Prognostic value of the platelet to lymphocyte ratio change in liver cancer

Peng, Wei; Li, Chuan; Zhu, Wen-Jiang; Wen, Tianfu; Yan, Lvnan; Li, Bo; Wang, Wentao; Yang, Jiayin

doi:10.1016/j.jss.2014.12.021

Cited by 36 publications

(28 citation statements)

References 34 publications

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“…But all the included patients in Peng et al . study were with HBV-related small HCC, which might have caused the difference between its outcome and the result of our study [44]. Additionally, our study indicated that high PLR was an unfavorable factor for patients receiving TACE with HCC.…”

Section: Discussionmentioning

confidence: 57%

“…in Singapore ( p = 0.341) [21], and a similar result was detected in Peng et al . study in China ( p = 0.856) [44], however, they were both excluded from the meta-analysis because they only reported the relevant p values without HR. Therefore, more prospective cohort studies should be carried out to explore the prognostic role of PLR in HCC in Asian.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Zhao

Zhu

et al. 2017

Oncotarget

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Background and AimsSeveral studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC.ResultsA total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5. The results indicated that high PLR was significantly associated with a worse OS when compared to the low PLR (HR = 1.60, 95% CI = 1.23−2.08, p = 0.0005; I2 = 88%, p < 0.00001). Similar results were detected in the subgroup analysis of the analysis model, cut-off value, ethnicity, sample size and therapy. However, no obvious correlation between the PLR and DFS/RFS in patients with HCC was observed (HR = 1.21, 95% CI = 0.87−1.67, p = 0.26; I2 = 61%, p = 0.07).Materials and MethodsA complete literature search in the PubMed, Cochrane Library and Embase database was performed. Retrospective and prospective studies focusing on the role of PLR on the prognosis in HCC were all deemed as “suitable” for our scope. The endpoints determined were: the overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and the progress free survival (PFS).ConclusionsThe study revealed that high PLR is an unfavorable predictor of OS in patients with HCC, and high PLR is a promising prognostic biomarker for HCC, especially for patients in Asia.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Zhao

Zhu

et al. 2017

Oncotarget

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“…The NLR which is an indicator of immune response and systematic inflammation, has a prognostic effect on many diseases including coronary artery disease 5,6 and cancer. 7,8 In the literature, few studies showed that NLR was meaningful for the diagnosis of diabetes and for the prediction of development of diabetic complications. 9,10 Whether or not NLR can predict the prognosis in diabetic foot infection is unclear.…”

Section: Introductionmentioning

confidence: 99%

Can Ratio of Neutrophil-Tolymphocyte Count and Erythrocyte Sedimentation Rate in Diabetic Foot Infection Predict Osteomyelitis and/or Amputation?

et al. 2017

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The aim of this study was to search for any relations between the neutrophil-to-lymphocyte ratio (NLR) and the development of osteomyelitis and the need for amputation in patients with diabetic foot infection (DFI). All data included DFI patients who were hospitalized in our Infectious Diseases Clinic between 2012 and 2015 and who were classified according to International Classification Disease Code System. 75 patients were analyzed in the study. The DFI patients were stratified into 3 groups of whom had amputation procedure, whom had only debridement/drainage procedure and whom had any surgery procedure. Sidac post hoc analysis was used to perform the effects of NLR, C-reactive protein, erythrocyte sedimentation rate and glycosylated hemoglobin on the surgery procedure status. The DFI patients were also stratified into two another separate group for another analysis to search for the effect of NLR values on the development of osteomyelitis. The mean value of NLR in the amputated patients’ group (15.7±10.3 was significantly higher than those with debridement procedure (9.9±5.6) and those without any surgery (6.0±2.8) (P=0.001). NLR values were also found significantly higher in patients with osteomyelitis in the second analysis (P=0.004). In this study, the NLR was found to have a predictive value on the development of osteomyelitis and on the progression to amputation in patients with DFI.

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“…Established prognostic factors include liver function reserve, tumor size and number, vascular invasion, and the systemic inflammation response. [8–12] …”

Section: Introductionmentioning

confidence: 99%

Postoperative aspartate aminotransferase to platelet ratio index change predicts prognosis for hepatocellular carcinoma

Peng

Li²,

Wen³

et al. 2016

Medicine

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An elevated preoperative aspartate aminotransferase (AST) to platelet ratio index (APRI) is reported to be a prognostic factor for patients with hepatocellular carcinoma (HCC) after treatment. However, delta APRI (ΔAPRI), which represents the change from preoperative to postoperative APRI, has received little attention. The present study was designed to evaluate the prognostic value of ΔAPRI in patients with small HCC after liver resection.A retrospective cohort study analyzing 244 patients with small HCC who had undergone liver resection was conducted. Medical data were retrieved from our prospectively maintained database. Patients were divided into 2 groups according to ΔAPRI as follows: group A (ΔAPRI ≥0.02) and group B (ΔAPRI <0.02). The association of demographic and clinical data, overall survival (OS), and recurrence-free survival (RFS) were statistically compared in the 2 groups, and a multivariate analysis was used to identify prognostic factors.The 1, 3, and 5-year OS of patients in group A were 94.2%, 79.5%, and 62.3%, respectively, and 95.1%, 87.9%, and 84.6%, respectively, for patients in group B (P = 0.001). The corresponding 1, 3, and 5-year RFS was 69.0%, 44.7 %, and 28.1%, and 77.4%, 57.0%, and 54.2% for patients in the 2 groups, respectively (P = 0.009). The results of a multivariate analysis indicated that ΔAPRI was an independent prognostic factor for both OS (P = 0.001, hazard ratio 3.115, 95% confidence interval 1.642–5.912) and RFS (P = 0.006, hazard ratio 1.689, 95% confidence interval 1.163–2.452).A positive ΔAPRI after liver resection predicts decreased OS and RFS in patients with small HCC.

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Prognostic value of the platelet to lymphocyte ratio change in liver cancer

Cited by 36 publications

References 34 publications

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Can Ratio of Neutrophil-Tolymphocyte Count and Erythrocyte Sedimentation Rate in Diabetic Foot Infection Predict Osteomyelitis and/or Amputation?

Postoperative aspartate aminotransferase to platelet ratio index change predicts prognosis for hepatocellular carcinoma

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