Prognostic value of the presence and development of atrial fibrillation in patients with advanced chronic heart failure

Crijns, Hjgm; Tjeerdsma, Geert; Kam, P.J. de; Boomsma, Frans; Gelder, Isabelle C. Van; Berg, Maarten P. van den; Veldhuisen, Dirk J. van

doi:10.1053/euhj.1999.2107

Cited by 223 publications

(164 citation statements)

References 30 publications

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“…In that study, incident atrial fibrillation was associated with a significant increase in the risk of all-cause death; however, prevalent atrial fibrillation was not associated with any increased risk of death in this cohort of ambulatory older adults with heart failure. Crijns et al studied 409 patients with chronic heart failure of whom 325 were in sinus rhythm and 84 had prevalent atrial fibrillation [4]. During the study follow-up, of the 325 patients with sinus rhythm, 30 were newly diagnosed with atrial fibrillation.…”

Section: Resultsmentioning

confidence: 99%

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Incident atrial fibrillation and mortality in older adults with heart failure

Ahmed

Perry

2005

European J of Heart Fail

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We studied 944 hospitalized heart failure patients 65 years and older to examine the impact of incident atrial fibrillation on mortality. Patients were categorized into four groups based on past medical history and admission electrocardiogram: (1) no (neither past nor current), (2) incident (newly diagnosed), (3) past and (4) chronic (past and current) atrial fibrillation. The primary outcome was 4-year all-cause mortality. Bivariate and multivariable Cox proportion hazards analyses were used to determine risk of all-cause mortality. In the multivariable model, we adjusted for various demographic and clinical covariates. Compared with patients who never had atrial fibrillation, those with incident atrial fibrillation had a 57% higher risk of death (unadjusted hazard ratio, 1.57; 95% confidence interval, 1.22-2.03). After adjustment for other covariates the association remained unchanged (adjusted hazard ratio, 1.41; 95% confidence interval, 1.08-1.83). Past or chronic atrial fibrillation was not associated with increased risk of death.

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Section: Resultsmentioning

confidence: 99%

“…The prevalence of atrial fibrillation in older adults with heart failure is high and is associated with poor outcomes [1][2][3][4]. The impact of incident and prevalent atrial fibrillation on mortality among community dwelling chronic heart failure patients has been reported [2].…”

Section: Introductionmentioning

confidence: 99%

Incident atrial fibrillation and mortality in older adults with heart failure

Ahmed

Perry

2005

European J of Heart Fail

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“…[3][4][5] To what extent the presence and development of this arrhythmia retains a prognostic role in patients with heart failure remains debatable. [6][7][8][9][10][11][12][13] To date, few studies have evaluated the predictive value of new onset AF in heart failure populations; the results of which have been contradictory. 7,[9][10][11][14][15][16][17] Analyses specifically exploring the role of AF in the subset of patients affected by idiopathic dilated cardiomyopathy (IDCM) are even more scarce and report highly conflicting data.…”

Section: Linkedmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13] To date, few studies have evaluated the predictive value of new onset AF in heart failure populations; the results of which have been contradictory. 7,[9][10][11][14][15][16][17] Analyses specifically exploring the role of AF in the subset of patients affected by idiopathic dilated cardiomyopathy (IDCM) are even more scarce and report highly conflicting data. [18][19][20] Most of these studies lack information about the natural history of AF in patients who are optimally managed with angiotensin-converting enzyme (ACE) inhibitor and beta-blocker therapy.…”

Section: Linkedmentioning

confidence: 99%

Impact of Atrial Fibrillation on Outcome of Patients with Idiopathic Dilated Cardiomyopathy: Data from the Heart Muscle Disease Registry of Trieste

Aleksova¹,

Merlo²,

Zecchin³

et al. 2010

Clinical Medicine & Research

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Objective: There is a paucity and inconsistency of data regarding the natural history of patients affected by idiopathic dilated cardiomyopathy (IDCM) and atrial fibrillation (AF). We examined the prognostic implications of AF in a subset of patients with IDCM. Methods:We analyzed the data of 539 patients with IDCM enrolled in the Heart Muscle Disease Registry of Trieste.Results: At baseline, 52 (9.6%) of 539 patients had AF. There was no difference in survival of patients with either AF or sinus rhythm at enrollment (P=.28). During long-term follow-up (90±58 months), AF was detected on ECG/ECG-Holter monitoring in 28 (5.7%) of 487 patients in sinus rhythm at baseline. Predictors of new onset of AF at multivariate analysis were a more dilated left atrium (OR 1.35, 95% CI 1.06-1.72; P=.01) and a lower left ventricle ejection fraction (for 10% decrease, OR 2.41, 95% CI 1.24-4.69, P=.016). Patients developing AF had higher mortality/heart transplantation rate compared to patients who maintained sinus rhythm during follow-up (P<.001). At multivariate analysis, new onset AF (HR 3.67, 95% CI 2.07-6.5; P<.001) in the first three years after diagnosis, but not baseline AF, was found to be independently associated with a worse outcome. Conclusions:Atrial fibrillation is relatively frequent in patients with IDCM. The early development of AF during follow-up, but not its presence at baseline, is associated with poor survival.

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“…в возрасте старше 80 лет [13]. У боль-ных СН частота развития ФП в течение 3 лет достига-ла 10% [14]. Ингибирование ангиотензина может со-провождаться снижением риска развития ФП у боль-ных СН [15] и АГ [16].…”

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American College of Cardiology, American Heart Association and European Society of Cardiology (2006) Guidelines for the Management of Patients With Atrial Fibrillation

Fuster¹,

Ryden²,

Cannom³

et al. 2007

Racionalʹnaâ farmakoterapiâ v kardiologii

120

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Отчет рабочей группы Американской коллегии кардиологов и Американской ассоциации сердца по практическим рекомендациям и комитета Европейского общества кардиологов по практическим рекомендациям Рекомендации разработаны в сотрудничестве с Европейской ассоциацией сердечного ритма и Обществом сердечного ритма Авторы (члены рабочей группы): V.

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Prognostic value of the presence and development of atrial fibrillation in patients with advanced chronic heart failure

Cited by 223 publications

References 30 publications

Incident atrial fibrillation and mortality in older adults with heart failure

Incident atrial fibrillation and mortality in older adults with heart failure

Impact of Atrial Fibrillation on Outcome of Patients with Idiopathic Dilated Cardiomyopathy: Data from the Heart Muscle Disease Registry of Trieste

American College of Cardiology, American Heart Association and European Society of Cardiology (2006) Guidelines for the Management of Patients With Atrial Fibrillation

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