Prognostic Value of Tumor Associated Macrophage Markers CD163 and CD68 Immunohistochemistry in Classical Hodgkin Lymphoma

Rashed, Reham A; Zaki, Mohamed A.; Mohamed, Nahed Thabet; Mansou, Osman M; Refaey, Fatma A H El

doi:10.7754/clin.lab.2020.200920

Cited by 5 publications

(4 citation statements)

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“…The lower level of M2 macrophages has been linked to a complete response and better survival [305]. The expressions of both TAM markers, CD68, and CD163 [306] are essential predictors of complete remission in CHL patients [307]. A high ratio of LAMs to Hodgkin-Reed-Sternberg cells at diagnosis is associated with a higher risk of CHL progression or death [308].…”

Section: Hodgkin Lymphomamentioning

confidence: 99%

Macrophage-Based Therapeutic Strategies in Hematologic Malignancies

Khalili,

Zeinali,

Moghadam Fard

et al. 2023

Cancers

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Macrophages are types of immune cells, with ambivalent functions in tumor growth, which depend on the specific environment in which they reside. Tumor-associated macrophages (TAMs) are a diverse population of immunosuppressive myeloid cells that play significant roles in several malignancies. TAM infiltration in malignancies has been linked to a poor prognosis and limited response to treatments, including those using checkpoint inhibitors. Understanding the precise mechanisms through which macrophages contribute to tumor growth is an active area of research as targeting these cells may offer potential therapeutic approaches for cancer treatment. Numerous investigations have focused on anti-TAM-based methods that try to eliminate, rewire, or target the functional mediators released by these cells. Considering the importance of these strategies in the reversion of tumor resistance to conventional therapies and immune modulatory vaccination could be an appealing approach for the immunosuppressive targeting of myeloid cells in the tumor microenvironment (TME). The combination of reprogramming and TAM depletion is a special feature of this approach compared to other clinical strategies. Thus, the present review aims to comprehensively overview the pleiotropic activities of TAMs and their involvement in various stages of cancer development as a potent drug target, with a focus on hematologic tumors.

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Section: Hodgkin Lymphomamentioning

confidence: 99%

Macrophage-Based Therapeutic Strategies in Hematologic Malignancies

Khalili,

Zeinali,

Moghadam Fard

et al. 2023

Cancers

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“…Tumor associated macrophages and monocytes significantly associated with primary treatment failure and with an increased likelihood of relapse after autologous hematopoietic stem-cell transplantation. In immunohistochemical analyses, the number of CD68+ tumor-infiltrating macrophages correlated with shortened PFS [ 59 , 76 ]. Furthermore, the percentage of cytotoxic-T cells in Hodgkin Lymphoma is significantly associated with poor outcome and identified as an independent biological prognostic marker [ 76 ].…”

Section: Pathophysiological Backgroundmentioning

confidence: 99%

“…In immunohistochemical analyses, the number of CD68+ tumor-infiltrating macrophages correlated with shortened PFS [ 59 , 76 ]. Furthermore, the percentage of cytotoxic-T cells in Hodgkin Lymphoma is significantly associated with poor outcome and identified as an independent biological prognostic marker [ 76 ].…”

Section: Pathophysiological Backgroundmentioning

confidence: 99%

Filling the Gap: The Immune Therapeutic Armamentarium for Relapsed/Refractory Hodgkin Lymphoma

Leroyer

Ziegler

Moulin

et al. 2022

JCM

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Despite years of clinical progress which made Hodgkin lymphoma (HL) one of the most curable malignancies with conventional chemotherapy, refractoriness and recurrence may still affect up to 20–30% of patients. The revolution brought by the advent of immunotherapy in all kinds of neoplastic disorders is more than evident in this disease because anti-CD30 antibodies and checkpoint inhibitors have been able to rescue patients previously remaining without therapeutic options. Autologous hematopoietic cell transplantation still represents a significant step in the treatment algorithm for chemosensitive HL; however, the possibility to induce complete responses after allogeneic transplant procedures in patients receiving reduced-intensity conditioning regimens informs on its sensitivity to immunological control. Furthermore, the investigational application of adoptive T cell transfer therapies paves the way for future indications in this setting. Here, we seek to provide a fresh and up-to-date overview of the new immunotherapeutic agents dominating the scene of relapsed/refractory HL. In this optic, we will also review all the potential molecular mechanisms of tumor resistance, theoretically responsible for treatment failures, and we will discuss the place of allogeneic stem cell transplantation in the era of novel therapies.

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“…In addition, the effects of pretreatment with clodronate-containing liposomes, which cause selective macrophage depletion in vivo [12], on the cocoa butter-mediated changes in the mesenteric lymph ow and the concentrations of cells, IL-1β, IL-6 and IL-10 levels in the lymph were investigated. Immunohistochemical studies for the distribution of macrophage using markers of macrophage CD68 and F4/80 [4,15] in rat jejunum were also conducted following the pretreatment with clodronate-containing liposomes. Finally, to clarify the mechanisms underlying the effects of cocoa butter intake on changes in the concentrations of IL-1β, IL-6 and IL-10 in the lymph, in in vitro cells experiments were conducted using a TLR 2 and 4 inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Gut immunity is regulated by cocoa butter intake-mediated release of IL-1β, IL-6 and IL-10

Arai

Kajihara

Takasaka

et al. 2022

Preprint

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Mesenteric lymph has received attention for its important roles in nutrient absorption and mucosal immunity. It contains cytokines and immune cells that control the immune responses. The aim of this study to evaluate the effects of cocoa butter intake on rat mesenteric lymph flow, cell density, and the IL-1β, IL-6 and IL-10 levels in the lymph. Cocoa butter intake increased the lymph flow, cell density and the cytokine levels in the lymph. Clodronate released IL-1β, IL-6 and IL-10 and slightly accelerated the cocoa butter intake-mediated release of IL-6, but not that of IL-1β and IL-10. A Toll-like receptor (TLR) 2 and 4 inhibitor significantly reduced the linoleic acid-mediated releases of IL-1β, IL-6 and IL-10 in the medium of isolated cells from lamina propria of jejunal villi. Our findings suggest that cocoa butter intake regulates gut immunity through the release of IL-1β, IL-6 and IL-10 via a negative feedback mechanism.

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Prognostic Value of Tumor Associated Macrophage Markers CD163 and CD68 Immunohistochemistry in Classical Hodgkin Lymphoma

Cited by 5 publications

References 0 publications

Macrophage-Based Therapeutic Strategies in Hematologic Malignancies

Macrophage-Based Therapeutic Strategies in Hematologic Malignancies

Filling the Gap: The Immune Therapeutic Armamentarium for Relapsed/Refractory Hodgkin Lymphoma

Gut immunity is regulated by cocoa butter intake-mediated release of IL-1β, IL-6 and IL-10

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