Prognostic value of the Sinonasal Outcome Test 22 (SNOT-22) in chronic rhinosinusitis

Gallo, Stefania; Russo, Federico; Mozzanica, Francesco; Preti, Andrea; Bandi, Francesco; Costantino, Cecilia; Gera, Roberto; Ottaviani, F.; Castelnuovo, Paolo

doi:10.14639/0392-100x-n0364

Cited by 44 publications

(32 citation statements)

References 29 publications

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“…In the literature, similar to our study, mucociliary clearance function and sinonasal complaints were evaluated in pathologies that directly affect the nasal mucosa, such as acute rhinitis and chronic rhinosinusitis. More significant changes were found in these studies compared to those obtained in our study [ 29 , 30 ]. This suggests that increases in MCT, nasal blockage and postnasal discharge complaints detected in the N95 mask group and the increase in nasal blockage complaint seen in the surgical mask group were mild.…”

Section: Discussionsupporting

confidence: 47%

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

Cengiz

Can

2021

Eur Arch Otorhinolaryngol

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Purpose The aim of this study was to reveal the effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints. Methods Sixty participants were enrolled in this study, including 30 people in N95 mask group and 30 people in surgical mask group. Two interviews, three days apart, were performed with all participants. The participants were asked not to use any mask before the first interview while they were asked to use the determined mask just before the second interview for 8 h. In both interviews, the mucociliary clearance times (MCTs) were measured and participants were asked to score ten distinct sinonasal complaints using visual analog scale (VAS). Data obtained from first interview were named pre-mask data, data obtained from second interview were called after-mask data. In both groups, pre-mask MCTs and VAS scores were compared with after-mask MCTs and VAS scores. Results After-mask MCTs (mean = 13.03 ± 6.05 min) were significantly longer than pre-mask MCTs (mean = 10.19 ± 4.21 min) in N95 mask group ( p = 0.002). No significant difference was found between after-mask and pre-mask MCTs (mean = 12.05 ± 5.21 min, mean = 11.00 ± 5.44 min, respectively) in surgical mask group ( p = 0.234). When after-mask VAS scores were compared with pre-mask VAS scores, it was found that N95 mask use increased nasal blockage and postnasal discharge, surgical mask usage increased nasal blockage. Conclusion While the use of N95 mask leads to nasal blockage and postnasal discharge, surgical mask use results in nasal blockage. N95 masks cause impairment in mucociliary clearance function. But all these effects are mild. Surgical masks have not been found to have any effect on mucociliary clearance function.

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Section: Discussionsupporting

confidence: 47%

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

Cengiz

Can

2021

Eur Arch Otorhinolaryngol

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“…Sensitization for common inhalants was evaluated on the basis of recent pre-existing skin or blood tests as defined by the Global Atlas Test Panel for Europe 20 . Symptoms were collected through the Italian version of the SinoNasal Outcome Test 22 (SNOT 22) questionnaire 21 and analysed both as total (SNOT 22) and partial (SNOT 1-12) scores, and as individual symptoms 22,23 . Endoscopic findings of the entire cohort were scaled according to the Lund-Kennedy Score (LKS) 24 and the size of nasal polyps in the CRSwNP subgroup was calculated through the Nasal Polyp Score (NPS) 25 .…”

Section: Parole Chiave: Rinosinusite Cronica Polipi Nasali Asma Anmentioning

confidence: 99%

Effects of biological therapies on chronic rhinosinusitis in severe asthmatic patients

Bandi

Gallo

Preti

et al. 2020

Acta Otorhinolaryngol Ital

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Objective. The introduction of monoclonal antibody (mAb) therapies represents a promising treatment for refractory chronic rhinosinusitis (CRS). We assessed the effects of selected mAbs (omalizumab, mepolizumab, benralizumab) on CRS in severe asthmatic patients in a real-life setting. Methods. A prospective observational study on severe asthmatic patients, treated with 3 different mAb (omalizumab, mepolizumab, benralizumab), and comorbid CRS was conducted. All patients were followed for 52 weeks. The degree of nasal control, SinoNasal Outcome Test (SNOT) 22, Nasal Polyp Score (NPS), Lund Kennedy Score (LKS) were collected at baseline and at 52-week. Results. 40 patients (33 with nasal polyps) were studied. 33 patients (82.5%) had uncontrolled nasal disease at baseline, and 15 (37.5%) were uncontrolled after 52 weeks. Significant improvement was observed for SNOT 22 (P < 0.001), SNOT 1-12 (P < 0.001) and degree of nasal control (P < 0.001). Differences in NPS (P = 0.130) and LKS (P = 0.124) were not significant. Net change in the above-mentioned parameters among the three treatment groups was not significantly different. Conclusions. The study shows an improvement of nasal symptoms after 52 weeks of mAb treatment, which was not associated with significant improvement of endoscopic findings. Larger studies are needed to assess the real-life efficacy of mAbs in CRS.

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“…In the rapidly evolving world of clinical research in rhinology, the number of patients should be increased and the data should be re-evaluated and enriched with increasingly popular scores (e.g. SNOT 27 , ACT, UPSIT) and information that help in defining the endotype (e.g. FeNO, periostin and blood eosinophils, but also expression of inflammatory cytokines) 28 and to stratify the results and impact of surgery according to the endotype.…”

Section: Discussionmentioning

confidence: 99%

A prospective pilot study on the effects of endoscopic sinus surgery on upper and lower airway performance

Atzei

Melis

Luca

et al. 2021

Acta Otorhinolaryngol Ital

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SUMMARY Objective The relationship between chronic rhinosinusitis, asthma and allergic rhinitis is well known, but only recently has the scientific community started to evaluate these as different manifestations of a common pathogenic phenomenon, considering them as a unified airway disease. Methods Twenty-two patients with chronic rhinosinusitis treated with endoscopic sinus surgery (ESS) were included in the study. Sino-nasal assessment questionnaire (SNAQ) investigating subjective evaluation of sino-nasal state was administered to patients, while objective evaluations included nasal endoscopy, sinonasal CT, skin prick tests, nasal cytology, spirometry, bronchodilator responsiveness testing and sputum eosinophil count. All tests were performed before surgery. Two months after surgery, SNAQ questionnaire, nasal endoscopy, spirometry and bronchodilator responsiveness testing were repeated. Results All patients had significant improvement of subjective status: mean SNAQ score decreased in all from 99.31 to 16.04. Mean Forced Expiratory Volume in the 1 st second (FEV 1 ) significantly improved after surgery from 3.23 to 3.45 L/s. Conclusions ESS achieved a beneficial effect on upper and lower airway status in patients with chronic rhinosinusitis with or without lower airway diseases.

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Prognostic value of the Sinonasal Outcome Test 22 (SNOT-22) in chronic rhinosinusitis

Cited by 44 publications

References 29 publications

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

Effects of biological therapies on chronic rhinosinusitis in severe asthmatic patients

A prospective pilot study on the effects of endoscopic sinus surgery on upper and lower airway performance

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