Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review

Starzyńska, Anna; Sejda, Aleksandra; Adamska, Paulina; Marvaso, Giulia; Sakowicz-Burkiewicz, Monika; Adamski, Łukasz Jan; Jereczek‐Fossa, Barbara Alicja

doi:10.5114/aoms.2020.100780

Cited by 18 publications

(17 citation statements)

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“…In the study of liver cancer, it was found that the full-length apoptosis-inducing factor mitochondrial-associated 1 ( AIFM1 ) (∼67 kDa) was cleaved at its N-terminus to produce truncated AIFM1 (∼57 kDa), which was not dependent on caspase Enzymes induce apoptosis, overexpression of full-length AIFM1 can induce caspase-dependent apoptosis and inhibit cell growth of liver cancer cells, our data reveal the potential role of rAd- AIFM1 in HCC gene therapy ( 31 ). Studies have shown that PIK3CA is a prognostic factor for oral cancer, and studies have also shown that PIK3CA is involved in the metabolic mechanism of breast cancer ( 32 , 33 ). Inhibition of PIK3CA can cause tumor regression in nude mice ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

A Signature of Three Apoptosis-Related Genes Predicts Overall Survival in Breast Cancer

et al. 2022

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BackgroundThe commonest malignancy in women is known as breast cancer (BC). Numerous studies demonstrated that apoptosis appears to be critical to the management and clinical outcome of BC patients. The purpose of this study is to explore the potential connection between apoptosis and BC and establish the apoptosis-associated gene signature in BC.MethodsThe data of BC patient transcripts and related clinical information comes from the Cancer Genome Atlas Database (TCGA), and the genes related to apoptosis come from the Molecular Characterization Database (MSigDB). We identified the abnormally expressed apoptosis-related genes in BC samples. The optimal apoptosis-related genes screened by Cox regression analysis were designed to construct a prognostic model for predicting BC patients. Using the Nom Chart to Predict 1-Year, 3-Year, and 5-Year overall survival for BC patients. The gene signature-related functional pathways were explored by gene set enrichment analysis (GSEA).ResultsThree genes [alpha subunit of the interleukin 3 receptor (IL3RA), apoptosis-inducing factor mitochondrial-associated 1 (AIFM1), and phosphatidylinositol-3 kinase catalytic alpha (PIK3CA)] correlated with apoptosis were shown to be strongly linked to the overall survival of BC. Survival analysis shows that the risk score is directly proportional to the poor prognosis of BC patients. Risk assessment based on three genetic characteristics (age, pathological stage N, and pathological stage M) can independently predict the prognosis of patients with BC. The Nom chart is most suitable for assessing the long-term survival rate of BC patients. The results of GSEA demonstrated that numerous cell cycle-related pathways were abundant in the high-risk group.ConclusionWe constructed an apoptosis-associated gene signature in BC, which had a potential clinical application prospect for BC patients.

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Section: Discussionmentioning

confidence: 99%

A Signature of Three Apoptosis-Related Genes Predicts Overall Survival in Breast Cancer

et al. 2022

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“…Oral carcinogenesis involves the accumulation of various genetic aberrations, including DNA mutation, epigenetic changes (DNA methylation) and chromosomal aberrations. More recently, NOTCH1, PIK3CA, AKT, PTEN and TRIM21 genomic changes have been identified as actionable genetic changes in oral cancers [5][6][7]. While chemotherapeutic regimens (cisplatin with or without fluorouracil and docetaxel) are most commonly used for the treatment of oral squamous cell carcinoma (OSCC), patients with prolonged chemotherapy develop a relapse due to chemoresistance [8].…”

Section: Introductionmentioning

confidence: 99%

Development of a murine model of oral carcinogenesis: an accelerated tool for biomarker and anti-tumour drug discovery

