in Canine High-Grade Lymphoma Cases.

Tagawa¹,

Shimbo²,

Matsumoto³

et al. 2019

jwpr

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The Lymphocyte-to-Monocyte Ratio (LMR) has been described as a useful prognostic marker for human patients with various cancers and dogs with diffuse large B-cell lymphoma. The objective of this study was to determine whether the LMR could predict disease outcome as measured by the Time To Progression (TTP) and Overall Survival (OS) of dogs with different types of high-grade lymphoma. The medical records of 43 dogs diagnosed with high-grade lymphoma at the Veterinary Medical Center of Obihiro University of Agriculture and Veterinary Medicine between 2013 and 2018, were retrospectively analyzed. Receiver Operating Characteristic (ROC) curve analysis was used to determine the optimal LMR cutoff values. The prognostic influence of the LMR and other clinicopathological data on TTP and OS was studied by Kaplan-Meier curves. To identify the independent prognostic factors, univariate and multivariate Cox proportional analyses were used. The optimal cutoff value of the LMR was 0.7, which corresponded to the maximum sensitivity (0.727) and specificity (0.762) of the LMR for predicting the median days of OS with ROC analysis (area under the curve, 0.794). Log-rank tests showed that dogs with a high LMR had significantly longer TTP and OS than dogs with a low LMR. Moreover, immunophenotype, body weight, treatment regimen and response to treatment were significantly associated with TTP and OS. In multivariate analysis, treatment and response to treatment were independent risk factors for TTP. Moreover, the LMR, treatment regimen and response to treatment were independent predictors of OS.

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Prognostic value of tumour‐associated macrophages in canine mammary tumours

Cited by 42 publications

References 51 publications

High COX‐2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival

High COX‐2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Prognostic Value of Lymphocyte-to-Monocyte Ratio in Canine High-Grade Lymphoma Cases.

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