Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Huang, Yujing; Qi, Wei-Xiang; He, Aina; Sun, Yaping; Shen, Zan; Yang, Ye

doi:10.7314/apjcp.2013.14.2.645

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…Furthermore, ALCAM loss/downregulation is associated with a more invasive phenotype and poorer outcome in BC [49]. Since the key-role of VEGFA in vimentin expression promoting EMT changes [50] and chemoresistance [51] in BC cells, VEGFA overexpression may be partially responsible for the acquisition of the EMT phenotype and drug resistance found in CPS-treated BC cells.…”

Section: Discussionmentioning

confidence: 99%

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

et al. 2016

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Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC cells.Here we found that treatment of high-grade BC cells with high dose of CPS triggers autophagy. Infact, the CPS treatment alters the redox homeostasis by inducing production of radicals, mitochondrial depolarization, alterations of ADP/ATP ratio and activation of AMPK pathway stimulating the autophagic process in BC cells. The inhibition of autophagy, by using the specific inhibitor bafilomycin A or Beclin 1 knock-down, enhanced the CPS-induced cell death, demonstrating that CPS-induced autophagy acts as a pro-survival process in BC cells. By using PCR arrays and FACS analysis, we found that the CPS-treated BC cells displayed typical mesenchymal features of the epithelial mesenchymal transition (EMT) as elongated shape and over-expression of vimentin, α5 and β1 integrin subunits, integrin-like kinase and the anti-apoptotic Bcl-2 proteins. Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels. By PTCH2 knock-down we found that the Hedgehog signaling pathway is involved in the CPS-induced autophagy and EMT phenotype.Finally, we also showed that the CPS-resistant EMT-positive BC cells displayed an increased drug-resistance to the cytotoxic effects of mitomycin C, gemcitabine and doxorubicine drugs commonly used in BC therapy.

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Section: Discussionmentioning

confidence: 99%

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

et al. 2016

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“…Angiogenesis is a complex process, which plays a role in various types of cancer [76–79]. TQ inhibits angiogenesis by suppressing the activation of one of the important motifs of angiogenesis.…”

Section: The Implications Of N Sativa In Cancer Therapymentioning

confidence: 99%

Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways

Rahmani

Alzohairy

Khan

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The cancer is probably the most dreaded disease in both men and women and also major health problem worldwide. Despite its high prevalence, the exact molecular mechanisms of the development and progression are not fully understood. The current chemotherapy/radiotherapy regime used to treat cancer shows adverse side effect and may alter gene functions. Natural products are generally safe, effective, and less expensive substitutes of anticancer chemotherapeutics. Based on previous studies of their potential therapeutic uses, Nigella sativa and its constituents may be proved as good therapeutic options in the prevention of cancer. Black seeds are used as staple food in the Middle Eastern Countries for thousands of years and also in the treatment of diseases. Earlier studies have shown that N. sativa and its constituent thymoquinone (TQ) have important roles in the prevention and treatment of cancer by modulating cell signaling pathways. In this review, we summarize the role of N. sativa and its constituents TQ in the prevention of cancer through the activation or inactivation of molecular cell signaling pathways.

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“…VEGF is a multifunctional cytokine that exerts a variety of effects on vascular endothelial cells that together promote the formation of new blood vessels, increases vascular endothelial permeability, stimulates the proliferation of endothelial cells and promote cancer cell progression (Dvorak, 2002;Mohammed et al, 2007;Niu et al, 2010;Akdeniz et al, 2013;Huang et al, 2013;Zhang et al, 2013). In particular, serum VEGF-A levels are elevated in patients with HNSCC compared to healthy controls (De Schutter et al, 2005;Hong et al, 2009;Liang et al, 2013).…”

Section: Serum Vascular Endothelial Growth Factor-a (Vegf-a) As a Biomentioning

confidence: 99%

Serum Vascular Endothelial Growth Factor-A (VEGF-A) as a Biomarker in Squamous Cell Carcinoma of Head and Neck Patients Undergoing Chemoradiotherapy

Srivastava

Gara²,

Rastogi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Cited by 22 publications

References 32 publications

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways

Serum Vascular Endothelial Growth Factor-A (VEGF-A) as a Biomarker in Squamous Cell Carcinoma of Head and Neck Patients Undergoing Chemoradiotherapy

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