Syed¹,

Qureshi²,

Khan³

et al. 2022

ecancer

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Oral squamous cell carcinoma (OSCC) is the most common cancer in Pakistani men and the second most common cancer in women. The objective of our study was to devise a novel accelerated murine model of oral carcinogenesis that can be exploited as a tool to investigate the cancer circuitry involved in OSCC and to identify molecules of diagnostic, therapeutic and prognostic significance. A total of 40 healthy male, 6–8 weeks old, 22 ± 2 gram, Naval Medical Research Institute (NMRI) outbred strain mice were recruited in the experiment. NMRI mice are commonly used for animal experiments in various fields of biology and for drug toxicity. Of these, 25 mice underwent the oral carcinogenesis regimen via topical application of 0.5% 9,10-dimethyl-1,2-benzanthracene (DMBA) on the lower left lip for a maximum of 20 weeks and 15 mice were used as controls (without the carcinogenic regimen). Exophytic tissue masses were harvested, fixed in 10% formalin and stained with haematoxylin and eosin (H&E) for microscopic diagnosis. Additionally, the expression levels of CK 5/6, p53 and Ki-67 were investigated using immunohistochemistry. Of the 25 mice which underwent the carcinogenic regimen, 21 developed moderately differentiated squamous cell carcinoma and 1 showed dysplastic features with foci of invasion. Three mice were found dead with lesion(s). CK 5/6 showed strong positivity (100%) and p53 and Ki-67 showed patchy (<30%) strong positivity in OSCC, suggesting the similarity of our model to human OSCC. We present an accelerated, close-to-human carcinogenesis, model of oral carcinogenesis using DMBA in NMRI mice that can be exploited to study the pathogenesis of oral squamous cell carcinoma and subsequently devise immunotherapy or targeted therapy.

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“…Carcinomas of the tongue and floor of the oral cavity are frequently locally advanced at the time of the first presentation and show a worse prognosis than other oral cancers. Nevertheless, other factors related to tumor biology and its immune microenvironment may also influence the prognosis or be the targets for personalized therapy [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

High PD-L1 Expression on Tumor Cells Indicates Worse Overall Survival in Advanced Oral Squamous Cell Carcinomas of the Tongue and the Floor of the Mouth but Not in Other Oral Compartments

et al. 2021

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The markers of the tumor microenvironment (TME) are promising prognostic and predictive factors in oral squamous cell carcinoma (OSCC). The current study aims to analyze the immunohistochemical expression of programmed cell death-ligand 1 (PD-L1) and interleukin-33 (IL-33) in a cohort of 95 chemonaïve OSCCs. PD-L1 and IL-33 were assessed separately in tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs). High PD-L1 expression in TILs was associated with better overall survival (OS) in univariate analysis. Tumors localized in the floor of the oral cavity and tongue tended to have a lower percentage of PD-L1-positive TCs when compared to other locations. PD-L1 expression on TCs had no prognostic significance when the whole cohort was analyzed. However, along with the T descriptor (TNM 8th), it was included in the multivariable model predicting death in carcinomas of the floor of the oral cavity and tongue (HR = 2.51, 95% CI = 1.97–5.28). In other locations, only nodal status was identified as an independent prognostic factor in multivariate analysis (HR = 0.24, 95% CI = 0.08–0.70). Expression of IL-33 had no impact on survival, but it was differently expressed in various locations. In conclusion, the prognostic significance of PD-L1 in oral cancer depends on the tumor site and type of cell expressing immune checkpoint receptor (TCs vs. TILs).

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Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review

Cited by 18 publications

References 93 publications

A Signature of Three Apoptosis-Related Genes Predicts Overall Survival in Breast Cancer

A Signature of Three Apoptosis-Related Genes Predicts Overall Survival in Breast Cancer

Development of a murine model of oral carcinogenesis: an accelerated tool for biomarker and anti-tumour drug discovery

High PD-L1 Expression on Tumor Cells Indicates Worse Overall Survival in Advanced Oral Squamous Cell Carcinomas of the Tongue and the Floor of the Mouth but Not in Other Oral Compartments

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